Flavonol robinobiosides and rutinosides from Alternanthera brasiliana (Amaranthaceae) and their effects on lymphocyte proliferation in vitro

Abstract

O extrato da espécie medicinal Alternanthera brasiliana Kuntze forneceu seis derivados die triglicosilados de kaempferol e quercetina. As estruturas foram elucidadas com base em RMN de 1 H e 13 C. Os seis flavonóides são inéditos no gênero. Kaempferol 3-O-robinobiosídeo e kaempferol 3-O-rutinosídeo inibiram mais eficientemente a proliferação de linfócitos humanos in vitro. The extract of the medicinal species Alternanthera brasiliana Kuntze afforded six di-and triglycosyl kaempferol and quercetin derivatives. Their structures were elucidated based on the 1 Hand 13 C-NMR data and are reported here for the first time in this genus. Kaempferol 3-O-robinobioside and kaempferol 3-O-rutinoside significantly inhibited the human lymphocyte proliferation in vitro.

Health promoting properties of Alternanthera brasiliana leaves and Hibiscus sabdariffa calyces used in fortification of maize-bambara groundnut malt and maize-cowpea malt complementary foods

“…This could be attributed to its higher total flavonoid content (69,034 mg/kg quercetin equivalent); higher flavonols (50,430 mg/kg quercetin equivalent) content compared to the total flavonoid (57,810 mg/kg quercetin equivalent) and total flavonols (8,710 mg/kg quercetin equivalent) of H. sabdariffa. Brachado et al (2003) identified six flavonoids in A. brasiliana leaf extract, out of which 3 inhibited lymphocyte proliferations. The high nitric oxide scavenging activity of the extracts suggests that the extracts be used in preventing inflammation, carcinomas and other diseases caused by nitric oxide radicals derived from cellular by-products as nitric oxide radical is known to play an important role in various inflammatory processes such as carcinomas, juvenile diabetes, multiple sclerosis, arthritis and ulcerative colitis (Hazra et al, 2008).…”

Pigment production and growth of Alternanthera plants cultured in vitro in the presence of tyrosine

“…The major A. tenella components that have been studied are tannins, saponins, flavonoid glycosides and heterosides, such as isorhamnetin, quercetin and kaempferol (Biella et al 2008), as well as other flavonoids, including vitexin and acacetin (Salvador et al 2006). Studies on the chemical composition of species of Alternanthera showed the presence of betalains, betacyanins, betaxanthins, chromo-alkaloids and flavonoids (Brochado et al 2003;Cai et al 2005;Salvador et al 2006). Betalains are N-heterocyclic natural pigments that are derived from the amino acid tyrosine.…”

Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model

“…The plant is used against inflammation, cough, and diarrhea in Brazilian popular medicine. [2] The extracts of A. brasiliana exhibited anti-nociceptive effects in mice, [3] antimicrobial effect, [4] and also anti-herpes simplex virus activity. [5] Aqueous or ethanolic extracts of A. brasiliana are able to block human mitogeninduced lymphocyte proliferation without any toxic effect.…”