Polymorphisms of the coding region of Slc11a1 (Nramp1) gene associated to natural resistance against bovine brucellosis

Paixão, Tatiane Alves da; Martínez, Rodrigo; Santos, Renato L.

doi:10.1590/s0102-09352012000400041

Cited by 7 publications

(5 citation statements)

References 12 publications

(9 reference statements)

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“…It was observed that naturally infected susceptible cows were often homozygous for the polymorphism, exhibiting the CC genotype in SPN4, and AA in SPN5. These results can support genetic selection of resistant animals (Paixão, Martinez & Santos 2012).…”

Section: Brucellosissupporting

confidence: 55%

“…The gene encodes a transmembrane transporter located in the phagolysosome, which contributes to the bactericidal activity of macrophages. In cattle, natural resistance to B. abortus is associated with polymorphisms in the microsatellite 3'untranslated region (3'UTR) of the Slc11a1 gene, but the association between this polymorphism and natural infection remains controversial (Paixão, Martinez & Santos 2012). Martínez et al (2008) studied three polymorphisms in the gene Slc11a1 (SNP4, 5, and 6).…”

Section: Brucellosismentioning

confidence: 99%

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Resistencia y resiliencia a las enfermedades en las razas de rumiantes locales: un enfoque en América del Sur

et al. 2020

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La pérdida de variabilidad genética de interés ha tomado importancia no sólo la producción, sino también porque puede tener un efecto negativo en la epidemiología de las enfermedades animales. La actividad ganadera puede presentar considerables pérdidas económicas periódicas debido a la eliminación de animales, la reducción de la productividad, la falta de expresión del potencial genético de los animales, los costes de tratamiento, la asistencia laboral y profesional, el cierre del comercio debido a los obstáculos sanitarios y la competencia con los mercados extranjeros. Por lo tanto, la resistencia a las enfermedades es un atributo deseado en la producción ganadera y la salud animal puede estar limitando en los sistemas de producción de ganado. Existe cierta confusión en la terminología: la resistencia se define como la capacidad del huésped para ejercer cierto grado de control sobre el ciclo de vida del patógeno, mientras que la tolerancia define el impacto de la infección en el rendimiento animal. Un concepto muy cercano a la tolerancia es la resiliencia, que se puede definir como mantener la capacidad productiva del animal frente a la infección. Existen numerosos informes que indican las razas locales como un importante reservorio de resistencia genética natural a las enfermedades como un proceso de adaptabilidad al medio ambiente. Refiriéndose a las principales enfermedades de los animales domésticos (tuberculosis, brucelosis, fiebre aftosa, etc.), numerosos genes han sido identificados y estudiados como biomarcadores de resistencia y tolerancia como los genes BOLA, CD, NOD y SLC11A1 entre los más importantes. Aunque el factor limitante para que los programas de reproducción incluyan resistencia a enfermedades genéticas es la necesidad de cuantificar los fenotipos de resistencia. Esto puede ser costoso y logísticamente difícil, y es una barrera significativa para la selección de la resistencia a las enfermedades. Por esta razón, las características de resistencia a la enfermedad son un objetivo atractivo para los estudios genómicos y generalmente son objeto de estos estudios.

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Section: Brucellosissupporting

confidence: 55%

Section: Brucellosismentioning

confidence: 99%

Resistencia y resiliencia a las enfermedades en las razas de rumiantes locales: un enfoque en América del Sur

et al. 2020

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“…Importantly, some evidence suggests that peripheral blood leukocytes from Zebu may respond differently than cells from European breeds when stimulated (Turni et al, 2002). Furthermore, clear differences have been observed in the frequency of alleles of Nramp1, a gene that has been linked to natural resistance to intracellular pathogens (Paixão et al, 2006(Paixão et al, , 2012. Susceptibility to infection is partially determined by genetic or physical characteristics (O'Kelly and Spiers, 1976), but it is also related to the profile and pattern of immune response of the animal.…”

