Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model

Barua, Chandana Choudhury; Begum, Shameem Ara; Sarma, D. K.; Pathak, Devendra; Borah, R. C.

doi:10.4103/0976-0105.105336

Cited by 30 publications

(38 citation statements)

References 5 publications

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“…Increase in stress tolerance capacity of the animals indicates the possible involvement of higher centre (Omeh and Ezeja, 2010). Therefore, the overall result obtained suggested that the aqueous extract of the leaves of Microtrichia perotitii had antinociceptive activity in the hotplate test that may be in part mediated by opoid receptors and therefore can relieve pain which equally justify the use of the plant for toothaches (Barau et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Phytochemical Screening and Analgesic Activity of Aqueous Extract of The Leaves of Microtrichia perotitii Dc (Asteraceae) in Mice using Hotplate Method

Abdullahi¹,

Ilyas²,

Ibrahim³

2013

mpr

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Currently, available drugs for the management of pains, fever and inflammation conditions presents with it many known adverse effects, hence the search for new drugs from plants which hitherto may be harmless to humans. To this end, Microtrichia perotitii (Asteraceae) was screened for its phyto contents and analgesic properties using hotplate method with mice. The result of the preliminary Phytochemical studies revealed the presence of tannins, flavonoids, saponins, alkaloids, carbohydrates and phenolics in the plant as a whole. The analgesic study showed that the aqueous extract of the leaves have significant activity (P<0.05; P<0.001) as compared to morphine sulphate (10 mg/kg) used as a standard drug. The result indicated dose-independed activity. Tannins, flavonoids, alkaloids and saponins have been reported to be responsible for the analgesic and anti-inflammatory activities in many medicinal plants of this family. These results may explain the use of the plant for the management of pains and its related ailments in the locality where it is very common.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Phytochemical Screening and Analgesic Activity of Aqueous Extract of The Leaves of Microtrichia perotitii Dc (Asteraceae) in Mice using Hotplate Method

Abdullahi¹,

Ilyas²,

Ibrahim³

2013

mpr

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“…A standard wound of uniform 2 cm diameter was formed with the aid of a round seal [21][22][23][24] . The treatment to the excision wounds of the rats was the same as described above.…”

Section: Excision Wound Modelmentioning

confidence: 99%

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

Murti

Kumar²

2012

Asian Pacific Journal of Tropical Biomedicine

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“…The thin sections were cut and stained with haematoxylin and eosin (Vinothapooshan and Sundar, 2010;Adiga et al, 2010;Barua et al, 2009) and observed under microscope for the histopathological changes such as fibroblast proliferation, collagen formation.…”

Section: Histopathological Examinationsmentioning

confidence: 99%

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF MORUS ALBA L. IN ALBINO RATS

Kaushik¹

2013

American Journal of Pharmacology and Toxicology

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To establish the wound healing activity of aqueous and ethanolic extract of roots of Morus alba. Two models were performed to evaluate the wound healing activity i.e., Incision and Excision model. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization was established for both the extracts. Reference standard drug was Aloe vera ointment for comparison with other groups. From the observation in both the models, Aq. extract of Morus alba was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization was highest in excision model compared with other groups. In conclusion, our findings suggest that aq. extract of Morus alba possess better healing ability than the ethanolic extract.

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Healing efficacy of methanol extract of leaves of Alternanthera brasiliana Kuntze in aged wound model

Cited by 30 publications

References 5 publications

Evaluation of Phytochemical Screening and Analgesic Activity of Aqueous Extract of The Leaves of <i>Microtrichia perotitii</i> Dc (Asteraceae) in Mice using Hotplate Method

Evaluation of Phytochemical Screening and Analgesic Activity of Aqueous Extract of The Leaves of <i>Microtrichia perotitii</i> Dc (Asteraceae) in Mice using Hotplate Method

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

EXPLORATION OF HEALING PROMOTING POTENTIALS OF LEAVES OF <i>MORUS ALBA</i> L. IN ALBINO RATS

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