Effects of cilostazol in kidney and skeletal striated muscle of Wistar rats submitted to acute ischemia and reperfusion of hind limbs

Abstract

Cilostazol had no protective effect on the kidney and the skeletal striated muscle in rats submitted to acute ischemia and reperfusion in this model.

Effects of dietary creatine supplementation on kidney and striated skeletal muscles of rats submitted to ischemia and reperfusion of hind limbs

“…Muscle histological analysis also showed agreement with renal biochemical and histological results, showing significant differences between G1 and G2 and not between G1 and G3 in the variables hypereosinophilia and muscle fiber karyopyknosis, corroborating for a possible protective effect of creatine supplementation against ischemic injuries in muscle fibers. There were no significant differences between groups in muscle variables (interstitial edema, inflammatory infiltrate and necrosis), perhaps because these changes are more closely related to the time of ischemia and reperfusion 14 . The reduction in muscle damage after creatine supplementation highlighted in the present study agree with the results of the experiment carried out by Cooke et al, which also aimed to evaluate its myoprotective effect, after chemically induced damage, concluding that the muscles supplemented with creatine had a higher proportion of undamaged fibers, as well as larger areas of regenerating fibers 13 .…”

“…Muscle histological analysis also showed agreement with renal biochemical and histological results, showing significant differences between G1 and G2 and not between G1 and G3 in the variables hypereosinophilia and muscle fiber karyopyknosis, corroborating for a possible protective effect of creatine supplementation against ischemic injuries in muscle fibers. There were no significant differences between groups in muscle variables (interstitial edema, inflammatory infiltrate and necrosis), perhaps because these changes are more closely related to the time of ischemia and reperfusion 14 .…”

“…A median laparotomy of 4 cm in length was performed and the aorta was connected immediately below the emergence of the left renal artery with 7.0 propylene suture in animals in groups 1 and 2. The 7.0 propylene sutures were passed around the group 3 animals’ infrarenal aorta, but no ligation was performed to interrupt aortic flow in animals in this group 14 .…”

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits

“…The cost of rat model of ischemia reperfusion injury in limb skeletal muscle is relatively low. Some researchers proposed adopting open surgery and blocking abdominal aorta or iliac artery at the beginning to block blood flow from abdominal aorta or arteria iliaca communis [ 21 ]. And some researcher proposed separating the femoral vein or femoral artery from the groin and blocking blooding flow of branch vessel using rubber tourniquet ligation and using the noninvasive vascular clamp on the femoral artery and vein to block blood flow [ 22 ].…”

Cardioprotective and Anti-Aggregatory Effects of Levosimendan on Isoproterenol-Induced Myocardial Injury in High-Fat-Fed Rats Involves Modulation of PI3K/Akt/mTOR Signaling Pathway and Inhibition of Apoptosis

“…Isoproterenol hydrochloride, cilostazol, and levosimendan (Sigma-Aldrich Chemical Co, Cairo, Egypt) were supplied as a white crystalline powder, off-white powder, and crystalline powder, respectively, and dissolved in saline. Cilostazol was given twice a day orally by gastric tube at a dose of 10 mg/kg, 27 whereas levosimendan was given intrapretioneal (IP) injection once daily at a dose of 24 μg/kg. 14…”