Clerodendron glandulosum Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats

Abstract

RESUMO: "Clerodendron glandulosum Coleb., Verbenaceae, melhora a dieta rica em gordura induzida por alteração no metabolismo de lipídios e colesterol em ratos." Este estudo foi realizado para avaliar a eficácia do extrato liofilizado das folhas de Clerodendron glandulosum Coleb., Verbenaceae (FECG), em alterar o metabolismo de lipídios e colesterol em ratos hiperlipidêmicos alimentados em uma dieta rica em gordura. Plasma e perfil lipídico hepático, lipídeos e enzimas que metabolizam o colesterol em tecidos-alvo e o conteúdo de lipídeos fecais totais e ácidos biliares foram avaliados em ratos normolipidêmicos e hiperlipidêmicos tratados com FECG. Os resultados foram comparados com a droga sintética hipolipemiante Lovastatina (LVS). Os resultados indicam que FECG foi capaz de regular positivamente a hiperlipidemia induzida experimentalmente por alteração significativa no perfil lipídico do plasma e tecidos. Estes resultados podem ser atribuídos à absorção reduzida, a eliminação efetiva e catabolismo aumentado de lipídeos e colesterol, possivelmente devido ao alto teor de saponina e fitoesteróis em C. glandulosum Coleb. Uso de extrato de C. glandulosum como um possível agente terapêutico contra a hipercolesterolemia e hipertrigliceridemia é indicado. Unitermos:Clerodendron glandulosum, Verbenaceae, hiperlipidemia, hipercolesterolemia. ABSTRACT:The present study was undertaken to evaluate the efficacy of freeze dried extract of Clerodendron glandulosum Coleb., Verbenaceae, leaves (FECG) on alteration in lipid and cholesterol metabolism in high fat diet fed hyperlipidemic rats. Plasma and hepatic lipid profiles, lipid and cholesterol metabolizing enzymes in target tissues and fecal total lipids and bile acid contents were evaluated in FECG treated normolipidemic and hyperlipidemic rats. These results were compared with synthetic hypolipidemic drug Lovastatin (LVS). Results indicate that FECG was able to positively regulate induced experimental hyperlipidemia by significant alteration in plasma and tissue lipid profiles. These results can be attributed to reduced absorption, effective elimination and augmented catabolism of lipids and cholesterol possibly due to high content of saponin and phytosterols in C. glandulosum. Use of C. glandulosum extract as a potential therapeutic agent against hypercholesterolemia and hypertriglyceridemia is indicated.

Anti-obesity potential of Clerodendron glandulosum.Coleb leaf aqueous extract

“…These results are in tune with a previous study from our laboratory reporting reduced absorption of lipids through intestine and excretion of the same through faeces in CG treated hyperlipidemic rats (Jadeja et al, 2010b). In addition, HFD fed OB mice recorded significant increment in size and mass of abdominal, renal and epididymal fat pads while, this increment was prevented in CG supplemented OB mice.…”

“…Traditionally, cross sections of people across Manipur consume decoction of CG leaves for treating diabetes, obesity and hypertension (Jadeja et al, 2009). Recent studies from our laboratory have shown that, CG aqueous extract can improve fructose induced insulin resistance and hypertension (Jadeja et al, 2010a), regulate high fat diet induced hyperlipidemia in rats (Jadeja et al, 2010b) and prevent HFD induced hepatic steatosis (Jadeja et al, 2010c). In addition, safety evaluation of CG aqueous extract in Swiss albino mice has revealed its LD 50 indices to be higher than 3000 mg/kg (Jadeja et al, 2011).…”

Anthocyanin‐rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet

“…In the present study, ARCE‐treated rats fed the ATH diet recorded a significant decrement in the tissue lipid load in cardiac and hepatic tissue and a higher elimination of TC and TG through faeces. Previous studies have reported that herbal extracts are capable of increasing elimination of dietary TC and TG through faeces primarily by inhibiting its intestinal absorption 17. Hence, it can be presumed that hypolipidaemic and hypocholesterolaemic properties of ARCE are possibly due to its ability to hamper absorption of TC and TG in the intestine and this possibility needs further scrutiny.…”

Antiobesity Effect ofCodonopsis lanceolatain High-Calorie/High-Fat-Diet-Induced Obese Rats

“…A good example of this is Clerodendron glandulosum Coleb. This herb, found in north eastern states of India [1], is a folklore medicine consumed by urban and tribal populace of Manipur against obesity, diabetes, and hypertension [2, 3]. Recently, it has been reported that aqueous extracts from Clerodendron glandulosum Coleb.…”

“…Recently, it has been reported that aqueous extracts from Clerodendron glandulosum Coleb. can regulate high-fat-diet induced hyperlipidemia in rats [3], improve fructose induced insulin resistance and hypertension [4], and prevent high-fat-diet-induced hepatic steatosis [5]. …”