Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

Albuquerque, Verônica Batista de; Souza, Thales R.; Vivan, Maria Carolina Ribeiro; Ferreira, José Pedro; Frade, Marcelo Carnelli; Perri, S. H. V.; Oliva, Valéria Nobre Leal de Souza

doi:10.1590/s0102-09352010000400007

Cited by 4 publications

(8 citation statements)

References 13 publications

(6 reference statements)

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“…Furthermore, increases in those variables contributed for compensating hypoventilation, which caused high PaCO 2 values. When comparing epidurally administered tramadol with morphine in dogs, Baraka et al (1993) have reported significant respiratory changes such as decreased f R and PaO 2 without variations in PaCO 2 when morphine was used. In one retrospective study of 242 dogs and 23 cats, epidural anesthesia with morphine with or without bupivacaine has been associated with respiratory alterations that decreased P E´C O 2 and increased PaCO 2 (Troncy et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to assess the cardiopulmonary, analgesic, adverse effects, serum concentration of cortisol and plasma levels of levobupivacaine and morphine in bitches undergoing propofol anesthesia and epidural analgesia with levobupivacaine alone or combined with morphine. This was a randomized 'blinded' prospective clinical study using 32 adult bitches weighing 9.8±4.1kg that were admitted for elective ovariohysterectomy. Twenty minutes after administration of acepromazine and midazolam, anesthesia was induced with propofol (4mg kg -1 ) and maintained by a continuous rate infusion (CRI). Each animal was randomly assigned to one of four epidural groups: GL = levobupivacaine alone (0.33mg kg -1 ); GLM0.1 = levobupivacaine and morphine (0.1mg kg -1 ); GLM0.15 = levobupivacaine and morphine (0.15mg kg -1 ); and GLM0.2 = levobupivacaine and morphine (0.2mg kg -1 ). Variables obtained during anesthesia were heart rate, respiratory rate, systolic, mean and diastolic arterial blood pressures, oxyhemoglobin saturation, inspired oxygen fraction, end-tidal carbon dioxide tension, blood gases, serum cortisol, and plasma levels of levobupivacaine and morphine. The onset and duration times of the blockade were recorded. Arterial pressures were significantly increased in all groups at the times of ovarian pedicle clamping. There was a decrease in pH, together with an increase in both PaO 2 and PaCO 2 over time. Serum cortisol levels were increased in TESu compared to TB, T30 and TR. Limb spasticity, muscle tremors, opisthotonos and diarrhea were observed in some animals during propofol infusion and ceased with the end of CRI. Reactions happened at different moments and lasted for different periods of time in each individual. Epidural with levobupivacaine alone or combined with morphine allowed for ovariohysterectomy to be performed under low propofol infusion rates, with minimal changes in cardiovascular variables and in serum cortisol levels. Adverse effects were observed in very few animals in each group. Keywords: dog, opioid, ovariohysterectomy, blood gas, regional anaesthesia (0,33mg/kg); GLM0,1 = levobupivacaína + morfina (0,1mg/kg); GLM0,15 = levobupivacaína + morfina (0,15mg/kg) e GLM0,2 = levobupivacaína + morfina (0,2mg/kg RESUMO Objetivou-se avaliar os efeitos cardiovasculares, analgésico, adversos, a concentração sérica de cortisol e os níveis plasmáticos de levobupivacaína e morfina em cadelas submetidas à infusão contínua de propofol e analgesia peridural com levobupivacaína isolada ou associada à morfina. Para tanto, realizou-se um estudo clínico prospectivo randomizado com 32 cadelas adultas pesando 9,8 ± 4,1kg, que foram submetidas à ovário-histerectomia eletiva. Vinte minutos após a administração de acepromazina e midazolam, os animais foram induzidos com propofol (4mg/kg) e mantidos por uma infusão contínua (CRI) do mesmo fármaco. Cada animal foi alocado aleatoriamente em um dos quatro grupos: GL = levobupivacaína isolada

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Section: Discussionmentioning

confidence: 99%

“…The onset time and duration of the blockade were determined according to Albuquerque et al (2010). Analgesia at the postoperative period was assessed through visual analog scale (VAS) for pain.…”

