Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Abstract

Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. Method: 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. Results: The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Conclusion: Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.

Functional and Cellular Evaluation of the Liver After Low-Power Laser Stimulation During Surgery

“…The studies performed by Araujo Lima et al 2 and Monteiro 17 , both with hepatectomized cirrhotic Wistar rats, demonstrated that liver function tests remain within normal limits. In this study, all groups presented mean AST values, lower than the reference values ​​in the literature (39-92 U/l) 27 , but were not statistically significant when compared to each other. There was a decrease in ALT in the 14-day control group, already mentioned by other authors 20 .…”

“…Collagen is a protein derived from the extracellular matrix, and can perform various functions in the body 14 . In the liver, when an injury occurs, at the first moment there is irregular deposition of collagen, which tends to decrease as the liver tissue regenerates 27 . However, when there is a very extensive and permanent lesion, the process of reducing collagen excess does not occur and there is no architectural division, forming fibrotic areas that can be stimulated by infectious processes or by overexposure of the liver to potentially irreversible toxic substances, considered cirrhosis .…”

Use of Tranexamic Acid in Trauma Patients: An Analysis of Cost-Effectiveness for Use in Brazil

“…Randomized controlled trials, cohort studies and meta-analyzes were performed to evaluate and measure the potential effects of TXA utilization in trauma patients 3 , 5 , 20 , 23 .…”

Uso Do Ácido Tranexâmico Em Ressuscitação Traumática No Ambiente Pré-Hospitalr: Relato De Caso

“…Ensaios clínicos randomizados, coortes e metanálises têm sido realizados a fim de avaliar o custo efetividade do uso do TXA no atendimento inicial ao trauma na condição de choque hemorrágico (COATS et al, 2011;CRASH-2, 2011;ROBERTS et al, 2012;SOBRAL, 2016), entretanto pouco tem sido estudado sobre o manejo dessa medicação na realidade brasileira (GUERRIERO, 2011).…”