Efficacy of Argentine propolis formulation for topical treatment of canine otitis externa

Abstract

The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms of otitis externa were randomly assigned to double-blinded, controlled clinical trial to evaluate the efficacy of topical formulation with propolis versus a topical placebo in the treatment of otitis externa. The propolis preparation and placebo were administrated into both external ear canals, twice daily for 14 days. Throughout the study, clinical examination and microbiological analysis of dogs ear exudates were made. The most frequent microorganisms isolated in culture media were: Malassezia pachydermatis (54.2%), Staphylococcus aureus (43.8%), coagulase-negative Staphylococcus (25.0%), Pseudomonas aeruginosa (20.8%), Candida albicans (18.8%), Proteus mirabilis (16.7%), Streptococcus spp. (16.7%), Enteroccocus faecalis (12.5%), Escherichia coli (12.5%), Staphylococcus intermedius (6.3%), Klebsiella spp. (4.2%), andCandida glabrata (2.1%). Whereas the control group did not recover from the infectious ear disease, the propolis preparation exhibited antimicrobial activity against most of the microorganisms isolated from samples of the treated group. In addition, no propolis-adverse effects were observed. This allowed propolis-treated patients to show a significant improvement of the clinical parameters. Thus, this new Argentine propolis ear drop formulation may be used for topical treatment of otitis externa in dogs.

A randomized, double-blind, placebo-controlled study to assess the effect of an aqueous extract of Triticum aestivum on canine outer ear inflammation

“…This disease is usually treated through topical therapy with antimicrobial agents (Rougier et al 2005). Concerns regarding antibiotic resistance press the search for alternatives (Lozina et al 2010, Ziech et al 2013, especially considering otitis, were both the causative agents and drugs used are the same in veterinary and human medicine (Lyskova et al 2007, Malayeri et al 2010. Wheat has been used for some time in wound healing and skin ointments (Tillmann et al 2014), and immune-modulatory (Hyung et al 2010), antioxidant (Souza et al 2006), and antibiotic (Ribas et al 2005, Godeiro et al 2010 properties have been described.…”

“…Outer ear otitis is an acute or chronic inflammation of the ear canal, which develops in the proximal portion of the pinna (Lozina et al 2010). It is one of the most common diseases in small animal practice, characterized by clinical signs such as: itchiness, erythema, pain, and a large amount of cerumen (Plischke & Pereira 2012).…”

“…It is one of the most common diseases in small animal practice, characterized by clinical signs such as: itchiness, erythema, pain, and a large amount of cerumen (Plischke & Pereira 2012). The disease has a multifactorial etiology, and treatment is often hampered by growing antibiotic resistance (Lozina et al 2010, Malayeri et al 2010, Ziech et al 2013. Wheat, Triticum aestivum (sin.…”

Atividade antifúngica do óleo essencial de Origanum vulgare frente a Malassezia pachydermatis

“…Além disso, M. pachydermatis tem se mostrado sensível a diferentes extratos vegetais e óleos essenciais de diversos produtos naturais, inclusive em concentrações baixas (Cardoso et al, 2010;Lee e Lee, 2010;Lozina et al, 2010), demonstrando a atividade promissora dos produtos naturais frente ao agente.…”

Effects of season and altitude on biological active certain phenolic compounds levels and partial standardization of propolis

“…Several pharmacological effects have been attributed to propolis, especially ethanolic propolis extracts, such as antibacterial, antioxidant, antiviral, fungicidal, anti-inflammatory, anticarcinogenic, antiapoptotic, immunomodulatory and gastric protective (antiulcer) effects (4,6,13,24). In veterinary medicine, propolis is reportedly active against fungal otitis (8,15) and dermatomycosis in dogs (11), and may also use for treatment of bovine dermatophytosis (7).…”