Kaurene diterpenes and other chemical constituents from Mikania stipulacea (M. Vahl) willd

Abstract

foram identificadas com base na análise dos espectros de IV, EM e RMN de 1 H e 13 C.Phytochemical study of Mikania stipulacea yielded lupeol, α-amyrin, stigmasterol, β-sitosterol, campesterol, β-sitosteryl glucopyranoside, stigmasteryl glucopyranoside, the coumarin isoscopoletin, and vanillic, cinnamoylgrandifloric and ent-kaurenoic acids, besides two new diterpene acids : ent-9α-hydroxy-15β-E-cinnamoyloxy-16-kauren-19-oic and ent-9α-hydroxy-15β-Z-cinnamoyloxy-16-kauren-19-oic. IR, 1 H and 13 C NMR and MS spectroscopic analyses were used for the identification of these compounds.

Hyphal Morphology and Elongation Alterations in <i>Aspergillus nidulans</i> Provoked by the Diterpene Kaurenoic Acid

“…According to Kafer [18] in A. nidulans, microtubules and the Rho Cdc42 pathways regulate the formation of a stable axis of hyphal polarity. In A. niger RhoA GTPase is crucial for polarity establishment and polarity [19] and in mammalian the maintenance of arterial tone requires Ca 2+ channel-dependent RhoA activation [20].…”

Genus Mikania: chemical composition and phytotherapeutical activity

“…These compounds have been detected in the aerial parts and are found in the species M.micrantha (Herz et al, 1975;Nicollier & Thompson, 1981), M. glomerata (Barbosa et al, 1994), M. cordata (Kiang et al, 1968;Aguinaldo et al, 1995), M. cordifolia , M. minima (Cuenca & Catalán, 1990), M. hoehnei (Chaves & Oliveira, 2003), M. grazielae (Bohlmann et al, 1982b), M. pseudohoffmanniana , M. (Nascimento & Oliveira, 2001;Nascimento et al, 2004) and M. pohlii (Bohlmann et al, 1982a).…”

Phytochemical study of Mikania pseudohoffmanianna G. M. Barroso ex W. C. Holmes

“…Acid diterpenes of kaurenes bulk (ent-15β-E-cinnamoyloxy-kaur-16-en-19-oic, ent-15β-Z-cinnamoyloxy-kaur-16-en-19-oic and ent-kaur-16-en-19-oic acids) were identified by IR, 1 H and 13 C NMR spectra and the data were compared with thoses reported in the literature (Silverstein et al, 1994;VichnewskiI et al, 1977;Reed et al, 1993;Velandia et al, 1998;Ohno et al, 1979;Yamasaki et al, 1976). Scopoletin coumarin was identified by IR, 1 H and 13 C NMR spectra and mass espectometry and the data were compared with the ones found in literature (Dean, et al, 1967;Nascimento, Oliveira, 2001 C NMR spectra and mass espectometry and the data were compared with thoses reported in the literature (Pauli et al, 1998;Merfort, 1992;Sánchez-Rabaneda, et al, 2003;Santos, 2004;Harborne, et al, 1986;Fabre, et al;Erlend, Dag, 2002).…”