Anthocyanin‐rich red cabbage (<i>Brassica oleracea</i> L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet

Sankhari, Jayanta M; Thounaojam, Menaka C.; Jadeja, Ravirajsinh N.; Devkar, Ranjitsinh V.; Ramachandran, A. V.

doi:10.1002/jsfa.5532

Cited by 75 publications

(43 citation statements)

References 30 publications

(32 reference statements)

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“…These findings suggest that the RCE might possess the ability to reduce reactive oxygen free radicals and improve the activities of hepatic antioxidant enzymes. The present findings are in accordance with a recent study in which the red cabbage methanolic extract has been shown to possess a protective role against atherogenic diet-induced hepatic injury in rats (Sankhari et al, 2012).…”

Section: Discussionsupporting

confidence: 94%

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

Al‐Dosari

2014

Am. J. Chin. Med.

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The widely used culinary vegetable, red cabbage (Brassica oleracea L. Var. capitata f. rubra), of the Brassicaceae family contains biologically potent anthocyanins and a myriad of antioxidants. Previous studies have shown that the pharmacological effects of red cabbage in vivo are redox-sensitive. The present study explored whether red cabbage modulates various histopathological and biochemical parameters in rats administered with a cholesterol-rich diet (CRD). To this end, prolonged administration of a lyophilized-aqueous extract of red cabbage (250 and 500 mg/kg body weight) significantly blunted the imbalances in lipids, liver enzymes and renal osmolytes induced by the CRD. The effects of red cabbage were compared to simvastatin (30 mg/kg body weight) treated rats. Estimation of malondialdehyde and non-protein sulfhydryls revealed robust antioxidant properties of red cabbage. Histopathological analysis of livers from rats administered with red cabbage showed marked inhibition in inflammatory and necrotic changes triggered by CRD. Similarly, in vitro studies using a 2',7'-Dichlorofluorescein-based assay showed that red cabbage conferred cytoprotective effects in cultured HepG2 cells. In conclusion, the present study discloses the potential therapeutic effects of red cabbage in dyslipidemia as well as hepatic injury, that is at least, partly mediated by its antioxidant properties.

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Section: Discussionsupporting

confidence: 94%

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

Al‐Dosari

2014

Am. J. Chin. Med.

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“…capitata rubra ) is known for its protective role against cardiac and hepatic oxidative stress in rats fed an atherogenic diet [4], hypocholesterolemic activity in tumour-bearing mice [5], neuroprotective activity in N-methyl-D-aspartate-treated rats [6, 7], paraquat-induced oxidative stress in rats [8], nephroprotective activity in diabetic rats [9], and hepatoprotective activity in carbon tetrachloride-treated rats [10]. Moreover, in vitro polyphenol extract from red cabbage influenced properties of erythrocyte membrane with high concentration of cholesterol [11] and demonstrated high antioxidant activity [12–17].…”

Section: Introductionmentioning

confidence: 99%

Matrix Effects on the Stability and Antioxidant Activity of Red Cabbage Anthocyanins under Simulated Gastrointestinal Digestion

Podsędek

Redzynia

Klewicka

et al. 2014

BioMed Research International

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Red cabbage is, among different vegetables, one of the major sources of anthocyanins. In the present study an in vitro digestion method has been used to assay the influence of the physiological conditions in the stomach and small intestine, as well as faecal microflora on anthocyanins stability in red cabbage and anthocyanin-rich extract. The recovery of anthocyanins during in vitro gastrointestinal digestion was strongly influenced by food matrix. The results showed that other constituents present in cabbage enhanced the stability of anthocyanins during the digestion. The amount of anthocyanins (HPLC method) and antioxidant capacity (ABTS and FRAP assays) strongly decreased after pancreatic-bile digestion in both matrices but total phenolics content (Folin-Ciocalteu assay) in these digestions was higher than in initial samples. Incubation with human faecal microflora caused further decline in anthocyanins content. The results obtained suggest that intact anthocyanins in gastric and products of their decomposition in small and large intestine may be mainly responsible for the antioxidant activity and other physiological effects after consumption of red cabbage.

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“…28 This is reported to have anti-oxidant, anti-microbial, gastroprotective, anti-cancer, anti-diabetic, cardioprotective and hepatoprotective effects. [29][30][31][32][33][34][35] Broccoli (Brassica oleracea) contains phenolic compounds and has marked antioxidant activity has been selected and evaluated for its anxiolytic potential. This plant has never been evaluated for their antianxiety potential, therefore it was investigated for its anxiolytic potential.…”

Section: Physicochemical Evaluationmentioning

confidence: 99%

Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals

Kaur¹,

Shri²,

Kamboj³

2017

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Introduction:Oxidative stress in the brain causes nervous system impairment. Hence the use of antioxidants could be an effective approach to prevent disorders such as anxiety. Plants containing phenolic constituents are reported to be potent antioxidants. Brassica oleracea L. commonly known as broccoli, is rich in phenolics mainly flavonoids and possesses excellent antioxidant property, however its anxiolytic potential has not been investigated. Thus in the present study antianxiety activity of extracts of broccoli was evaluated in experimental animals. Materials and Methods: Various pharmacognostic parameters of the plant material were studied following standard procedures. Groups of six mice each were taken as different treatment groups. Control group received vehicle (1% Carboxy Methyl Cellulose), positive control received Diazepam (2mg/kg) as standard drug while test groups received petroleum ether and hydroalcoholic extracts (50, 100 and 200 mg/kg body weight, p.o.). The effects were evaluated on Elevated Plus Maze (EPM), hole board and mirror chamber tests. Statistical analysis was performed using ANOVA, followed by Turkey's post-hoc test. Results: Hydroalcoholic extract shows dose dependent increase in the average time spent and frequency of entries in the open arms of the EPM; decreased latency, increased time spent and frequency of entries in the mirror chamber; increased number of head dips in hole board test as compared to control was observed. These effects were comparable to the effect produced by diazepam. Phytochemical screening of the bioactive extract revealed the presence of alkaloids, phenols, flavonoids and tannins. Conclusion: From our study, it can be concluded that hydroalcoholic extract of Brassica oleracea at the dose of 200 mg/kg possesses marked anxiolytic activity.

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Anthocyanin‐rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet

Abstract: Thus, the present study provides the first scientific evidence for a protective role of ARCE against ATH diet-induced hypercholesterolaemia and cardiac and hepatic oxidative stress.

Cited by 75 publications

References 30 publications

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

Red Cabbage (Brassica oleraceaL.) Mediates Redox-Sensitive Amelioration of Dyslipidemia and Hepatic Injury Induced by Exogenous Cholesterol Administration

Matrix Effects on the Stability and Antioxidant Activity of Red Cabbage Anthocyanins under Simulated Gastrointestinal Digestion

Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals

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