Current Trends and Future Perspectives of Antimutagenic Agents

AbdelHakem, Adel M.; Abdelhafez, Elshimaa M.

doi:10.5772/intechopen.91689

Cited by 3 publications

(5 citation statements)

References 58 publications

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“…Furthermore, BA was able to lead to ATM activation and a DNA damage response of the cells [62]. The observed antigenotoxicity action by the borenium and borinium compounds (Table 3) could also be attributed to their direct chemical interaction before MMC caused genotoxic damage [64]. Previous evidence exerted that antioxidantfeatured substances can eliminate ROS before these reactive chemicals interact with DNA and change in a DNA sequence [64].…”

Section: Synthesis Of Borinium Ionic Liquidsmentioning

confidence: 90%

“…The observed antigenotoxicity action by the borenium and borinium compounds (Table 3) could also be attributed to their direct chemical interaction before MMC caused genotoxic damage [64]. Previous evidence exerted that antioxidantfeatured substances can eliminate ROS before these reactive chemicals interact with DNA and change in a DNA sequence [64]. Consistent with our findings, previous reports suggested that BCCs have antigenotoxic effects against several genotoxic agents, such as titanium, aluminum, aflatoxins, lead, bismuth, arsenic, and cadmium [65].…”

Section: Synthesis Of Borinium Ionic Liquidsmentioning

confidence: 99%

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Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oguzkan,

Turkez,

Ugras

et al. 2023

Inorganics

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In this study, the biological properties of novel borenium and borinium compounds in terms of their oxidative, genotoxic, and cytotoxic effects were assessed on cultured human peripheral blood cells, as well as several types of cancer cells. Our results revealed that the borinium compounds yielded the best results in terms of supporting total antioxidant capacity (TAC). In fact, borenium 1, borenium 2, borenium 3, borinium 4, and borinium 5 compounds elevated TAC levels of cultured human blood cells at rates of 42.8%, 101.5%, 69.8%, 33.3%, and 49.2%, respectively. There were no statistically significant differences (p > 0.05) between the negative control and the groups treated with all borinium and borenium concentrations from the micronucleus (MN) and chromosome aberration (CA) assays, demonstrating the non-genotoxic effects. Moreover, borenium 1 (60.7% and 50.7%), borenium 2 (70.4% and 57.2%), borenium 3 (53.1% and 45.2%), borinium 4 (55.1% and 48.1%), and borinium 5 (51.0% and 36.1%) minimized the mitomycin C(MMC)-induced genotoxic damages at different rates as determined using CA and MN assays, respectively. Again, it was found that the borinium compounds exhibited higher cytotoxic activity on cancer cells when compared to borenium compounds. Consequently, in light of our in vitro findings, it was suggested that the novel borinium and borenium compounds could be used safely in pharmacology, cosmetics, and various medical fields due to their antioxidant and non-genotoxic features, as well as their cytotoxicity potential on cancer cells.

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Section: Synthesis Of Borinium Ionic Liquidsmentioning

confidence: 90%

Section: Synthesis Of Borinium Ionic Liquidsmentioning

confidence: 99%

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oguzkan,

Turkez,

Ugras

et al. 2023

Inorganics

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“…Bio-antimutagens, instead, act after DNA damage, promoting DNA repair or preventing DNA replication [ 84 ]. Antimutagenesis involves different mechanisms, including chemical or enzymatic inactivation of mutagens through the modulation of phase 1 and phase 2 enzymes, prevention of mutagen’s formation, free radical scavenging activity, and antioxidant activity [ 85 , 86 ]. Different studies pointed out that emodin could be classified as a desmutagen agent.…”

Section: Anticancer Mechanisms Of Aqs Isolated From Marine Fungimentioning

confidence: 99%

Marine Anthraquinones: Pharmacological and Toxicological Issues

et al. 2021

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The marine ecosystem, populated by a myriad of animals, plants, and microorganisms, is an inexhaustible reservoir of pharmacologically active molecules. Among the multiple secondary metabolites produced by marine sources, there are anthraquinones and their derivatives. Besides being mainly known to be produced by terrestrial species, even marine organisms and the uncountable kingdom of marine microorganisms biosynthesize anthraquinones. Anthraquinones possess many different biological activities, including a remarkable antitumor activity. However, due to their peculiar chemical structures, anthraquinones are often associated with toxicological issues, even relevant, such as genotoxicity and mutagenicity. The aim of this review is to critically describe the anticancer potential of anthraquinones derived from marine sources and their genotoxic and mutagenic potential. Marine-derived anthraquinones show a promising anticancer potential, although clinical studies are missing. Additionally, an in-depth investigation of their toxicological profile is needed before advocating anthraquinones as a therapeutic armamentarium in the oncological area.

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“…Dietary sources or synthetic compounds that can counteract mutagenic agents as potential anti-mutagens are considered a strategy in cancer chemoprevention and mutation-related diseases. The anti-mutagenic potency, coupled with antioxidant properties, is one of the mechanisms that inhibit mutagenesis [ 23 ]. Our previous study demonstrated the antioxidant ability of chrysin-ES, suggesting that it might exert anti-mutagenic activity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nanomaterials 2024, 14, 1001 2 of 23 Nanoemulsions, fine oil-in-water dispersions, are both kinetically and physically stable for long periods without gravitational separation, flocculation, or coalescence. Nanoemulsions are currently used to administer several medicines, including pharmaceuticals, phytopharmaceuticals, cosmeceuticals, dietary drugs, and nutraceuticals, to improve human health [8].…”

Section: Introductionmentioning

confidence: 99%

Multi-Endpoint Toxicological Assessment of Chrysin Loaded Oil-in-Water Emulsion System in Different Biological Models

Pitchakarn,

Ting,

Buacheen

et al. 2024

Nanomaterials

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Chrysin is hypothesized to possess the ability to prevent different illnesses, such as diabetes, cancer, and neurodegenerative disorders. Nonetheless, chrysin has a low solubility under physiological conditions, resulting in limited bioavailability. In a previous study, we utilized an oil-in-water emulsion system (chrysin-ES or chrysin-NE) to encapsulate chrysin, thereby increasing its bioaccessibility and preserving its antioxidant and anti-Alzheimer’s properties. To promote the chrysin-ES as a supplementary and functional food, it was obligatory to carry out a safety assessment. Cytotoxicity testing showed that chrysin-ES was harmless, with no killing effect on 3T3-L1 (adipocytes), RAW 264.7 (macrophages), HEK293 (kidney cells), and LX-2 (hepatic stellate cells). The acute toxicity evaluation demonstrated that the 50% lethal dose (LD50) for chrysin-ES was greater than 2000 mg/kg BW. Genotoxicity assessments found that chrysin-ES did not induce DNA mutations in vitro or in vivo. Furthermore, chrysin and chrysin-ES exhibited anti-mutagenic properties against PhIP-induced and IQ-induced mutagenesis in the Ames test, while they inhibited urethane-, ethyl methanesulfonate-, mitomycin C-, and N-nitrosomethylurea-mediated mutations in Drosophila. The present study illustrates the safety and anti-genotoxicity properties of chrysin-ES, allowing for the further development of chrysin-based food supplements and nutraceuticals.

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Current Trends and Future Perspectives of Antimutagenic Agents

Cited by 3 publications

References 58 publications

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds

Marine Anthraquinones: Pharmacological and Toxicological Issues

Multi-Endpoint Toxicological Assessment of Chrysin Loaded Oil-in-Water Emulsion System in Different Biological Models

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