The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats

Öztürk, Barçın; Kurtoğlu, Tünay; Durmaz, Selim; Kozacı, Leyla Didem; Abacıgil, Filiz; Ertuğrul, Mustafa Bülent; Erel, Özcan

doi:10.1590/s0102-865020170030000006

Cited by 10 publications

(6 citation statements)

References 31 publications

(40 reference statements)

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“…At the moment, ozonated vegetable oils are used externally for the management and prevention of various skin diseases [12]. The pathological conditions that benefit from this type of treatment are infectious skin diseases, abscesses and athlete's foot [50][51][52][53], allergic diseases, such as atopic dermatitis, eczema, urticarial and prurigo [54,55], erythema scaly diseases, such as psoriasis and palmoplantar pustulosis [56,57], wound healing, and ulcer recovery [58].…”

Section: Topical Applications Of Ozonated Oilsmentioning

confidence: 99%

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ugazio

Tullio²,

Binello

et al. 2020

Molecules

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The search for a wide spectrum of antimicrobial agents that can avoid resistance while maintaining reasonable side effects has led to ozonated oils experiencing an increase in scientific interest and clinical applications. The treatment of vegetable oils with ozone leads to the creation of a reservoir of ozone that slowly releases into the skin thanks to the fact that ozone can be held as ozonides of unsaturated fatty acids. Interest in the use of ozonated oils has meant that several ozonated-vegetable-oil-containing products have been commercialized as cosmetic and pharmaceutical agents, and in innovative textile products with antibacterial activity. New approaches to the delivery of ozonated oils have very recently appeared in an attempt to improve their characteristics and reduce drawbacks, such as an unpleasant odor, high viscosity and undesired effects on skin, including irritation and rashes. The present review focuses on the current status of delivery agents that use ozonated oils as antimicrobial agents in topical (dermal, skin, and soft tissues) treatments. Challenges and future opportunities for these delivery systems will also be discussed.

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Section: Topical Applications Of Ozonated Oilsmentioning

confidence: 99%

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ugazio

Tullio²,

Binello

et al. 2020

Molecules

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“…Ozone is a triatomic gaseous molecule that acts as a powerful oxidant and has been used in medicine for more than 150 years ( Elvis and Ekta, 2011 ). Ozone has broad medical applications due to its effective antimicrobial function ( Ozturk et al, 2017 ) and antioxidant defense ( Delgadoroche et al, 2017 ). Gram-negative bacteria are more sensitive to ozone than are Gram-positive bacteria, and bacteria are more sensitive than a yeast strain tested ( Moore et al, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Disinfectants on Bacterial Aerosol Diversity in Poultry Houses

Jiang

Tang

et al. 2018

Front. Microbiol.

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To better understand the effect of different disinfectants on the types and quantities of microorganisms in a broiler chicken house, five different types of disinfectants, including ozone, available chlorine, quaternary ammonium salt, glutaraldehyde, and mixed disinfectant, were used. The broiler house microbial communities were analyzed by high-throughput sequencing combined with air sampling. The results showed that the concentrations of airborne aerobic bacteria in the empty broiler houses after application of different disinfectants were significantly reduced compared to a house untreated with disinfectant (P < 0.05 or P < 0.01), and the number of inhalable particles of airborne aerobic bacteria sharply decreased after disinfection. Of the five disinfectants, the mixed disinfectant had the best disinfection efficacy on the total microbial communities (P < 0.05). A total of 508,143 high-quality sequences were obtained by high-throughput sequencing, which identified 1995 operational taxonomic units. In total, 42 phyla and 312 genera were identified. The structures of airborne microbial communities in the broiler houses after the different disinfectants were applied differed. In the house treated with the mixed disinfectant, the microbial communities containing opportunistic pathogens, such as Escherichia-Shigella, Bacillus, and Pseudomonas, had the lowest abundance, with a significant decrease compared to the house untreated with disinfectant. The alpha diversity index showed low diversity of the microbial communities in the house treated with mixed disinfectant. In contrast to the other four disinfectants, only a small amount of bacteria was detected in the air sample in the house treated with the mixed disinfectant; specifically, only four phyla were found (Proteobacteria, Bacteroidetes, Actinobacteria, and Firmicutes). The mixed disinfectant produced a positive effect on disinfection for four phyla; however, it didn’t thoroughly eliminate them. At genus level, Bacillus, Arenimonas, and Shinella could not be detected in the house treated with the mixed disinfectant, but were detected in houses treated with other disinfectants. The high-throughput sequencing results revealed that the combination of multiple disinfectants exhibited a good disinfection efficacy and that this technique could disinfect the air of broiler houses. These results will help guide the development of a reasonable program for broiler house disinfection.

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“…Ozone has wide medical applications due to its effective antimicrobial function (Ozturk et al, 2017), antioxidant defense and the anticipation in wound healing (Delgado-Roche et al, 2017;Elvis and Ekta, 2011;Mirowsky et al, 2016) and in the control of bleeding (Gupta and Mansi, 2012). The effects on immunoregulation and antioxidant defenses, as well as the effectiveness of ozone therapies, have been gradually recognized, although the mechanisms involved in various conditions are still unclear.…”

Section: Uses Of Ozonementioning

confidence: 99%

“…Ozone therapy is considered an alternative therapy and has several positive effects, but depending on the dose, it may result in harmful effects for the individual (Travagli et al, 2010). The primary reported effects in humans are based on three main functions: Antimicrobial (Ozturk et al, 2017), in the antioxidant/oxidant balance (Calunga et al, 2012) and immunomodulatory effects (Zeng and Lu, 2018) (Fig. 1).…”

Section: Multiple and Systemic Sclerosismentioning

confidence: 99%

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

Pivotto¹,

Banhuk²,

Staffen³

et al. 2020

OnLine Journal of Biological Sciences

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Ozone was discovered over a hundred years ago and since then, it has been widely used in many areas, with the primary use as a disinfectant in various ways, but with applications in diverse conditions. More recently, the use of ozone has extended to other fronts, using it to treat different pathologies. Extensive studies have shown its effects, as well as the safety of its application in various modalities of use. Other studies showed its toxicity, which depends on the doses of use. Emerging evidence revealed that ozone also plays an important role in the wound healing and modulation of immune cells, describing the molecular pathways responsible for these actions and describing therapeutic actions in the treatment of wounds, pain, postoperative and infectious diseases. Ozone use has already been documented in different doses, forms of use and routes of application, depending on the clinical situation and an adaptation is necessary for a better result. Thus, this review summarizes the main clinical uses of ozone, presenting the molecular pathways responsible for its actions, as well as discussing the main routes of use, doses and, vehicles used in the clinic.

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The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats

Abstract: We didn't observe any benefit of the agent on MRSA elimination in our model. Likewise, effects of ozone on thiol-disulphide homeostasis and inflammatory cytokines were contradictory.

Cited by 10 publications

References 31 publications

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

Effect of Different Disinfectants on Bacterial Aerosol Diversity in Poultry Houses

Clinical Uses and Molecular Aspects of Ozone Therapy: A Review

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