Sobrevida em pacientes com câncer gástrico em Campinas, São Paulo, Brasil

Bustamante-Teixeira, Maria Teresa; Faerstein, Eduardo; Mariotto, Angela B.; Britto, Anna Valéria de; Filho, Djalma de Carvalho Moreira; Latorre, Maria do Rosário Dias de Oliveira

doi:10.1590/s0102-311x2006000800009

Cited by 7 publications

(6 citation statements)

References 12 publications

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“…The mortality due to GC has been decreasing worldwide, including in Latin America (230,231) . In Brazil, despite a mild decrease, mortality is high, and the survival rate during the first year of disease is estimated at 32% and decreases to 9% at the end of 5 years (232)(233)(234) .…”

Section: Level Of Evidence: 2cmentioning

confidence: 99%

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Coelho

Marinho

Genta

et al. 2018

Arq. Gastroenterol.

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Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting. The participants were invited based on their knowledge and contribution to the study of H. pylori infection. The meeting sought to review different aspects of treatment for infection; establish a correlation between infection, dyspepsia, intestinal microbiota changes, and other disorders with a special emphasis on gastric cancer; and reassess the epidemiological and diagnostic aspects of H. pylori infection. Participants were allocated into four groups as follows: 1) Epidemiology and Diagnosis, 2) Dyspepsia, intestinal microbiota and other afections, 3) Gastric Cancer, and, 4) Treatment. Before the consensus meeting, participants received a topic to be discussed and prepared a document containing a recent literature review and statements that should be discussed and eventually modified during the face-to-face meeting. All statements were evaluated in two rounds of voting. Initially, each participant discussed the document and statements with his group for possible modifications and voting. Subsequently, during a second voting in a plenary session in the presence of all participants, the statements were voted upon and eventually modified. The participants could vote using five alternatives: 1) strongly agree; 2) partially agree; 3) undecided; 4) disagree; and 5) strongly disagree. The adopted consensus index was that 80% of the participants responded that they strongly or partially agreed with each statement. The recommendations reported are intended to provide the most current and relevant evidences to management of H. pylori infection in adult population in Brazil.

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Section: Level Of Evidence: 2cmentioning

confidence: 99%

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Coelho

Marinho

Genta

et al. 2018

Arq. Gastroenterol.

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“…European data shows that only 21% of patients survive more than five years after diagnosis (7) . And therefore, in Brazil and in the world, it is a major public health problem.…”

Section: Genotype Association Gstm1 Null and Gastric Cancer: Evidencementioning

confidence: 99%

Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Ribeiro

Nascimento

Silva

2017

Arq. Gastroenterol.

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-Background -Gastric cancer is the fourth most common cancer in men and the sixth among women, except for non-melanoma skin tumors, in Brazil. Epidemiological evidences reveal the multifactorial etiology of this cancer, highlighting risk factors such as: infection by the bacterium Helicobacter pylori, advanced age, smoking, chronic alcohol abuse, eating habits and genetic polymorphisms. Considering the context of genetic polymorphisms, there is the absence of the GSTM1 gene. The lack of GSTM1 function to detoxify xenobiotics and promote defense against oxidative stress leads to increased DNA damage, promoting gastric carcinogenesis. This process is multifactorial and the development of gastric cancer results from a complex interaction of these variables. Objective -The aim of this study was to investigate the association of GSTM1 null polymorphism in the pathogenesis of gastric cancer. Methods -A meta-analysis was conducted from 70 articles collected in SciELO and PubMed databases, between September 2015 and July 2016. In order to evaluate a possible association, we used the odds ratio (OR) and confidence interval of 95% (CI 95%). To assess the heterogeneity of the studies was used the chi-square test. Statistical analysis was performed using the BioEstat ® 5.3. Results -This study included 70 studies of case-control, including 28,549 individuals, which were assessed for the null polymorphism of the GSTM1 gene, and of which 11,208 (39.26%) were cases and 17,341 (60.74%) were controls. The final analysis showed that the presence of the GSTM1 gene acts as a protective factor against the development of gastric cancer (OR=0.788; 95%CI 0.725-0.857; P<0.0001). Positive statistical association was found in Asia (OR=0.736; P<0.0001) and Eurasia (OR=0.671; P=0.05). However, statistically significant data was not obtained in Europe (OR=1.033; 95%CI 0.873-1.222; P=0.705) and America (OR=0.866; 95%CI 0.549-1.364; P=0.534). Therefore, the results can not be deduced around the world. Conclusion -This meta-analysis concluded that the presence of the GSTM1 gene is a protector for the emergence of gastric cancer, especially in Asian countries, but this result was not found in Europe and America.

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“…Researchers believe that mortality and morbidity rates of gastric cancer is high even after early detection of the disease because of high costs of treatment. 6 According to the study of Biglarian et al 7 the mortality from gastric cancer in Iran has increased in recent years. According to the researches, the increase in the incidence and changes in the pattern of the disease (mostly involving proximal parts of the stomach compared to distal parts) are the main reasons for the increase in mortality from this disease.…”

mentioning

confidence: 99%

“…According to the findings of other studies, later seeking for medical care could result in diagnosis of disease in higher stages which contributes to increased mortality rates in these patients. 6,8 Health care providers should pay more attention to early diagnosis of patients to reduce their mortality rate.…”

mentioning

confidence: 99%

Effective factors on 3-year mortality of operated gastric cancer at Modarres Hospital during 5 years

Gholizade¹,

Malekpour²

2017

J Anal Res Clin Med

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Gastric cancer is one of most common and fatal malignancies worldwide. Majority of patients have advanced stage when visiting the physician. The aim of this study was to investigate the associated factors with mortality of operated gastric cancer at Modarres Hospital, Tehran, Iran. All patients with gastric cancer that referred to Modarres Hospital between 2011 and 2016 were included in this study and data were gathered through patients' medical records and telephone interviews. Analysis was done by SPSS software. In this study 73 patients with gastric cancer participated. Three-years mortality was 72.1%. There was a significant association between the stage of cancer and mortality rate. Although mortality reduced by using neoadjuvant therapy. High mortality of patients with gastric cancer in this study was directly related to higher stage of cancer and lack of a neoadjuvant therapy.

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Sobrevida em pacientes com câncer gástrico em Campinas, São Paulo, Brasil

Cited by 7 publications

References 12 publications

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Genotype Association Gstm1 Null and Gastric Cancer: Evidence-Based Meta-Analysis

Effective factors on 3-year mortality of operated gastric cancer at Modarres Hospital during 5 years

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