Biodiversidade flavonoídica e aspectos farmacológicos em espécies dos gêneros Ouratea e Luxemburgia (Ochnaceae)

Suzart, Luciano Ramos; Daniel, Juliana Feijó de Souza; Carvalho, Mário Geraldo de; Kaplan, Maria Auxiliadora Coelho

doi:10.1590/s0100-40422007000400038

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…Some biflavonoids, as well as extracts of the Ouratea species showed important biological activities, as was previously published (Suzart et al, 2007).…”

supporting

confidence: 73%

“…Ouratea and other genera of Ochnaceae are a rich source of flavonoids and biflavonoids and according to Suzart et al (2007), the biflavonoids can be used as chemotaxonomic markers of the genus Ouratea as well as of Luxemburgia from the same botanic family. Lignans, triterpenes, diterpenes, steroids, monosaccharide, depsides, was collected in Marajó Island in the North of Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Biflavones and triterpenoids isolated from Ouratea castaneifolia (DC.) Engl., Ochnaceae

Nascimento¹,

Guilhon²,

Arruda³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Biflavonas e triterpenóides isolados de Ouratea castaneifolia (DC.) Engl., Ochnaceae". O presente trabalho trata da investigação química das folhas e caule da espécie Ouratea castaneifolia (DC.) Engl., sobre a qual não há registros de estudos químicos ou farmacológicos anteriores. O estudo fitoquímico clássico dos extratos orgânicos do caule e das folhas de O. castaneifolia foi aliado à técnica da cromatografia líquida de alta eficiência (CLAE) e resultou na identificação de dezessete metabólitos: sete triperpenos (friedelina, 3β-friedelinol, α-amirina, β-amirina, lupeol, taraxerol e germanicol), quatro esteróides (sitosterol, estigmasterol e os glucosídeos sitosteril 3-O-β-D-glicopiranosídeo e estigmasteril 3-O-β-D-glicopiranosídeo), uma isoflavona (5,7,4´-trimetoxiisoflavona), uma flavona (5,4´-diidroxi-7,3´,5´-trimetoxiflavona), quatro biflavonas (amentoflavona, 7,7"-O-dimetil-amentoflavona, heveaflavona e tetrametilamentoflavona). A identificação das substâncias foi feita com base na análise de espectros de RMN de 1 H, 13 C e técnicas bidimensionais. As classes dos metabólitos identificados estão de acordo com aquelas citadas em estudos químicos do gênero Ouratea.Unitermos: Ouratea castaneifolia, Ochnaceae, biflavonas, flavonóide, terpenóide.ABSTRACT: This paper presents the chemical investigation of the leaves and stems of Ouratea castaneifolia (DC.) Engl.. There are no chemical or pharmacological studies with this species. Classic phytochemical investigation of the organic extracts together with high pressure liquid chromatography (HPLC) procedures lead to the identification of seventeen metabolites: seven triterpenes (friedelin, 3β-friedelinol, α-amyrin, β-amyrin, lupeol, germanicol and taraxerol), four steroids (sitosterol, stigmasterol and the glycosides sitosteryl 3-O-β-D-glucopyranoside and stigmasteryl 3-O-β-D-glucopyranoside), one isoflavone (5,7,4'-trimethoxyisoflavone), one flavone (5,4'-dihydroxy-7,3',5'-trimethoxyflavone) and four biflavones (amenthoflavone, 7,7"-O-dimethylamenthoflavone, heveaflavone and tetramethylamenthoflavone). The structures of the compounds were established by the analysis of 1 H, 13 C NMR spectra including bidimensional techniques. The classes of the identified metabolites are in agreement with previous studies of the Ouratea genus.Keywords: Ouratea castaneifolia, Ochnaceae, biflavones, flavonoid, terpenoid.triglycerides and chloroisoflavones were also reported from this genus (Velandia et al., 1998a and 1998b;Carvalho et al., 2000;Manga et al., 2001;Mbing et al., 2003a and2003b; Felício et al., 2004;Estevam et al., 2005). Some biflavonoids, as well as extracts of the Ouratea species showed important biological activities, as was previously published (Suzart et al., 2007).Ouratea castaneifolia (DC.) Engl. Ochnaceae Biflavones and triterpenoids isolated from Ouratea castaneifolia (DC.) Engl., Ochnaceae