Section: Discussionmentioning

confidence: 99%

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

Macêdo

Marciano²,

Rocha³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Differences in cellular and humoral immunity in Zebu (Bos taurus indicus) and European (B. taurus taurus) cattle breeds, which may be related to differences in resistance or susceptibility to infectious or parasitic diseases, are largely unknown. This study aimed to perform a comparative analysis of innate and adaptive immunity of European (including Holstein, Brown Swiss, and Hereford) and Zebu (including Gir, Nelore, and Guzera) breeds, by assessing their peripheral blood leukocyte profiles (i.e., monocytes, eosinophils, and lymphocytes, including CD4 + and CD8 + T cells, and CD21 + B cells). Phenotypic profile of peripheral blood bovine leukocytesHigher frequencies of cells involved in innate immunity were observed in Zebu breeds, particularly monocytes and non-T and non-B cells (13.37 ± 0.9058 and 37.67 ± 1.55, respectively). This finding may contribute to the increased resistance of B. taurus indicus to certain infectious and parasitic diseases. Considering other leukocyte populations in the peripheral blood, among-breed variation was greater than differences between the two subspecies. This study will serve as a basis for further investigations regarding comparative immunology and resistance to infectious and parasitic diseases of cattle.

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“…Kumar et al (2011) reported no association of g. 221K and g.642R with Brucellosis resistance trait in cattle. However, many previous studies reported that bovine Tuberculosis resistance can be associated by many SNP's of NRAMP1 gene at 3'UTR (Kadarmideen et al, 2011); exon 4, intron 4 (Cheng et al, 2015); exon 9, exon 11 (Baqir et al, 2016), intron 9, intron 12 (Liu et al, 2016), exon 10 and exon 11 (Paixao et al, 2012) regions. Nonetheless, Joo et al (2003) reported monomorphism in the exon 5 of NRAMP gene in healthy and infected Mastitis cows.…”

Section: Discussionmentioning

confidence: 99%

NRAMP1 Gene Polymorphism: A Pathogenic Bacterial Resistance Trait in Indonesia Cattle

Hartati

2023

PAKJAS

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The pathogenic bacterial infection is the main cause of decreased cow productivity. This study aimed to investigate the relationship of Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms with pathogenic bacterial resistance traits in Indonesian cattle. A total of seventeen (17) animals of mixed-breed cattle comprising two categories healthy (7 heads) and infected with bacteria (10 heads) were used in this study. Forward sequencing analysis was performed to detect single nucleotide polymorphisms (SNPs) in the partial NRAMP1 gene (954 bp) using polymerase chain reaction (PCR). Results showed that a novel SNP of g.109Y (intron 5) and two common SNPs of g.221K (intron 5) and g.642R (intron 6) were detected in the NRAMP gene in Indonesian native cattle. In addition, these SNPs have a moderate polymorphic information content (PIC) value (0.30 - 0.50). Therefore, eight (8) haplotypes of the NRAMP1 gene were determined in the present study. Thus, the highest bacterial infection frequency was shown in the TT/GT/AG haplotype. In conclusion, three (3) nonsense SNP in the NRAMP1 gene have the potency as a genetic marker for bacterial resistance trait in Indonesian cattle

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Polymorphisms of the coding region of Slc11a1 (Nramp1) gene associated to natural resistance against bovine brucellosis

Abstract: Communication [Comunicação] Polymorphisms of the coding region of Slc11a1 (Nramp1) gene associated to natural resistance against bovine brucellosis[Polimorfismos na região codificadora do gene Slc11a1 (Nramp1) associados à resistência natural contra brucelose bovina]

Cited by 7 publications

References 12 publications

Resistencia y resiliencia a las enfermedades en las razas de rumiantes locales: un enfoque en América del Sur

Resistencia y resiliencia a las enfermedades en las razas de rumiantes locales: un enfoque en América del Sur

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

NRAMP1 Gene Polymorphism: A Pathogenic Bacterial Resistance Trait in Indonesia Cattle

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