Evaluation of wound healing activity of Acacia leucophloea bark in rats

Suriyamoorthy, Sembian; Subramaniam, Kalidass; Karthikeyan, G.

doi:10.1590/s0102-695x2012005000121

Cited by 9 publications

(10 citation statements)

References 20 publications

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“…The percentage of contraction on the seventh day differed significantly from the CV group, however, with similar indexes to the positive control group (FIB). High contraction rates on the eighth day were also identified with the extract of the stem bark of Acacia leucopholea, Embelia ribes and Rumex abyssinicus [33,62,63].…”

Section: Discussionmentioning

confidence: 93%

Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice

et al. 2020

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Based on ethnopharmacological studies, a lot of plants, as well as its compounds, have been investigated for the potential use as wound healing agents. In Brazil, Curatella americana is traditionally used by local people to treat wounds, ulcers and inflammations. However, to the best of our knowledge, its traditional use in the treatment of wounds has not been validated by a scientific study. Here, some compounds, many of them flavonoids, were identified in the hydroethanolic extract from the leaves of C. americana (HECA) by LC-HRMS and LC-MS/MS. Besides that, solutions containing different concentrations of HECA and a gel produced with this extract were evaluated for its antimicrobial, coagulant and wound healing activities on an excision mouse wound model as well as its acute dermal safety. A total of thirteen compounds were identified in HECA, mainly quercetin, kaempferol and glucoside derivatives of both, besides catechin and epicatechin known as wound healing agents. The group treated with 1% of HECA exhibited highest wound healing activity and best rate of wound contraction confirmed by histopathology results. The present study provides scientific evidence of, this extract (HECA) possess remarkable wound healing activity, thereby, supporting the traditional use.

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Section: Discussionmentioning

confidence: 93%

Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice

et al. 2020

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“…Increased hexosamines levels in MZL-ointment treated group compared to controls displayed stabilization of collagen fibres by increasing electrostatic and ionic bonds with it (Murthy et al, 2013;Shetty, Udupa, & Udupa, 2008). Suriyamoorthy, Subramaniam, Wahab, and Karthikeyan (2012) reported that there is an increase in the levels of these components during the early stages of wound healing, following which normal levels are restored. Our findings on hexosamines are comparable to those described by these authors.…”

Section: Discussionmentioning

confidence: 96%

“…Suriyamoorthy, Subramaniam, Wahab, and Karthikeyan () reported that there is an increase in the levels of these components during the early stages of wound healing, following which normal levels are restored. Our findings on hexosamines are comparable to those described by these authors.…”

Section: Discussionmentioning

confidence: 99%

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In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

et al. 2018

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This study was performed to evaluate the wound healing potential and antioxidant effect of methanol extract of Zizyphus lotus leaves (MZL), and to identify its phenolic profile by HPLC‐PDA‐ESI‐MS. Wound healing activity was assessed in vivo using excision model. Biochemical and histopathological analyses were conducted. In vitro antioxidant potential of MZL was tested using 2,2‐diphenyl‐1‐picrylhydrazyl and β‐carotene bleaching methods. HPLC‐PDA‐ESI‐MS was used for the phenolic profiling. Animals treated with MZL ointment showed a significant reduction in epithelialization time and high contraction rate compared to controls. Proteins, hydroxyproline, and hexosamines contents of ointment‐treated animals were higher than controls. Marked cross‐linking of collagen fibers and lack of inflammatory cells were observed in the granulation tissue of the ointment‐treated animals. Chemical profiling of MZL revealed that quercetin‐3‐O‐rutinoside and catechin are the major constituents. Phenolic compounds of the methanol extract of Zizyphus lotus leaves may be engaged in the acceleration of the healing process activity. Practical application In Mediterranean region, like Algeria, Zizyphus lotus is used in nutrition, health, and cosmetics. Several parts of this plant are employed to treat urinary troubles, diabetes, skin infections, fever, diarrhea, insomnia, bronchitis, and hypoglycemia. There is no scientific paper investigating the phenolic composition of Z. lotus leaves using a mass spectrometry coupled high‐performance liquid chromatography, as well as examining their wound healing potential. Results from this study revealed the presence of many flavonoids exhibiting important antioxidant and wound healing potentials through specific mechanisms. Z. lotus leaves are a source of pharmacologically active compounds with benefits for human nutrition, health‐promoting, and disease preventing.

