Model studies related to vanadium biochemistry: recent advances and perspectives

Abstract

Nos ultimos anos, vêm se acumulando as evidências sobre a necessidade de vanádio dos organismos mais evoluídos. Estudos de compostos modelos constituem-se numa importante ferramenta para o entendimento dos diferentes aspectos da bioquímica deste bioelemento. Neste artigo, apresentamos os resultados dos nossos estudos, assim como os de outros grupos de pesquisa, sobre compostos modelos relacionados a vários aspectos do metabolismo e detoxificação do vanádio e a haloperoxidasas dependentes do vanádio. São também apresentadas informações sobre as interações do cátion oxovanádio(IV), relevante do ponto de vista biológico, com bioligantes importantes, tais como nucleotideos, carboidratos, fosfatos e outros sistemas correlatos.Increasing evidence on the need of the higher forms of life for vanadium has accumulated during recent years. Model studies have become a very important tool to attain a better understanding of different aspects of the biochemistry of this bioelement. In this account we present the results of our own studies, as well as those of other research groups, on models related to different aspects of its metabolism and detoxification and to vanadium dependent haloperoxidases. Additional information about the interaction of the biologically relevant oxovanadium(IV) cation with important bioligands, such as nucleotides, carbohydrates, phosphates and related systems are also presented.

Vanadium Detoxification: Chemical and Biochemical Aspects

“…In some recent studies, the low-molecular-weight vanadium species present in urine was identified as a vanadium/ascorbate complex [59] [60]. But on the basis of the above mentioned results, it is most likely that the ligand may be any of the oxidation products of ascorbic acid (1), perhaps 2,3-dioxogulonic acid (5).…”

“…-Although information about the metabolism of physiological amounts of vanadium in the higher forms of life remains scarce, an increasing amount of data has been accumulated during recent years, mainly from animal studies. Therefore, general aspects related to the absorption, transport, biological transformations, toxicity, and excretion of vanadium become understandable [5] [24] [26] [27].…”

“…During the last years, we performed a series of model studies related to different aspects of this metabolic pattern in order to clarify some of its most important aspects [5] [27].…”

Bis(oxalato)dioxovanadate(V) and Bis(oxalato)oxoperoxo-vanadate(V) Complexes: Spectroscopic Characterization and Biological Activity

“…Although information about the metabolism of physiological amounts of vanadium in the higher forms of life, including man, remains scarce, some general aspects related to the absorption, transport, biological transformations, toxicity, excretion, and accumulation of vanadium are relatively well known [1,14,15]. In this context, the fact that bone seems to be the major sink for retained vanadium has been unambiguously demonstrated by numerous studies [14][15][16].…”

Synthesis and biological evaluation of cyclopenten-1-one Mannich base oxovanadium compound

“…Many vanadates display insulin-mimetic activities, and others present antitumoral effects (Baran, 1997). To develop new vanadium derivatives with improved bioavailability and decreased toxic side effects, some efforts have been made using organic ligands for modification (Baran, 1997(Baran, , 2003Morinville et al, 1998;Thompson and Orvig, 2001;Rehder, 2003;Mukherjee et al, 2004).…”