Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats

Romero, Gustavo Tominaga; Santos, Carlos Henrique Marques dos; Cassino, Pedro Carvalho; Odashiro, Maçanori; Seno, Gisele Zocoller; Aléssio, Gabriela Flávia

doi:10.1590/s0102-865020160060000003

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The mismatch of metallic and soft materials can erode soft tissues and lead to perforation and local inflammation (1)(2)(3)(4)(5). The replacement of rigid metallic tethering with flexible biomaterials is desirable, but the lack of on-demand tissue adhesives often necessitates traumatic anchoring with sutures or hooks, which causes additional mechanical trauma to the underlying tissues (6)(7)(8). Tissue adhesives and polymeric hydrogels have the potential to allow for atraumatic anchoring by providing stress distribution at the interface, but most existing designs are incapable of on-demand activation, especially with minimally invasive catheters.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive electroceutical catheter for endoluminal defect sealing

et al. 2021

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Surgical repair of lumen defects is associated with periprocedural morbidity and mortality. Endovascular repair with tissue adhesives may reduce host tissue damage, but current bioadhesive designs do not support minimally invasive deployment. Voltage-activated tissue adhesives offer a new strategy for endoluminal repair. To facilitate the clinical translation of voltage-activated adhesives, an electroceutical patch (ePATCH) paired with a minimally invasive catheter with retractable electrodes (CATRE) is challenged against the repair of in vivo and ex vivo lumen defects. The ePATCH/CATRE platform demonstrates the sealing of lumen defects up to 2 millimeters in diameter on wet tissue substrates. Water-tight seals are flexible and resilient, withstanding over 20,000 physiological relevant stress/strain cycles. No disruption to electrical signals was observed when the ePATCH was electrically activated on the beating heart. The ePATCH/CATRE platform has diverse potential applications ranging from endovascular treatment of pseudo-aneurysms/fistulas to bioelectrodes toward electrophysiological mapping.

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Section: Introductionmentioning

confidence: 99%

Minimally invasive electroceutical catheter for endoluminal defect sealing

et al. 2021

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“…FISTULA-IN-ANO surgery has been performed for decades however, definitive management is still a challenge for surgeons because risks of recurrence and incontinence are still not uncommon. This made the surgeons move to less aggressive techniques such as fistula glue and collagen plug [1][2][3][4][5] . Recurrence rate after these procedures is still not satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fistula in Ano Surgery on Anorectal Manometric Study

Mohamed¹,

Farag

2018

The Medical Journal of Cairo University

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Background: Surgical treatment of anal fistula is associated with a significant risk of impaired continence. Anorectal manometry is the most widely available tool for investigating anorectal function.Patients and Methods: Twenty patients of age ranging from twenty to sixty years old underwent treatment of anal fistula. They did anorectal manometry before and two months after management.Results: Significant decrease noted in the resting and squeezes pressure and maximal tolerable volume in the rectum. Conclusion:Anorectal manometry is a valuable tool in detecting the effect of anal fistula surgery on anorectal function even in subclinical conditions that may be helpful in opening the way for studies predicting high risk patient after anal fistula surgery to start treatment before reaching the clinical condition.

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Collagen treatment of complex anorectal fistula: 3 years follow-up

et al. 2023

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Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should be considered for complex fistulas. One of the sphincteric preserving treatment is the filling with a dermal extract commonly called “collagen glue” as Salvecoll-E® gel. This is a multicentric, prospective, observational study on the use of Salvecoll-E® gel in treatment of complex anal fistulas. We treated 70 patients from May 2016 to May 2017. In the first phase, we debrided the fistula tract using a loose seton kept for 4–6 weeks. In the second phase, the seton was removed and the fistula tract was filled with Salvecoll-E® gel. In this article, we report results at 36 months of follow-up. Fifty patients (71.4%) had completely healed fistula within 36 months of follow-up. Twenty-eight patients (28.2%) had recurrences. Among these failures, 65% were within 6 months. All low transphincteric fistulas healed. Recurrences occurred only in median and high transphincteric fistulas. No patient had a worsening of continence status measured with Cleveland Clinic Florida Incontinence Severity score. Salvecoll-E® gel is a recent finding among sphincter-sparing treatments. In this study, we demonstrate that it is a safe option in the treatment of complex fistulas. Final results are satisfactory and in line with the best results published in literature among mini-invasive treatments.

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Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats

Cited by 3 publications

References 16 publications

Minimally invasive electroceutical catheter for endoluminal defect sealing

Minimally invasive electroceutical catheter for endoluminal defect sealing

Effect of Fistula in Ano Surgery on Anorectal Manometric Study

Collagen treatment of complex anorectal fistula: 3 years follow-up

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