Antiproliferative activity of the hexanic extract and phloroglucinols from Hypericum brasiliense

França, Hildegardo Seibert; Rocha, Leandro; Fernande, Caio P.; Ruiz, Ana Lúcia T. G.; Carvalho, João Ernesto de

doi:10.1590/s0102-695x2013000500018

Cited by 6 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The possible mechanism behind the antiproliferative activity in glioblastoma and melanoma cells could be the induction of authophygy [17]. França et al [18] showed that hexane extract and phloroglucinol derivatives obtained from H. brasiliense are potent inhibitors of ovarian (OVCAR-03 and NCIADR/RES) and melanoma (UACC-62) cell division. Three endemic Hypericum species from Canary Islands (H. reflexum, H. canariense and H. grandifolium) showed potent cytotoxic activity against human melanoma cell line (A375), breast adenocarcinoma cell line (MDA-MB 231) and colon cancer cell line (HCT116).…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and New Biological Activities of Essential Oil and Hydrosol of Hypericum perforatum L. ssp. veronense (Schrank) H. Lindb

Vuko

Dunkić

Ruščić

et al. 2021

Plants

View full text Add to dashboard Cite

The chemical profile, antiproliferative, antioxidant and antiphytoviral activities of the species Hypericum perforatum ssp. veronense (Schrank) H. Lindb. (Clusiaceae) were investigated. Free volatiles were isolated and the chemical composition was determined in the lipophilic fraction (essential oil) and for the first time in the water fraction (hydrosol). The aim is to provide phytochemical data for H. perforatum ssp. veronense useful for distinguishing ssp. veronense from ssp. angustifolium, as there are taxonomic disagreements between them and the composition of the secretory products may be helpful in this respect. In the essential oil, the most abundant compounds identified were α-pinene and n-nonane, while in the hydrosol, myrtenol, carvacrol and α-pinene were the most abundant. Overall, the class of monoterpenes and oxygenated monoterpenes dominated in the EO and hydrosol samples. The essential oil showed high antioxidant activity, in contrast to the antiproliferative activity, where the hydrosol showed exceptional activity against three cancer cell lines: Hela (cervical cancer cell line), HCT116 (human colon cancer cell line) and U2OS (human osteosarcoma cell line). Both the essential oil and hydrosol showed antiphytoviral activity against tobacco mosaic virus infection on the local host plants. This is the first report dealing with biological activities of hydrosol of H. perforatum ssp. veronense, and the obtained results suggest that this traditional medicinal plant is a valuable source of volatiles with promising antiproliferative, antioxidant and antiphytoviral activities.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical Composition and New Biological Activities of Essential Oil and Hydrosol of Hypericum perforatum L. ssp. veronense (Schrank) H. Lindb

Vuko

Dunkić

Ruščić

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…Despite numerous studies and publications, Hypericum species are of high-priority research due to the increasing pharmacological significance and commercial value of Hyperici herba, officially obtained from H. perforatum (Stojanovic et al, 2013). Thus, a number of Hypericum species from different countries of the world, such as Brazil (França et al, 2013), Greece (Mathioudaki et al, 2018), Italy (Mandrone et al, 2017), Tunisia (Hosni et al, 2017), Serbia, Montenegro (Zdunic et al, 2017), Portugal (Nogueira et al, 2008), Lithuania (Bagdonaite et al, 2010), Jordan (AI-Rifaee et al, 2010), Iran (Pirbalouti et al, 2014), Peru (Ccana-Ccapatinta et al, 2014, and Turkey (Cirak et al, 2016a(Cirak et al, , 2016b(Cirak et al, , 2017a(Cirak et al, , 2017b have been investigated in respect to the presence of chemical ingredients that give health benefits.…”

Section: Introductionmentioning

confidence: 99%

Factors affecting the variation of bioactive compounds inHypericumspecies

Çırak

Radušienė

2019

Biologia Futura

View full text Add to dashboard Cite

The genus Hypericum (Hypericaceae) consists of 484 species from 36 sections with worldwide distribution in different areas. Turkey is considered as hot spot for diversity of Hypericum genus. Despite numerous publications, Hypericum species still attracted considerable scientific interest due to pharmaceutically relevant secondary metabolites: naphthodianthrones, acylphloroglucinol derivatives, phenolic acids, flavonoid glycosides, biflavonoids, and some other valuable constituents. Phytochemical investigations carried out on different Hypericum species provided highly heterogeneous results. The content of bioactive compounds varies significantly due to many internal and external factors, including plant organs, phenological stage, genetic profile, environmental abiotic and biotic factors, such as growing site, light, temperature, radiation, soil drought and salinity, pathogens, and herbivores attack. The variations in content of bioactive compounds in plants are regarded as the main problem in the standardization of Hypericum-derived pharmaceuticals and dietary supplements. The review discusses the main factors contributing to the variations of bioactive compounds and what kind of modulations can increase quality of Hypericum raw material.

show abstract

“…Most findings to date are associated with in vitro investigations in cell culture models such as keratinocytes, melanocytes, and fibroblast (Marques and MacNeil, 2016). Some studies have identified extracts from Hypericum species (H. androsaemum, H. brasiliense, H. canariense, H. grandifolium, H. reflexum, and H. sampsonii) as being interesting bioactive compounds with potent cytotoxic properties, mainly against melanoma cells of human origin (A375 and UACC-62 human malignant melanoma cell lines) (Caprioli et al, 2016;Chen et al, 2020;França et al, 2013;Zorzetto et al, 2015). The investigated cytotoxic compounds are mostly phloroglucinols (hyperforatin F, japonicin, uliginosin, and isouliginosin B) and anthraquinonoids (emodin).…”

Section: Cytotoxicity and Photodynamic Therapymentioning

confidence: 99%

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

Silva

Taofiq

Ferreira

et al. 2021

Industrial Crops and Products

View full text Add to dashboard Cite

Antiproliferative activity of the hexanic extract and phloroglucinols from Hypericum brasiliense

Cited by 6 publications

References 17 publications

Chemical Composition and New Biological Activities of Essential Oil and Hydrosol of Hypericum perforatum L. ssp. veronense (Schrank) H. Lindb

Chemical Composition and New Biological Activities of Essential Oil and Hydrosol of Hypericum perforatum L. ssp. veronense (Schrank) H. Lindb

Factors affecting the variation of bioactive compounds inHypericumspecies

Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties

Contact Info

Product

Resources

About