Assessment of mutagenic, antimutagenic and genotoxicity effects of Mimosa tenuiflora

Silva, Viviane A.; Gonçalves, Gregório Fernandes; Pereira, Mônica Cox de Britto; Gomes, Isis Fernandes; Freitas, A.F.R.; Diniz, Margareth F. F. Melo; Pêssoa, Hilzeth L. F.

doi:10.1590/s0102-695x2013005000014

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…The ethanol extract of the bark of this plant was also effective against Staphylococcus aureus (Padilha et al, 2008;Bezerra et al, 2010). On the other hand, Silva et al (2013) showed no mutagenic activity for the ethanol extract of the bark of M. tenuiflora. Rivera-Arce et al (2007) have shown that a hydrogel containing 5% of a crude ethanol extract of the bark of this plant was useful for the treatment of venous leg ulceration disease in patients.…”

Section: Introductionmentioning

confidence: 85%

Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

Nascimento¹,

Paiva-Souza²,

Fernandes³

et al. 2016

Afr. J. Pharm. Pharmacol.

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This study investigated the antioxidant and anti-inflammatory effects from the inner bark of Mimosa tenuiflora. The hydroethanol extract (HEE) and its hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fractions were prepared and submitted to phytochemical screening and antioxidant activity. In vivo anti-inflammatory effect was investigated by using 12-Otetradecanoylphorbol 13-acetate (TPA)-induced edema and myeloperoxidase (MPO) activity in mice ears. Phytochemical prospection of HEE revealed the presence of flavonoids, tannins, xantones, triterpenes, esteroids and phenols. Higher total phenol content was found in EAF and higher percentages of inhibition of 2,2-diphenyl-1-picrylhydrazyl free DPPH radical were found for HEE, EAF or HMF. Lipid peroxidation (LP) induced by 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) was greatly inhibited by HEE or EAF, while inhibition of FeSO 4-induced LP was higher for HMF. The coadministration of HEE (1 or 3 mg/ear) decreased edema (p<0.001) and MPO activity (p<0.05). All fractions reduced mice ear edema at the same extent, however, while EAF and HMF reduced MPO activity in mice ear at both 1 and 3 mg/ear (p<0.001 and p<0.05 respectively), CLF only at 3 mg/ear (p<0.05) and HXF did not affect this parameter. Taken together, these results demonstrate that inner bark of M. tenuifolia possesses antioxidant and anti-inflammatory effects.

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Section: Introductionmentioning

confidence: 85%

Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

Nascimento¹,

Paiva-Souza²,

Fernandes³

et al. 2016

Afr. J. Pharm. Pharmacol.

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“…The results showed that the extract did not induce mutations in any strain. Further studies of toxicity were performed to investigate the use of this plant in the treatment of diseases [25].…”

Section: Mimosa Tenuiflora (Mt) Extractmentioning

confidence: 99%

Current Trends and Future Perspectives of Antimutagenic Agents

AbdelHakem¹,

Abdelhafez²

2021

Genotoxicity and Mutagenicity - Mechanisms and Test Methods

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Mutation is the process leading to heritable changes in DNA caused mainly by internal and external factors. Recently, studies on mutagenic agents have been increased due to increasing in mutation-related disease. The antimutagenic effect is desired to prevent mutation on genes or to inactivate the mutagenic agent. It seems that the interest in antimutagenic substances displaying multiple mechanisms of action will be an important trend in the research and development of new antimutagenic compounds in the near future. Therefore, this chapter displays various possible mechanisms of action for antimutagenic agent and introduces different types of antimutagens, natural and synthetic, that are considered very important.

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“…Mimosa hostilis, Mimosaceae) naturally grows in North part of South America and in Mexico. It has been traditionally used by the Brazilian Indians for curing infections, inflammations against bronchitis, coughs, headache, external ulcers and also for divination [47,48]. Pharmacological studies showed that M .…”

Section: Illegal Plant Species Descriptionmentioning

confidence: 99%

“…tenuiflora extracts show antimicrobial, antiplasmolytic, anti-inflammatory, hemolytic and wound healing activities [47,49]. It contains diverse classes of secondary metabolites -indole alkaloids, tannins, chalcones, steroids, saponins and flavonoids [48]. There are reports of teratogenic action of M .…”

Section: Illegal Plant Species Descriptionmentioning

confidence: 99%

Psychoactive plants used in designer drugs as a threat to public health

2015

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S u m m a r yBased on epidemiologic surveys conducted in [2007][2008][2009][2010][2011][2012][2013], an increase in the consumption of psychoactive substances has been observed. This growth is noticeable in Europe and in Poland. With the 'designer drugs' launch on the market, which ingredients were not placed on the list of controlled substances in the Misuse of Drugs Act, a rise in the number and diversity of psychoactive agents and mixtures was noticed, used to achieve a different state of mind. Thus, the threat to the health and lives of people who use them has grown. In this paper, the authors describe the phenomenon of the use of plant psychoactive substances, paying attention to young people who experiment with new narcotics. This article also discusses the mode of action and side effects of plant materials proscribed under the

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Assessment of mutagenic, antimutagenic and genotoxicity effects of Mimosa tenuiflora

Cited by 14 publications

References 24 publications

Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

Anti-inflammatory and antioxidant activities of the hydroethanol extract and fractions of the bark of Mimosa tenuiflora (Willd.) Poir.

Current Trends and Future Perspectives of Antimutagenic Agents

Psychoactive plants used in designer drugs as a threat to public health

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