Cytological and histopathological aspects of lipomas in Bothrops moojeni

Cassali, Geovanni Dantas; Amaral, Vivian Ferreira do; Silva, A. E.; Macrì, I; Maciel, Rosemiro De Menezes

doi:10.1590/s0102-09352004000600017

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The occurrence of neoplasms in snakes has been described in several previous studies. For instance, Cassali, Amaral, Silva, Macri and Maciel (2004) recorded subcutaneous benign neoplasms in five Bothrops moojeni individuals kept in captivity for an average period of 11.4 years. These tumors were diagnosed as lipomatous tumors of the spindle cell lipoma subtype.…”

Section: Introductionmentioning

confidence: 99%

Oral adenocarcinoma observed in Boa constrictor maintained in captivity

Pereira

Berna

Costa

et al. 2022

Semina: Ciênc. Agrár.

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Information on neoplasms in animals has increased over time, and these studies have helped in the management of reptiles that present tumors. There are similar incidences of neoplasms between homeothermic and ectothermic animals. Furthermore, there are usually more than one type of tumor present. The treatment of wild animals afflicted with cancer usually happens late, contributing to their low life expectancy. Thus, the present work aimed to describe an infrequent case of oral tumor in Boa constrictor. The tumor was observed in an adult female animal, raised in an exhibition area of the Zoo and Botanical Park of the Emílio Goeldi Museum, located in Belém, State of Pará, Brazil. Macroscopically, the mass presented morphologically with an irregular, multilobulated surface, color that varied from white to grey, hemorrhagic areas and its extension was 3.9 x 2.3 cm. The neoplasm was surgically removed, and the histopathological evaluation revealed an adenocarcinoma, with a papillary-like development pattern and a moderate degree of differentiation. The animal died three months after diagnosis due to starvation. The necropsy showed that there was tumor recrudescence and no metastases. Given the impossibility of surgical removal with a greater margin of safety, and adjuvant therapies, this condition favoured the resurgence of the neoplasm. This compromised the animal’s ability to feed and consequently lead to death. Malignant neoplasms in reptiles may have an unfavourable clinical evolution for the maintenance of life, requiring specific therapeutic care such as chemotherapy. Scientific contributions on tumors in these animals are essential for the medical treatment of wild animals, and the conservation of wild species.

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Section: Introductionmentioning

confidence: 99%

Oral adenocarcinoma observed in Boa constrictor maintained in captivity

Pereira

Berna

Costa

et al. 2022

Semina: Ciênc. Agrár.

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“…These can be of epithelial, mesenchymal or lymphoid origin, but mesenchymal is the most common (Kusewitt et al 1997, Catão-Dias & Nichols 1999, Stedman et al 2010. Among the tumors of the oral cavity and the integument of snakes, fibrosarcoma is the most reported, followed by others that can occur in various body sites, such as melanoma, sarcoma, spindle cell carcinoma, squamous cell carcinoma, malignant lipoma, chromatophoroma and adenocarcinoma (Hernandez-Divers & Garner 2003, Garner 2004, Cassali et al 2004, Keck et al 2011. However, there is still a lack of information and studies on the cause and the biological behavior of neoplasms in snakes, particularly concerning fibrosarcomas (Orós et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

et al. 2015

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RESUMO.-[Fibrossarcoma oral em jararaca (Bothrops pubescens): aspectos anatomopatológicos e imuno-histoquímicos.] Uma serpente de cativeiro, fêmea, quatro anos de idade, do gênero Bothrops apresentou aumento de volume no lado esquerdo da cavidade oral, sugerindo tratar--se de neoplasma. A massa foi removida cirurgicamente e enviada para exame anatomopatológico. Dois meses depois foi observado novo aumento de volume no mesmo local, sugerindo recidiva. A lesão foi removida por completo e também enviada para análise. Histologicamente, as duas amostras consistiam de massa altamente celular, composta por células anaplásicas fusiformes organizadas em feixes entrelaçados e distribuídos por toda extensão tecidual e, ocasionalmente, células poligonais arranjadas em fascículos irregulares. A coloração de tricrômico de Masson apresentou quantidade modesta de colágeno sustentando as células neoplásicas. Não foi observado conteúdo PAS-positivo no citoplasma das células neoplásicas. Os achados histológicos e histoquímicos indicavam tratar-se de neoplasma de célu-las fusiformes, porém não era possível sua classificação. A E-mail: acmotta@upf.br A 4-year-old female captive-bred snake of the genus Bothrops showed swelling on the left side of the oral cavity, suggesting the development of neoplasia. The mass was removed surgically and sent for pathological examination. Two months later a new increase in volume in the same site was observed, suggesting recurrence. The lesion was completely removed and sent for pathological analysis. Histologically, the two-samples consisted of a mass with highly-cell density composed of spindle-shaped anaplastic cells arranged in interwoven bundles, distributed throughout the tissue extension and, occasionally, polygonal cells arranged in irregular fascicles. The Masson trichrome staining showed modest amount of collagen supporting the neoplastic cells. PAS-positive content was not observed in the cytoplasm of neoplastic cells. Histological and histochemical findings indicated that it was a spindle cell neoplasm, but the classification was not possible. Immunohistochemistry was requested and performed using the streptavidin-biotin-peroxidase method. The markers used were anti-vimentin, anti-PCNA, anti-EMA, anti-melan A and anti-melanosome, anti--desmin, anti-actin, anti-CD68 and anti-S100protein. The neoplastic cells were immunoreactive for vimentin and PCNA and negative for the other antibodies. The morphology characterization, histochemical and immunohistochemical analysis of neoplastic cells allowed the definitive diagnosis of oral fibrosarcoma. Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects imuno-histoquímica foi requisitada e realizada pelo método streptavidina-biotina-peroxidase, utilizando os anticorpos anti-vimentina, anti-PCNA, Anti-EMA, anti-melan A, anti--HMB45, anti-desmina, anti-actina, anti-CD68 e anti-proteí-na S-100. As células neoplásicas foram imunorreativas para vimentina e PCNA e, negativas para os demais anticorpos. A ca...

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