Cutaneous and Subcutaneous Soft Tissue Tumours in Snakes: A Retrospective Study of 33 Cases

Dietz, Janosch; Heckers, Kim O.; Aupperle, H.; Pees, Michael

doi:10.1016/j.jcpa.2016.05.009

Cited by 18 publications

(14 citation statements)

References 22 publications

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“…NARs demonstrate a wide range of neoplasms 76 , and the overall neoplasm rate in the literature analysis was 6.2% (824/13,299 NARs; Supplementary Table S2). Yet only 3.6% 77 to 5.5% 78 of all tumours are located in the bone, resulting in only a small number of neoplasms of the skeletal system 79 . It has to be considered that only a small number of studies have addressed bone involvement in neoplastic diseases overall.…”

Section: Differential Diagnosis Based On Phylogenetic Disease Bracketmentioning

confidence: 99%

A comprehensive diagnostic approach combining phylogenetic disease bracketing and CT imaging reveals osteomyelitis in a Tyrannosaurus rex

Hamm

Hampe

Schwarz

et al. 2020

Sci Rep

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Traditional palaeontological techniques of disease characterisation are limited to the analysis of osseous fossils, requiring several lines of evidence to support diagnoses. This study presents a novel stepwise concept for comprehensive diagnosis of pathologies in fossils by computed tomography imaging for morphological assessment combined with likelihood estimation based on systematic phylogenetic disease bracketing. This approach was applied to characterise pathologies of the left fibula and fused caudal vertebrae of the non-avian dinosaur Tyrannosaurus rex. Initial morphological assessment narrowed the differential diagnosis to neoplasia or infection. Subsequent data review from phylogenetically closely related species at the clade level revealed neoplasia rates as low as 3.1% and 1.8%, while infectious-disease rates were 32.0% and 53.9% in extant dinosaurs (birds) and non-avian reptiles, respectively. Furthermore, the survey of literature revealed that within the phylogenetic disease bracket the oldest case of bone infection (osteomyelitis) was identified in the mandible of a 275-million-year-old captorhinid eureptile Labidosaurus. These findings demonstrate low probability of a neoplastic aetiology of the examined pathologies in the Tyrannosaurus rex and in turn, suggest that they correspond to multiple foci of osteomyelitis.

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Section: Differential Diagnosis Based On Phylogenetic Disease Bracketmentioning

confidence: 99%

A comprehensive diagnostic approach combining phylogenetic disease bracketing and CT imaging reveals osteomyelitis in a Tyrannosaurus rex

Hamm

Hampe

Schwarz

et al. 2020

Sci Rep

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“…Common box turtle Adenocarcinoma Mader (1996) Testudo graeca Spur-thighed tortoise Adenoma Mader (1996) Testudo hermanni Hermann's tortoise Lymphoma, neurilemmoma Mader (1996) Testudo horsfieldii Afghan tortoise Fibroma, fibroadenoma Mader (1996) Thamnophis sauritus Ribbon snake Lipoma Dietz et al (2016) (2006); Rush et al (2012) a We tried to provide a comprehensive list of examples of neoplasia in wild and captive animals, but understandably the list cannot be complete due to limited space. Review articles were used primarily due to restricted space for citations.…”

Section: Terrapene Carolinamentioning

confidence: 99%

Cancer Prevalence and Etiology in Wild and Captive Animals

Madsen

Arnal

Vittecoq

et al. 2017

Ecology and Evolution of Cancer

106

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“…Cutaneous and subcutaneous tumors are uncommon in snakes . A single retrospective study of these tumors in snakes reported that soft tissue sarcomas, melanomas, and squamous cell carcinomas were the most common tumors in colubrid snakes, the family that includes corn snakes .…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, this is the first case of a corn snake with infiltrative lipomas diagnosed by cytology and CT. In snakes, infiltrative lipomas have been diagnosed at necropsy or after surgery . The minimally invasive procedures used in this study, not only allowed an antemortem diagnosis but also helped to decide if a debulking surgery should be pursued.…”

Section: Discussionmentioning

confidence: 99%