Comparative study of inflammatory response and adhesions formation after fixation of different meshes for inguinal hernia repair in rabbits

Goldenberg, Alberto; Matone, Jacques; Marcondes, Wagner; Herbella, Fernando A. M.; Farah, José Francisco de Mattos

doi:10.1590/s0102-86502005000500002

Cited by 35 publications

(23 citation statements)

References 9 publications

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“…Basically synthetic prosthesis may be made of nylon, polypropylene, polytetrafluorethylene, polyvinyl, acrylonytril, pulp acetate, polyglactin 910, 7 polypropylene bound to synthetic polyglactin. 8 Early studies done by Usher and Wallace 9 showed the validity of polyethylene(Marlex 50®) for the production of surgical meshes of optimal physical properties, being biologically inert and adequate to the surgical treatment of incisional hernias. 10 It is also regarded as useful in the management of recurring incisional hernia.…”

Section: Introductionmentioning

confidence: 99%

Experimental study comparing the tensile strength of different surgical meshes following aponeurotic-muscle deformity synthesis on Wistar rats

et al. 2007

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PURPOSE: To assess the tensile strength of polypropylene and polypropylene associated with polyglactin meshes (Vypro II® - Ethicon®, Somerville, NJ, USA) in a situation of partial separation of abdominal muscle aponeurosis on rats. METHODS: Thirty rats were used of the Wistar strain, which were randomized into two groups of 15 specimens each. In both groups an aponeurotic-muscle deformity was created on the abdominal wall measuring 3.0 x 1.0 cm, which was closed with polypropylene mesh (polypropylene group) or Vypro® mesh (vypro group). After 28 days the rats underwent euthanasia and an area was removed from the abdominal wall with which a strip was made measuring 2.0 cm in length and 6.0 cm in width comprising the abdominal muscles with the implanted mesh. This sample was placed in a mechanical test machine in which a constant force was applied contrary to the tissue strips. Maximum force expressed in Newton was considered until full rupture of the sample occurred. The non-parametric Kruskal - Wallis test was used for statistical analysis admitting p<0.05. RESULTS: Out of the thirty animals, there were two deaths in the vypro group and one unit in the polypropylene group was lost. One animal in the polypropylene group developed hernia during the study and another one developed granuloma of the abdominal wall. All animals in both groups developed epiplon adherence to the mesh. The average force was 48.08 N for the polypropylene group and 45.32 for the vypro® group. CONCLUSION: In these experimental conditions it could be observed that there is no statistically significant difference in the rupture force of the polypropylene and Vypro® meshes (p=0.54).

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Section: Introductionmentioning

confidence: 99%

Experimental study comparing the tensile strength of different surgical meshes following aponeurotic-muscle deformity synthesis on Wistar rats

et al. 2007

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“…adhesions with prostheses in contact with viscera, independent of the type and protection of the mesh [1][2][3] .…”

Section: Resultsmentioning

confidence: 99%

“…Rabbits are used in research to evaluate types of mesh and it is a satisfactory biological model [1][2][3] .…”

Section: Resultsmentioning

confidence: 99%

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May titanium spiral tacks contribute to intra-abdominal adhesion formation?

Goldenberg

Rivas²,

Schvartsman³

2012

Acta Cir. Bras.

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PURPOSE:To verify if titanium spiral tacks may contribute to intra-abdominal adhesion formation in rabbits. METHODS:Ten New Zealand white rabbits were used. Through videolaparoscopic surgery two titanium spiral tacks (ProTack ® , Covidien ® ) were applied in the right flank. After 30 days the animals were submitted to evaluate peritoneal cavity by videolaparoscopy. RESULTS:No adhesion was found where the titanium spiral tacks were placed. CONCLUSION:Titanium spiral tacks for fixation do not cause adhesions in rabbits.

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“…The delay allows the fibrin clots to be invaded by fibroblasts, macrophages, and new blood vessels, thus allowing a maturation of a fibrin clot into tissue adhesions [24][25][26][27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats

Tzanoglou

George²,

Nikolaos

et al. 2016

Acta Cir. Bras.

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Design of the study, critical revision, final approval. ABSTRACT PURPOSE:To evaluate the tissue integration of a double-sided mesh after fixation in diaphragm and to study the diaphragmatic mobility by ultrasound. METHODS:Twenty male Wistar rats were used. The animals were assigned into two equal groups according to the day of euthanasia.The animals were anesthetized and a 1.5 x 1.5 cm of double-layer mesh was inserted between the diaphragm and the liver. For the evaluation of the diaphragm mobility a sonographic method was used. Measurements on specific breathing parameters were taking place. Pathological evaluation took place after the animal's euthanasia. RESULTS:Extra-hepatic granuloma was not differentiated overtime, (χ2=0.04, p>0.05). Neither fibrosis was significantly differentiated, (χ2=0.04, p>0.05). Intra-hepatic granuloma was significantly differentiated overtime, (χ2=10.21, p<0.05). Concerning Te parameter, means were significantly differentiated over time, F (3, 30) = 5.12, (p<0.01). Ttot parameter, it was differentiated over time, F (3, 8)=4.79, (p<0.05). IR parameter was also longitudinally differentiated, F (3, 30)=3.73, (p<0.05). CONCLUSION:The measurements suggest a transient malfunction of diaphragmatic mobility despite the fact that inflammatory reaction, fibrosis and extra-hepatic granuloma were not significantly differentiated with the passage of time.

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Comparative study of inflammatory response and adhesions formation after fixation of different meshes for inguinal hernia repair in rabbits

Abstract: Polypropylene and Vypro mesh, when implanted in the peritoneal cavity of rabbits provoke similar amount of adhesions. Vypro mesh tissues had higher fibrosis resulting in better mesh incorporation to the abdominal wall.

Cited by 35 publications

References 9 publications

Experimental study comparing the tensile strength of different surgical meshes following aponeurotic-muscle deformity synthesis on Wistar rats

Experimental study comparing the tensile strength of different surgical meshes following aponeurotic-muscle deformity synthesis on Wistar rats

May titanium spiral tacks contribute to intra-abdominal adhesion formation?

Evaluation of diaphragmatic mobility following intra-abdominal sub-diaphragmatic fixation of a double-layered mesh in rats

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