Others flavonoids from Ouratea hexasperma (Ochnaceae)

Biodiversidade flavonoídica e aspectos farmacológicos em espécies dos gêneros Ouratea e Luxemburgia (Ochnaceae)

“…Do gênero Ouratea foram isolados biflavonóides dos grupos amentoflavona (11,18), agatisflavona (35), bigenkanina (8), lanaraflavona (15) e seus derivados, além de outros dímeros como lofironas (32), calodeninas (28, 31) e flavumonas (29,30). A junção de isoflavanonas (C-2→C-2'') deu origem às hexaspermonas A, B e C (4; 5; 6), respectivamente.…”

“…De acordo com os átomos de carbonos envolvidos na ligação entre as unidades, os dímeros são classificados em grupos de biflavonóides (Figura 1) 9-11 , além dos dímeros de chalconas: C-3→O-C-4''' (luxenchalconas) 12 e C-3'→C3'' (brackeninas) 13 e dos dímeros de isoflavonas C-2→C-2'' (hexaspermonas) 14 , sem destacar os dímeros com duas ligações entre as unidades. Certos grupos hidroxila podem apresentar-se metilados, originando os respectivos éteres metílicos que, às vezes, recebem nomes especiais [15][16][17][18] .…”

“…Nos casos dos gêneros Ouratea e Luxemburgia, além de alguns monômeros, tem-se detectado com freqüência a presença de bi-ou bisflavonóides, destacando-se as hexaspermonas (4-6), amentoflavonas (11,18), agatisflavonas (12) e robustaflavona (24), lanaraflavonas (15)(16)(17)34) em Ouratea, Figura 2. Em Luxemburgia foram detectados os biflavonóides derivados de chalconas, luxenchalcona (25, C-3'→O-C-4''') e ochnaflavona (20, também C-3'→O-C-4'''), Figura 2, que podem ter como precursor a luxenchalcona.…”

Anti-inflammatory activities of flavonoids from Luxemburgia octandra flowers

“…Ochnaceae is a large tropical family including 40 genera and 600 species with the greatest concentration in tropical South America [3]. In the course of our phytochemical and pharmacological investigations of Brazilian plants, we have studied species of both Ouratea and Luxemburgia genera, in which the presence of biflavonoids was observed [4][5][6][7], along with their antitumor activities [8][9][10].In the present study we investigated the anti-inflammatory activity of the flavonoids 2cc,3cc-dihydro-ochnaflavone (1), 7-O-methylorientin (2), orientin (3), orientin 2cc-O-glucoside (4), and catechin (5) using the mouse model of ear edema.The structures of the flavonoids 2cc,3cc-dihydro-ochnaflavone (1), 7-O-methylorientin (2), orientin (3), orientin 2cc-O-glucoside (4), and catechin (5) were identified by EI-MS, 1 H NMR, 13 C NMR, and comparison of those with literature data [11,12].Flavonoids 1-5 were tested in vivo for their ability to reduce the inflammatory response in the TPA-induced ear edema in mice (1.0 mg/ear). Compounds 2 and 3 showed activity in the ear topical test, inducing an edema inhibition over 50%, which was comparable to that of indomethacin at a dose of 0.5 mg/ear (Table 1).…”

“…Ochnaceae is a large tropical family including 40 genera and 600 species with the greatest concentration in tropical South America [3]. In the course of our phytochemical and pharmacological investigations of Brazilian plants, we have studied species of both Ouratea and Luxemburgia genera, in which the presence of biflavonoids was observed [4][5][6][7], along with their antitumor activities [8][9][10].…”