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“…This plant species is used to make chemical products, fiber, food (human and animal), drink (human and animal), medicine, and used for wood (Global Biodiversity Information Facility 2021; Kew Science 2021; Khare 2007). This plant species has been applied to heal including bleedings, bronchitis, constipation, cough, dental cavity, diabetes, diarrhea, dysentery, fevers, gingivitis, high cholesterol, indigestion, leprosy, nausea, snakebite, sore throat, and wounds (Bhadoria and Gupta 1981;Khare 2007;Sathasivampillai et al 2017Sathasivampillai et al , 2018Sathasivampillai et al , 2016Sathasivampillai et al , 2015Suriyamoorthy et al 2012). Phytochemicals including betulinic acid-3-O-β-d-maltoside; linoleic acid; oleic acid; γtocopherol; β-tocopherol; β-sitosterol; Δ 7 -avenasterol; myricetin; quercetin; leucophleol; leucophleoxol; leucoxol; catechin; O-methyl epicatechin; gallic acid; leuco-fisetinidin; ferulic acid; and syringic acid have been isolated from bark, root, and leaf of V. leucophloea (Del Carmen Apreda Rojas et al 2001;Mishra and Srivastava 1985;Saxena and Srivastava 1986;Sulaiman et al 2016;Valsakumari and Sulochana 1991;Zia-Ul-Haq et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of extracts and isolated compounds of Vachellia leucophloea (Roxb.) Maslin, Seigler & Ebinger

Sathasivampillai¹,

Sebastian

2021

Bulletin of Biotechnology

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Vachellia leucophloea (Roxb.) Maslin, Seigler & Ebinger is a tree that fits into the Fabaceae family. V. leucophloea has been applied to heal including bronchitis, diabetes, high cholesterol, leprosy, and snakebite. Phytochemicals including betulinic acid-3-O-β-d-maltoside; Δ 7avenasterol; leucophleol; leucophleoxol; and leucoxol; have been isolated from bark, root, and leaf of this plant species. This systematic review article purposes to evaluate, outline, and document the bioactivities associated with available researches involving V. leucophloea. PubMed, Semantic Scholar, Scopus, ScienceDirect, and Web of Science electronic records were employed to find the applicable available works from 1900 to June 2021. So far, in vivo and in vitro scientific evidence is presently existing for several bioactivities. To date, antidiabetic, antidiarrheal, antihyperlipidemic, antipyretic, wound healing, antibacterial, antidementia, antifungal, antiinflammatory, antioxidant, antiplatelet, and bronchorelaxant activities have been scientifically demonstrated for different parts of this plant species. Only an antidiabetic compound {(-)-Fisetinidol-(4α,8)-[(-)-fisetinidol-(4α,6)]-(+)-catechin} has been isolated from this plant species. Further in vitro, in vivo, and clinical studies of various traditional medicinal uses of V. leucophloea should be investigated as well as the bioactive compounds should be identified.

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Evaluation of wound healing activity of Acacia leucophloea bark in rats

Cited by 9 publications

References 20 publications

Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice

Chemical profiling of Curatella americana Linn leaves by UPLC-HRMS and its wound healing activity in mice

In vivo wound healing potential and HPLC-PDA-ESI-MS profiling ofZizyphus lotusL. (Desf.) leaves methanol extract

Bioactivities of extracts and isolated compounds of Vachellia leucophloea (Roxb.) Maslin, Seigler & Ebinger

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