The effect of essential oil of Syzygium cumini on the development of granulomatous infl ammation in mice

Machado, Rachel Rocha Pinheiro; Jardim, Deborah F.; Souza, Andrezza Rodrigues De; Scio, Elita; Fabri, Rodrigo Luiz; Carpanez, Arthur G.; Grazul, Richard Michael; Mendonça, Joalice de Oliveira; Lesche, B.; Aarestrup, Fernando Monteiro

doi:10.1590/s0102-695x2013005000030

Cited by 22 publications

(18 citation statements)

References 18 publications

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“…45 The essential oils from Jamun leaf have been reported to alleviate chronic granulomatous inflammation in BALB/c mice that had been intravenously infected with Mycobacterium bovis Bacillus Calmettte-Guerin. 61 The fla- Jagetia GC. Pharmacological activities of Jamun, Syzygium Cumini J Explor Res Pharmacol vonoid fraction of Jamun has been reported to alleviate inflammatory response in human lymphocytes, monocytes and neutrophils against the hepatitis B vaccine.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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“…The oils of S. cumini (L.) Skeels (syn. Eugenia cumini and E. jambolana ) collected in Brazil (Ceará, Maranhão, and Rio de Janeiro states) showed α-pinene (22.2–48.0%) as the main constituent [ 66 , 67 , 68 , 69 ], while another oil of S. cumini collected in Minas Gerais state, Brazil, showed α-humulene (25.2%) and ( E )-caryophyllene (16.0%) as the predominant compounds [ 70 ].…”

Section: Volatile Profilesmentioning

confidence: 99%

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

et al. 2020

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The Eugenia and Syzygium genera include approximately 1000 and 1800 species, respectively, and both belong to the Myrtaceae. Their species present economic and medicinal importance and pharmacological properties. Due to their chemical diversity and biological activity, we are reporting the essential oils of 48 species of these two genera, which grow in South America and found mainly in Brazil. Chemically, a total of 127 oil samples have been described and displayed a higher intraspecific and interspecific diversity for both Eugenia spp. and Syzygium spp., according to the site of collection or seasonality. The main volatile compounds were sesquiterpene hydrocarbons and oxygenated sesquiterpenes, mainly with caryophyllane and germacrane skeletons and monoterpenes of mostly the pinane type. The oils presented many biological activities, especially antimicrobial (antifungal and antibacterial), anticholinesterase, anticancer (breast, gastric, melanoma, prostate), antiprotozoal (Leishmania spp.), antioxidant, acaricidal, antinociceptive and anti-inflammatory. These studies can contribute to the rational and economic exploration of Eugenia and Syzygium species once they have been identified as potent natural and alternative sources to the production of new herbal medicines.

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“…65 The extracts of Andrographis paniculata, Petiveria alliacea, Morinda citrifolia, Acorus calamus L.,Aloe vera, Kaempferia galanga L., and Syzygium cumini (L.) Skeels were also reported that had the ability to suppress the activity of Mycobacterium tuberculosis. [66][67][68][69][70][71]…”

Section: Plants Used For Treating Tuberculosis In Indonesia Provincesmentioning

confidence: 99%

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Aristyani¹,

Widyarti²,

Sumitro³

2018

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Background: Indonesia is the biggest archipelago country with the second biggest biodiversity in the world. A lot of medical plants for treating various diseases can be found in Indonesia, including medical plants for tuberculosis, an infectious disease caused by Mycobacterium tuberculosis. Objective: The goal of this research is to document the information of Indonesia indigenous medical plants that used various local societies to treat tuberculosis and also analyze active compounds of medical plants with proteins that related to tuberculosis. Methods and Materials: The annotation of medical plants for treating tuberculosis was collected from a various source comprising local research papers, theses, and other resources. The information of active compound was taken from Dr. Duke's Phytochemical and Ethnobotanical Databases. A network of active compounds-proteins was analyzed by using Cytoscape 3.6.0. Results: The result described that there were twenty-seven species from nineteen families of medical plants used by local societies of Indonesia for tuberculosis therapy, and there were sundry of active compounds from fourteen medical plants had direct interaction with proteins related tuberculosis. Conclusion: Most of the active compounds targeted proteins that had a prominent role in immune system. It indicated that medical plants treating tuberculosis through regulating immunity of human body. ABSTRACT SUMMARY • Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis. For a long time, Indonesia local societies have been used medical plants for tuberculosis therapy. By using network analysis study, the active compounds of medical plants can modulate human immunity to treat tuberculosis. Sherry Aristyani, a master student of Biology in Faculty of Mathematics and Natural Sciences, University of Brawijaya. Her master research focuses on active compounds of Indonesia medical plants for tuberculosis therapy. Sri Widyarti, Lecturer and researcher in Faculty of Mathematics and Natural Sciences, University of Brawijaya. She has expertise in biology cell. Sutiman Bambang Sumitro, a professor in Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya. He has expertise in biology cell, bioinorganic, and nano-biology. ABOUT AUTHORS

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The effect of essential oil of Syzygium cumini on the development of granulomatous infl ammation in mice

Cited by 22 publications

References 18 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Essentials Oils from Brazilian Eugenia and Syzygium Species and Their Biological Activities

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

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