Gestantes colonizadas pelo Streptococcus do grupo B e seus recém-nascidos: análise crítica da conduta adotada no Instituto Fernandes Figueira, Fundação Oswaldo Cruz

Costa, Natalie Del-Vecchio Lages; Carvalho, Manoel de; Pone, Sheila Moura; Júnior, Saint Clair Gomes

doi:10.1590/s0103-05822010000200005

Cited by 7 publications

(7 citation statements)

References 25 publications

(17 reference statements)

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“…Many of the swabs were not collected in the recommended time frame during the prenatal period, which could underestimate the incidence of positive cultures. In these conditions, the incidence of sepsis was higher in newborns from mothers in which intrapartum antibiotic prophylaxis was not done properly [63].…”

Section: Gbs Neonatal Sepsismentioning

confidence: 99%

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

et al. 2019

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Brazilian data for maternal GBS colonization shows different prevalence rates. This conflicting data may be related to the absence of an official recommendation from the Federal Brazilian Health Authorities describing guidelines and protocols to perform GBS screening in pregnant women, in both public and private clinics. In the present review, we evaluated published reports addressing the prevalence of GBS in different regions of the country, methods used, and, when available, information regarding antibiotic resistance and serological typing of clinical isolates. According to this review, GBS prevalence in pregnant women in Brazil ranged from 4.2 to 28.4%, in the last 10 years. Serotype Ia was the most prevalent. The highest antibiotic resistance rates were found for tetarcycline, although its use to treat GBS infections is not common. Our results also show high resistance rates to clindamycin and erythromycin, which are commonly used as an alternative to penicillin in GBS infecctions. The increased antibiotic resistance, variations in serotype distribution, and high GBS prevalences need to be further investigated. Based on the present situation, recommendations regarding GBS surveillance in the country were raised and may improve our strategies for preventing neonatal infections.

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Section: Gbs Neonatal Sepsismentioning

confidence: 99%

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

et al. 2019

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“…Studies investigating GBS in vaginal samples alone detected prevalence rates ranging between 11% and 19.8%, whereas recto-vaginal cultures reveal higher colonization rates, varying between 22% and 29.5% 8,[23][24][25] . In this study, the GBS isolation rates increased by 18.4% and 20.5% for the culture and PCR methods, respectively, when perianal samples were included in the analysis.…”

Section: Tablementioning

confidence: 99%

Group B Streptococcus detection in pregnant women via culture and PCR methods

Wollheim

Sperhacke

Fontana

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Group B Streptococcus (GBS), a source of neonatal infection, colonizes the gastrointestinal and genitourinary tracts of pregnant women. Routine screening for maternal GBS in late pregnancy and consequent intrapartum antibiotic prophylaxis have reduced the incidence of early-onset GBS neonatal infection. The aim of this study was to evaluate the performance of PCR, compared to culture (gold standard), in GBS colonization screening of pregnant women, and to establish the prevalence of GBS colonization among this population. Methods: Vaginal introitus and perianal samples were collected from 204 pregnant women, between the 35 th and 37 th weeks of pregnancy, at the Obstetrics and Gynecology Unit of the University of Caxias do Sul General Hospital between June 2008 and September 2009. All samples were cultured after enrichment in a selective medium and then assayed by culture and PCR methods. Results: The culture and PCR methods yielded detection rates of vaginal/perianal GBS colonization of 22.5% and 26%, respectively (sensitivity 100%; specificity 95.6%; positive and negative predictive values 86.8% and 100%, respectively). A higher prevalence of GBS colonization was detected in the combined vaginal and perianal samples by both culture and PCR assay analyses. Conclusions: PCR is a faster and more efficient method for GBS screening, allowing for optimal identification of women who should receive intrapartum antibiotic prophylaxis to prevent newborn infection.

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“…Estudos prévios no Rio Grande do Sul observaram prevalências de 15,2%, 22,5%, 23,4% e 40% [12][13][14][15]. Em contrapartida, estudos em outras regiões brasileiras apresentaram percentuais de 4,2% em Sobral/CE [16] e 4,7% no Rio de Janeiro/RJ [17], percentuais esses mais próximos ao deste estudo. De forma geral, a prevalência da colonização por S. agalactiae em gestantes brasileiras varia de 4,2% a 40% [12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Discussionunclassified

Suscetibilidade antimicrobiana de Streptococcus agalactiae isolados de gestantes em um hospital materno infantil de Porto Alegre, Rio Grande do Sul

Battistin¹,

Mott²,

Dias³

et al. 2018

Sci Med

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AIMS: To characterize the antimicrobial susceptibility profile of Streptococcus agalactiae isolated from pregnant women attended at a public hospital.METHODS: The study was carried out in a public maternal and child hospital in Porto Alegre, RS, Brazil, in which the screening for S. agalactiae in pregnant women is part of the obstetrics routine. The study was carried out on anal/vaginal swab tests performed from July 2015 to February 2016. Bacterial isolates were identified by phenotypic tests, and the susceptibility to ampicillin, clindamycin, erythromycin and ofloxacin was determined. The erythromycin resistance genes ermB and mefA were also investigated.RESULTS: A total of 294 samples were included, and of these, 26 (8%) were positive for S. agalactiae. All isolates were susceptible to ampicillin, and resistance to erythromycin (21.4%), clindamycin (14.3%) and ofloxacin (7.1%) were observed. The mefA genotype was observed in 66% of the erythromycin resistant isolates.CONCLUSIONS: Results of this study corroborate the consensus that in pregnant women colonized with S. agalactiae, intrapartum antibiotic prophylaxis with penicillin G or ampicillin is indicated. The relevant proportion of isolates resistant to erythromycin and clindamycin, indicated for intrapartum antibiotic prophylaxis in case of allergy to beta-lactam antibiotics, emphasizes the importance of determining the profile of antimicrobial susceptibility of these isolates, a measure that is not yet part of routine prenatal tests in many institutions.

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Gestantes colonizadas pelo Streptococcus do grupo B e seus recém-nascidos: análise crítica da conduta adotada no Instituto Fernandes Figueira, Fundação Oswaldo Cruz

Cited by 7 publications

References 25 publications

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance

Group B Streptococcus detection in pregnant women via culture and PCR methods

Suscetibilidade antimicrobiana de Streptococcus agalactiae isolados de gestantes em um hospital materno infantil de Porto Alegre, Rio Grande do Sul

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