Protective effect of resveratrol on citrullinemia type I-induced brain oxidative damage in male rats

Delmonego, Larissa; Maia, Thayna Patachini; Magro, Débora Delwing‐Dal; Vincenzi, Karine Louize; Lima, Aline Barbosa; Pscheidt, Luana Carla; Eger, Letícia; Lima, Daniela Delwing de

doi:10.1007/s11011-020-00655-7

Cited by 1 publication

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“…It is fully demonstrated that the oxidative stages promote the significant generation of ROS, affecting the metabolic and physiological functions of neurons (Van Hau et al., 2019; Zou et al., 2018). Oxidative stress in aging causes a decrease in neurocommunication, deteriorating neuronal plasticity and inducing dendritic hypotrophy of the frontal cortex, hippocampus, and cerebellum (Delmonego et al., 2021; Monserrat Hernández‐Hernández et al., 2016). The brain is susceptible to oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Chronic resveratrol administration reduces oxidative stress and brain cell loss and improves memory of recognition in old rats

Juárez

Arteaga

Cortes

et al. 2023

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The cognitive functions of people over 60 years of age have been diminished, due to the structural and functional changes that the brain has during aging. The most evident changes are at the behavioral and cognitive level, with decreased learning capacity, recognition memory, and motor incoordination. The use of exogenous antioxidants has been implemented as a potential pharmacological option to delay the onset of brain aging by attenuating oxidative stress and neurodegeneration. Resveratrol (RSVL) is a polyphenol present in various foods, such as red fruits, and drinks, such as red wine. This compound has shown great antioxidant capacity due to its chemical structure. In this study, we evaluated the effect of chronic RSVL treatment on oxidative stress and cell loss in the prefrontal cortex, hippocampus, and cerebellum of 20‐month‐old rats, as well as its impact on recognition memory and motor behavior. Rats treated with RSVL showed an improvement in locomotor activity and in short‐ and long‐term recognition memory. Likewise, the concentration of reactive oxygen species and lipid peroxidation decreased significantly in the group with RSVL, coupled with an improvement in the activity of the antioxidant system. Finally, with the help of hematoxylin and eosin staining, it was shown that chronic treatment with RSVL prevented cell loss in the brain regions studied. Our results demonstrate the antioxidant and neuroprotective capacity of RSVL when administered chronically. This strengthens the proposal that RSVL could be an important pharmacological option to reduce the incidence of neurodegenerative diseases that affect older adults.

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