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“…Some biflavonoids, as well as extracts of the Ouratea species showed important biological activities, as was previously published (Suzart et al, 2007).…”

supporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Biflavones and triterpenoids isolated from Ouratea castaneifolia (DC.) Engl., Ochnaceae

Nascimento¹,

Guilhon²,

Arruda³

et al. 2009

Rev. bras. farmacogn.

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“…butter might be composed of saturated and unsaturated fats such as, essential fatty acids (e.g., oleic, palmitic and linoleic acids). These fatty acids can act as a potential emollient improving barrier function of the stratum corneum and consequently preventing transepidermal water loss (TEWL) favoring cutaneous hydration [2,3]. In addition, vegetable oils and fats such as Ouratea sp.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ouratea sp. butter in the crystallinity of solid lipids used in nanostructured lipid carriers (NLCs)

Galvão

Trindade

Santos

et al. 2015

J Therm Anal Calorim

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The aim of this work was to evaluate the effect of Ouratea sp. butter (OB) on crystallinity of solid lipids used in nanostructured lipid carriers systems. Firstly, the composition of fatty acids in OB was evaluated by transesterification reaction for gas chromatography fatty acid methyl ester analysis. The solid lipids such as stearic acid (SA), beeswax (BW) and carnauba wax (CW) were submitted to recrystallization process (heating-cooling). Moreover, binary mixtures between solid lipids and OB were prepared in ratio 1:1 (w/w) by heating of the components above the melting point followed by cooling at room temperature. Thus, the samples were characterized by differential scanning calorimetry (DSC), thermogravimetry (TG), X ray diffraction (XRD) and hot-stage polarized optical microscopy (HSPOM). DSC curves showed a shift of the melting point to lower temperatures in the lipid mixtures with OB. TG data suggested a thermal stability reduction in the lipid mixtures containing SA and CW and an increase thermal stability in the mixture containing BW. XRD data confirmed DSC results, showing a reduction in intensity of main diffraction peaks of the lipid mixtures and a presence of the amorphous portion in angle 2h: 22°. Finally, HSPOM demonstrated that the microstructures of solid lipids decreased in size and thickness in the mixtures containing OB at room temperature and slightly before the melting point, confirming previous characterizations. These results suggest that lipid mixtures with OB present a lower crystallinity, and it is expected that amorphous portion facilitates drug incorporation, for example.

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“…Têm como função mais importante a ação como antifúngico ou alimento dissuasivo para insetos e proteção contra os raios UV. São conhecidos também por sua atividade como estimulantes cardíacos e antiinflamatória (SIMÕES et al, 2004, SUZART et al, 2007 procianidinas, e os açúcares (SIMÕES et al, 2004).…”

Section: Flavonoidesunclassified

Pólen apícola desidratado: composição físico-química, qualidade microbiologica, compostos fenólicos e flavonoides, capacidade antioxidante e origem botânica

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Biodiversidade flavonoídica e aspectos farmacológicos em espécies dos gêneros Ouratea e Luxemburgia (Ochnaceae)

Cited by 21 publications

References 24 publications

Biflavones and triterpenoids isolated from Ouratea castaneifolia (DC.) Engl., Ochnaceae

Biflavones and triterpenoids isolated from Ouratea castaneifolia (DC.) Engl., Ochnaceae

Effect of Ouratea sp. butter in the crystallinity of solid lipids used in nanostructured lipid carriers (NLCs)

Pólen apícola desidratado: composição físico-química, qualidade microbiologica, compostos fenólicos e flavonoides, capacidade antioxidante e origem botânica

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