Caracterização da mitocôndria isolada de fígado de tilápia-do-nilo (Oreochromis niloticus) e alterações da bioenergética mitocondrial causadas pela exposição herbicida oxifluorfena

Abstract

Caracterização da mitocôndria isolada de fígado de tilápia-do-nilo (Oreochromis niloticus)e alterações da bioenergética mitocondrial causadas pela exposição ao herbicida oxifluorfena

Biochemical and genotoxic effects of a commercial formulation of the herbicide tebuthiuron in Oreochromis niloticus of different sizes

“…This impressive productivity is supported by the extensive use of several agrochemicals for pest control that, as a consequence, can result in significant negative impacts on the environment. In the case of herbicides alone, more than 30 compounds present in different formulations are used in sugarcane cultivation in Brazil (Martini & Durigan, 2004), such as 2,4-D, acetochlor, ametryne, clomazone, atrazine, diuron, hexazinone, glyphosate and tebuthiuron, though the toxic effects of some of these compounds on non-target organisms are not known (Oruç & Üner, 2000;Cattaneo et al, 2008;Xiao et al, 2006;Paiva and Takahashi, 1996;Sikkema & Shropshire, 2007;Nwani et al, 2011;Akcha et al, 2012;Mei et al, 2012;Lancetõt et al, 2013;Bicalho & Langenbach, 2013). Tebuthiuron (1-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea) is a pre-and post-emergent substituted urea herbicide used for the control of broadleaf and woody weeds, grasses and brush through the inhibition of photosystem II.…”

“…Because biomarker responses can vary significantly according to the size of the fish (Peixoto & Santos, 2009), a factor that can indicate differences in the organism's susceptibility to the pollutant, we were also interested in evaluating the discrepancies in biomarker responses among fish of the same species (O. niloticus) but with significant differences in body length and weight. The sizes of aquatic animals have been shown to play an important role in tissue pollutant loads.…”