Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats

Barros, Pedro Paulo; Gonçalves, Gisele Mara Silva; Silva, Gustavo Henrique da; Bastos, Maria Clara Villaça Dias; Ramos, Loren Nogaroto; Fernandes, Marilia Marinello

doi:10.1590/s0102-865020170030000003

Cited by 4 publications

(6 citation statements)

References 29 publications

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“…Three animals remained in each box with free access to tap water. All animals were allowed to acclimatize for a week, followed by randomization and allocation (8)(9)(10)(11)(12) . There were two groups (n=12): rutin group (G1) received suspension 40 mg rutin /kg/day for 10 days, prior to the performance of partial hepatectomy, administered orally (gastric gavage).…”

Section: Methodsmentioning

confidence: 99%

“…The removal of almost 70% of the liver tissue was performed after a 12-hour fast and administering anesthesia with high dose of xylazine and ketamine solution via intraperitoneal (8)(9)(10)(11)(12) . A sensitivity test was performed on the lower and upper limbs before the start of the surgical procedure.…”

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

“…Euthanasia was performed by deepening anesthesia. All the histological analyses were performed in an optic microscope by counting the number of mitoses and apoptosis and observing the general appearance of the liver tissue (8)(9)(10)(11) .…”

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

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Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Barros

Eisinger

Gonçalves

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. OBJECTIVE: This study investigated the effect of rutin oral administration on Wistar rats submitted to hepatic hyperplasia after partial hepatectomy (PH). METHODS: To achieve this, we considered the analysis of hepatic hyperplastic and plasma biochemical activity of Wistar rats, subjected to treatment with rutin 40 mg/kg/day for 10 days in group 1 (G1) or saline in group 2 (G2), followed by partial hepatectomy. RESULTS: The results indicated an increase in the number of mitoses after 24 hours and 48 hours (P=0.0022 and P=0.0152, respectively) of PH in the group that received rutin, as well as an increase in AST serum levels after 24 hours (P=0.0159) and 48 hours (P=0.0158) and alkaline phosphatase after 24 hours (P=0.015) in the same group, in relation to the respective controls. The group that received rutin showed a more evident variation than the control group when comparing the 24 hour and 48 hour results regarding AST, number of mitoses and number of apoptosis (P<0.005). CONCLUSION: It was concluded that rutin intervened in hepatic hyperplasia after 24 hours and 48 hours of PH, favoring hepatic hyperplasia.

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Section: Methodsmentioning

confidence: 99%

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

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Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Barros

Eisinger

Gonçalves

et al. 2020

Arq. Gastroenterol.

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“…Several studies have shown evidence that oxidative stress may contribute to the pathogenesis of AD through the formation of oxygen free radicals. Thus, the therapeutic focus has also been directed towards the use of antioxidants in the treatment of AD [10,48].…”

Section: Resveratrolmentioning

confidence: 99%

“…Although antioxidants do not provide objective improvement in cognition, they can delay the natural evolution of the disease due to their supposed neuroprotective effect [48]. Polyphenols from food consumption plants have already been confirmed as neuroprotective compounds, including by a reduction on the aggregation of β-amyloid protein, such is the case of the trans-3,5,4′-trihydroxystylbene, Resveratrol [12].…”

Section: Resveratrolmentioning

confidence: 99%

Therapeutic Approaches for Alzheimer’s Disease: New Perspectives

Kerppers¹,

Hosni²,

Miri³

et al. 2022

Amyloidosis - History and Perspectives

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Alzheimer’s disease (AD) was defined as a neurodegenerative disorder, being more affected in the elderly. It is estimated that every 3.2 seconds a person in the world is affected by the high disease that rate in 2050 to 1 second. Therefore, research has been carried out on new therapeutic approaches, such as Transcranial Photobiomodulation and treatment based on antioxidants, such as Resveratrol. Therefore, the objective is to conduct a literature review on these two approaches and their effects on the treatment of AD. It was carried out according to the PRISMA recommendation and the articles were selected according to the years of publication (between 2015 and 2020) and extracted from the following databases: Science Direct, PubMed PMC, Scopus, PubMed NCBI, SciELO, LILACS, MEDLINE and PEDro. In several studies it has been reported that both therapies provide improvements at the molecular and behavioral level, recovering brain functions, acting in a neuroprotective way, improving quality of life, with few adverse effects and in a less invasive way. Thus, both treatments have numerous benefits that can be useful in the treatment of AD. However, there is a need for further research that includes interventions with greater specificity and control, so that they are defined as ideal doses and treatment protocols.

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