Effect of selenium-vitamin E injection in selenium-deficient dairy goats and kids on the Mexican plateau

Abstract

Three experiments were carried out to determine the optimum selenium-vitamin E injection level to maintain acceptable blood selenium (Se) status of does and kids, as well as to determine the relation of that status to mortality rates in kids. In experiment 1, 238 goats were assigned to one of three groups during the mating period: A1-control, A2-0.06mgSe+0.8IU vitE/kgBW and A3-0.125mgSe+1.7IU vitE/kgBW. No differences (P>.05) for fertility and prolificacy were observed among the groups. Blood Se concentration did not differ among Se-vit E groups and control group before injection, and both groups showed Se deficient condition. There was a trend (P<.05, 32%) to increase Se blood level 60 days post-treatment, but difference was not observed between A2 and control groups, while difference (P<.05; 103%) was observed between A1 and A2 groups vs high Se injection (A3 group). In experiment 2, 48 goats were divided into four groups: B1-control, B2-0.125mgSe+1.7IU vitE/kgBW, B3-0.25mgSe+3.4IU vitE/kgBW and B4-0.31mgSe+4.2IU vitE/kgBW. The B4 group reached the highest concentration at the third month after injection (0.11 ppm), then started to decline after 100 days, reaching a value slightly higher than B2 and B3 on the 135 th day of pregnancy. Results of B2 and B3 groups were slightly higher that those of B1 (P<0.05). In experiment 3, 194 kids (3 to 7 days postpartum) born from Se-deficient goats were used to compare the effectiveness of Se injection. They were divided into three groups: C1-control, C2-0.3mgSe+4.2IU vit E/kg BW and C3-0.6mgSe+8.4IU vit E/kg BW. C1 showed the highest percentage of mortality (60%) as compared to treated Se groups, that scored equal percentage of deaths (22% averaged). The concentration of Se in blood, on day 20 th after the onset of the treatment rapidly increased, according with level of Se injection. The 0.3mgSe/kgBW Se injection increased the blood Se concentration in pregnant goats and it was effective to prevent white muscle disease lesions, besides enhancing the survival of kids until weaning. 125mgSe+1,25mgSe+3,31mgSe+4,

Effect of selenium and vitamin E on oxidative stress in lambs experimentally infected with Haemonchus contortus

“…The GSH-Px increases in blood circulation as a result of the greater availability of blood selenium, as it is dependent on this element (Rooke et al 2004;Halliwell and Gutteridge 2007). The higher GSH-Px values at T0 in the group supplemented with selenium only is related to its application thirty days prior to the experimental period, as selenium reaches its peak action at approximately 60 days (Ramirez-Bribiesca et al 2005).…”

Perfil proteico e metabolismo oxidativo de cordeiros experimentalmente infectados pelo Haemonchus contortus e suplementados com selênio e vitamina E

“…Os cordeiros apenas suplementados com selênio e vitamina E (G4), apesar de terem recebido, durante todo o período experimental, uma dieta com baixo teor proteico, exibiram um incremento na produção de proteínas totais e de albumina aos 60 e 80 dias (Tabela 1). De acordo com RAMIREZ-BRIBIESCA et al (2005), o pico de ação do selênio pode ocorrer em até 60 dias após sua aplicação, sendo, provavelmente, a suplementação desse mineral o responsável pelo melhor desempenho proteico nos cordeiros desse grupo. Quanto à fração betaglobulina, valores mais elevados foram detectados no T3, T4 e T5 do G4, em relação ao grupo 1.…”

Activities of enzyme adenosine deaminase in serum of lambs experimentally infected with Haemonchus contortus and treated with selenium and copper

“…That is because, according to the literature, the selenium dose reaches peak blood within 60 days after administration (Ramirez-Bribiesca et al, 2005). Copper was administered at T0 and 30 days later.…”