The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer

Kalil, Antônio Nocchi; Coral, Gabriela Perdomo; Santos, Félix Antônio Insaurriaga dos; Gonzalez, Maria Cristina; Neutzling, Cristiane Becker

doi:10.1590/s0102-67202014000200008

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…Resection appears today as the main approach for treatment of HCC, especially in patients with good liver function. This mainly occurs because of the restrictive criteria and the inadequate supply of grafts for transplantation in the world 1 , 11 , 13 , 16 , 19 .…”

Section: Discussionmentioning

confidence: 99%

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Lopes

Coelho

Krüger

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and its incidence is increasing around the world in the last decades, making it the third cause of death by cancer in the world. Hepatic resection is one of the most effective treatments for HCC with five-year survival rates from 50-70%, especially for patients with a single nodule and preserved liver function. Some studies have shown a worse prognosis for HCC patients whose etiology is viral. That brings us to the question about the existence of a difference between the various causes of HCC and its prognosis. Aim: To compare the prognosis (overall and disease-free survival at five years) of patients undergoing hepatectomy for the treatment of HCC with respect to various causes of liver disease. Method: Was performed a review of medical records of patients undergoing hepatectomy between 2000 and 2014 for the treatment of HCC. They were divided into groups according to the cause of liver disease, followed by overall and disease-free survival analysis for comparison. Results:There was no statistically significant difference in the outcomes of the groups of patients divided according to the etiology of HCC. Overall and disease-free survival at five years of the patients in this sample were 49.9% and 40.7%, respectively. Conclusion: From the data of this sample, was verified that there was no prognostic differences among the groups of HCC patients of the various etiologies.

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Section: Discussionmentioning

confidence: 99%

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Lopes

Coelho

Krüger

et al. 2016

ABCD, arq. bras. cir. dig.

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“…Many of used therapeutic procedures, such as live donor transplant and hepatic tumor resection, depend on hepatic regeneration to increase functional capacity of the liver. Given this knowledge, different studies have been performed 6 , 9 , 12 , 17 , 19 .…”

Section: Introductionmentioning

confidence: 99%

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Sobral

Daga

Rasera

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. Method: 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. Results: The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Conclusion: Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.

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“…Hepatic steatosis is the most common form of response to liver cell damage (Kalil et al 2014). The 5-fluorouracil, platinum derivatives and taxanes of the chemotherapy drugs are known to lead to hepatic steatosis in human medicine (Sharma et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic imaging of a mass-shape hepatic steatosis in a dog treated with chemotherapy

Lee¹,

JeongHyun²,

Kim³

et al. 2020

Vet. Med. - Czech

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A left medial liver mass was found through the monitoring of the metastasis in a 15-years-old, spayed female Maltese dog. The patient had a history of chemotherapy with carboplatin after surgical resection of the mammary gland tumour. Ultrasonography (US) showed a massive hyperechoic mass in the left liver. The left medial liver mass was identified as a poorly demarcated, hypoattenuated area on the non-enhanced and all the phases of contrast-enhanced computed tomography. The liver mass was surgically removed and the histopathological examination showed a fatty deposition and no evidence of neoplasm. Based on the patient’s history, diagnostic imaging and histopathological findings, the liver mass was considered as a chemotherapy-induced hepatic steatosis. This report provides the diagnostic imaging characteristics of the hepatic steatosis that could help differentiate it from a malignancy in a dog treated with chemotherapy.

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The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer

Cited by 8 publications

References 29 publications

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Influence of Hepatocellular Carcinoma Etiology in the Survival After Resection

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Diagnostic imaging of a mass-shape hepatic steatosis in a dog treated with chemotherapy

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