Triagem de hemoglobinopatias em doadores de sangue de Caxias do Sul, Rio Grande do Sul, Brasil: prevalência em área de colonização italiana

Lisot, Cristina Lucia Alberti; Silla, Lúcia Mariano da Rocha

doi:10.1590/s0102-311x2004000600017

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…However, researchers recommend caution when diagnosing beta thalassemia only by the dosage of Hb A2. They point out that elevated levels can also be detected in other acquired and congenital conditions and suggest repeating the test before arriving at any diagnostic conclusion ( 7 , 29 ) . Thus, we recommend further studies to confirm these findings.…”

Section: Discussionmentioning

confidence: 99%

Etiology of anemia of blood donor candidates deferred by hematologic screening

Silva¹,

Souza²,

Carlos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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Objective: Iron deficiency is the most common cause of anemia and one of the main factors in the clinical deferral of blood donors. This fact prompted the current study that aimed to determine the prevalence and etiology of anemia in blood donor candidates and to evaluate the hematological screening technique used for the exclusion of these donors. Methods: This was a prospective study that compared two groups (Anemic and Non-anemic). Initially screening for anemia was performed by manually measuring hemoglobin (Bioclin® Kit); the results were subsequently compared with an automated screening method (Coulter T-890). The etiology was investigated by hemoglobin electrophoresis in alkaline and acid pH, Hb A2 dosage and measurement of the ferritin concentration by immunoagglutination. Differences and associations of interest were analyzed using the Yates and McNemar's Chi-square tests and the Fisher, Mann-Whitney, Wilcoxon and Kruskal-Wallis tests. Results: The deferral rate due to anemia was 4.2%; iron deficiency was identified in 37.5% and beta thalassemia in 9.3% of the excluded candidates. There was a significant discrepancy between the two techniques used to measure hemoglobin with 38.1% of initially deferred donors presenting normal hemoglobin levels by the automated method. Conclusion: The results show a high rate of blood donors being deferred for anemia and confirm that iron deficiency is the most prevalent cause. The discrepancies found by comparing screening methods suggest that hemoglobin and hematocrit levels should be confirmed before deferring a donor due to anemia; this may increase supplies in blood banks.

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Section: Discussionmentioning

confidence: 99%

Etiology of anemia of blood donor candidates deferred by hematologic screening

Silva¹,

Souza²,

Carlos³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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“…In countries with a high prevalence of the sickle cell trait (SCT), which is often determined by neonatal screening programs, a significant proportion of blood donors may be SCT carriers [1]. In Brazil, for example, where SCT prevalence ranges from 1.1% to 9.8% in the overall population [2], the trait is found in up to 2.48% of blood donors [3][4][5][6][7]. Because individuals with SCT are usually asymptomatic, many of them are unaware of their condition at the time of donation [1].…”

Section: Introductionmentioning

confidence: 99%

A new insight into apheresis platelet donation by sickle cell trait carriers: evidences of safety and quality

Barbosa¹,

Brunetta²,

Filho³

et al. 2019

Hematol Med Oncol

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Patient socioeconomic status as a prognostic factor for allo-SCT

Silla

Fischer

Paz

et al. 2008

Bone Marrow Transplant

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The aim of the present study was to assess the influence of socioeconomic status (SeS) on the outcome of allo-SCT at a Brazilian SCT center. In total, 201 patients receiving HLA-identical related allo-SCTs were studied. The median age was 30 years. Overall, 163 patients had malignancies (CML 68, ALL/AML 63, myelodysplastic syndrome 12 and others 20). SeS was defined according to the Brazilian Association of Market Research Agencies classification, where people are clustered in groups A-E (richest to poorest). In total, 146 patients (72%) were classified as richest (A+B+C) and 55 (28%) as poorest (D+E). The D+E SeS group was associated with a higher incidence of chronic GVHD and acute GVHD (hazard ratio (HR)=2.61; P=0.001 and HR=2.62; P=0.001, respectively), better platelet and neutrophil engraftment (HR=1.94; P=<0.001 and HR=2.12; P=0.001) and with a higher TRM in multivariate analysis (HR=1.92; P=0.039). Estimated overall survival at 5 years was 55.2%. A D+E SeS (HR=2.13; P=0.001) was associated with a worse survival on multivariate analysis. In conclusion, a lower SeS is a strong prognostic factor in patients undergoing allo-SCT in Brazil, influencing engraftment, TRM and overall survival.

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Triagem de hemoglobinopatias em doadores de sangue de Caxias do Sul, Rio Grande do Sul, Brasil: prevalência em área de colonização italiana

Cited by 9 publications

References 17 publications

Etiology of anemia of blood donor candidates deferred by hematologic screening

Etiology of anemia of blood donor candidates deferred by hematologic screening

A new insight into apheresis platelet donation by sickle cell trait carriers: evidences of safety and quality

Patient socioeconomic status as a prognostic factor for allo-SCT

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