New flavonoids and other constituents from Ouratea hexasperma (Ochnaceae)

Abstract

O estudo fitoquímico do extrato metanólico de galhos de Ouratea hexasperma (Ochnaceae) forneceu dois novos flavonóides,

Flavonoids and their glycosides, including anthocyanins

“…502 Three 7-O-glycosides of prenylated dihydroflavonols (737-739) have been reported from species in the Berberidaceae and Ochnaceae. [273][274][275] In each case, O-glycosides of prenylated flavonols were also found (see 361-365, 371, 372). MeOH extracts of the aerial parts of Cephalotaxus koreana (a synonym of Cephalotaxus harringtonii var.…”

“…In other work, sinocrassosides A 1 (194), A 2 (195) and B 2 (296) showed a significant hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes compared to the control, silybin (the whole plant of S. indica is used to treat hepatitis in traditional Chinese medicine). 206 When tested in the same bioassay, sachalosides III (178) and IV (274) showed hepatoprotective effects equivalent to that of silybin. The latter compounds, which are flavonol 3,7-di-O-glycosides, were obtained from MeOH extracts of the roots of another Crassulaceae species used in traditional Chinese medicine, Rhodiola sachalinensis Boriss.…”

“…A broad spectrum of other bioassays carried out in conjunction with the isolation of new flavonol O-glycosides (Table 2) includes assessment of allergy-preventive activity (286), aminopeptidase N inhibition (194, 195, 209, 220-223, 236, 273, 295, 296, 312, 317, 318, 348, 349), antifungal activity (180,245,249,250), anti-HIV-1 activity (371,372), anti-inflammatory activity (275), anti-methicillin-resistant Staphylococcus aureus (MRSA) activity (196)(197)(198), cyclooxygenase inhibition (283, 375), cytotoxicity (175,253,254,322,345), estrogenic activity (225,226), a-glucosidase inhibition (170,200,218), hepatoprotective activity (178,194,195,274,296,315), and myeloperoxidase inhibition (192). Bioassay-guided fractionation of MeOH extracts of the petals of the ornamental plant Hibiscus mutabilis 'Versicolor' for allergy-preventive constituents yielded 5 flavonols, of which mutabiloside (286) and the known analogue quercetin 3-O-b-xylopyranosyl-(1/2)-b-galactopyranoside had activity comparable to a number of clinically-used products, including disodium cromoglycate.…”

“…Tiegh). 274 Matsudone A (375) is a pyranoflavonol glycoside with cyclooxygenase-2 inhibitory activity isolated from leaf extracts of a species of Salicaceae, Salix matsudana Koidz. (a synonym of Salix babylonica L.).…”

Phytomedicine and Allied Compounds in Both Human and Animal Healthcare

“…This is indicated by the growing popularity of Traditional Chinese Medicine (TCM) and Ayuverdic medicine of India Jiang et al [15]; Dubey et al [16]. In Africa, the use of traditional medicine is very high as indicated by the fact that between 70 and 80% of the population depend on herbal preparations for primary healthcare with little or no scientific information on efficacy and side effects Kokwaro [17][18][19][20][21][22][23][24][25]. Furthermore, even the people of the developed world are also dependent directly or indirectly on plants for their health care.…”