Section: Methodsmentioning

confidence: 99%

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Albuquerque¹,

Araújo²,

Ferreira³

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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“…It is capable of providing analgesia and muscle relaxation in the retroumbilical region (SOUZA et al, 2013) and causes minimal cardiorespiratory changes. It also improves control over postoperative pain, reduces transoperative stress (ALBUQUERQUE et al, 2010), is safe and efficient, and can reduce the concentration of inhaled anesthetic required for the maintenance of proper anesthesia (VALVERDE, 2008;ITAMI et al, 2011;BOSMANS et al, 2011;NATALINI et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Ropivacaine, a pure S enantiomer, provides significant advantages over its precursor, bupivacaine, including reduced motor nerve blockade, lower-intensity action on the fibers responsible for motor action, and lower cardiotoxicity. However, its use is limited because of its high cost ( VAN DE VELDE et al, 2007;SILVA et al, 2008;ALBUQUERQUE et al, 2010;SOUZA et al, 2013). Local anesthetics, which produce sensory block and immediate engine, when combined with ED opioids, increase the duration and intensity of analgesic effect, contributing to the acceleration in the postoperative recovery of the animal (VALADÃO et al, 2002;BASSO et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Ropivacaine when combined with an opioid analgesic is efficient, but when administered alone is not able to provide adequate analgesia during an orthopedic surgical procedure (ADAMI et al, 2012). A small volume (0.2 ml·kg -1 ) does not provide the suitable blocking time required for conducting OSH and therefore requires intraoperative analgesic rescue (ALBUQUERQUE et al, 2010;REGALIN et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Effects of epidural anesthesia with tramadol, ropivacaine or tramadol-ropivacaine combination, in bitches undergoing ovariohysterectomy under anesthesia with isoflurane

Winter

Monzem

Spiller

et al. 2016

SCA

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Epidural anesthesia is a locoregional anesthetic technique that provides analgesia and muscle relaxation in the-retroumbilical region. The combination of opioids and local anesthetics increased the intensity and duration of analgesia by causing immediate motor and sensory nerve blockade, and improved recovery after surgery. The objective was to comparatively evaluate the trans- and postoperative cardiorespiratory and analgesic effects of epidurally administered tramadol, ropivacaine and tramadol-ropivacaine combination in dogs undergoing elective ovariohysterectomy. The effect of isoflurane concentration was also evaluated. This study was performed on 24 female mongrel dogs, pre-medicated with chlorpromazine (0.5 mg kg-1, IV) and, anesthetized with propofol and isoflurane. The dogs were randomly divided into three groups. The first group receveid epidural tramadol (2 mg kg-1, GT group), the second group received ropivacaine (1.5 mg kg-1, GR group), and the third group received a tramadol-ropivacaine combination at the above-mentioned doses (GTR group). At pre-defined time points, classified into pre-, trans-, and postoperative periods, cardiorespiratory variables and analgesia were analyzed for a period of up to 420 min following epidural anesthesia. The check analgesia was check of approximately 105, 217 and 382 minutes, in GR, in GT and GTR respectively, and no cardiovascular and respiratory depression. The drugs used in this study are considered safe and effective for ovariohysterectomy due to the cardiorespiratory stability and trans-operative analgesia provided by them. However, the combination of ropivacaine and tramadol ensured a greater reduction in the inhaled anesthetic dose and better analgesia during in the postoperative period.

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Bloqueio motor e sensitivo da lidocaína ou da ropivacaína peridural em cães

Thomas

Francini

Sinotti

et al. 2020

Arq. Bras. Med. Vet. Zootec.

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RESUMO Objetivou-se avaliar o bloqueio sensitivo e motor da administração peridural de 0,2mL/kg de duas concentrações de ropivacaína em comparação à lidocaína em cães. Utilizaram-se 24 cães, distribuídos em quatro grupos: NaCl a 0,9% (GS), lidocaína a 2% (GL), ropivacaína a 0,5% (GR5) e ropivacaína a 0,75% (GR7,5). Avaliaram-se a presença de movimentação espontânea, deambulação, sensibilidade superficial e profunda nos momentos cinco, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180, 240 e 300 minutos após peridural. O retorno à movimentação espontânea foi semelhante entre GL (42,50 ± 6,12) e GR7,5 (69,2 ± 58,9). O tempo para deambulação foi mais prolongado em GR7,5 (107,5 ± 79,3) que em GS (9,2 ± 3,8) e em GR5 (32,5 ± 20,9). O retorno da sensibilidade profunda foi maior em GR 7,5 (152,5 ± 89,2) que em GS (5,8 ± 2,0), GR5 (46,7 ± 46,3) e GL (52,5 ± 20,7). O tempo de retorno da sensibilidade superficial foi maior em GR7,5 (205,0 ± 129,3) que em GS (7,5 ± 2,7), GL (72,5 ± 19,9) e GR5 (97,5 ± 55,1). Apesar do retorno precoce da movimentação, ropivacaína 0,75% está relacionada a tempo prolongado de recuperação da função muscular e bloqueio sensitivo mais prolongado que lidocaína e ropivacaína 0,5%.

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Influência do butorfanol sobre os períodos de latência e de ação da ropivacaína pela via peridural na ovariossalpingo-histerectomia em cadelas

Cited by 4 publications

References 13 publications

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Epidural levobupivacaine alone or combined with different morphine doses in bitches under continuous propofol infusion

Effects of epidural anesthesia with tramadol, ropivacaine or tramadol-ropivacaine combination, in bitches undergoing ovariohysterectomy under anesthesia with isoflurane

Bloqueio motor e sensitivo da lidocaína ou da ropivacaína peridural em cães

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