Cancer Prevalence and Etiology in Wild and Captive Animals

Madsen, Thomas; Arnal, Audrey; Vittecoq, Marion; Bernex, Florence; Abadie, Jérôme; Labrut, Sophie; Garcia, Déborah; Faugère, Dominique; Lemberger, Karin; Beckmann, Christa; Roche, Benjamín; Thomas, Fréderic; Újvári, Beáta

doi:10.1016/b978-0-12-804310-3.00002-8

Cited by 84 publications

(124 citation statements)

References 125 publications

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“…In conclusion, every new recorded case of tumors in wild animals can provide valuable data for studies in comparative oncology and the etiology of neoplastic diseases (MADSEN et al, 2017).The present case of an intestinal adenocarcinoma, described here with all the typical effects of the tumor on the animal, is to our knowledge the first report of this type of tumor in a European brown bear (Ursus arctos), as well as in other bear species.…”

Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 79%

“…The small number of tumors diagnosed in bears, similar to all free-living wild animals, can be at least partially explained as a result of the low incidence of inbreeding in contrast to domestic animals (CULLEN and BREEN, 2017;MADSEN et al, 2017). The low incidence of reports of tumors in wild animals is also based on the effect of natural selection whereby animals suffering from neoplastic diseases usually do not die primarily as a consequence of the tumor.…”

Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 99%

“…The low incidence of reports of tumors in wild animals is also based on the effect of natural selection whereby animals suffering from neoplastic diseases usually do not die primarily as a consequence of the tumor. Due to the malignant process animals develop infectious and parasitic diseases and suffer exhaustion thus becoming easier prey to their natural predators (MADSEN et al, 2017).…”

Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 99%

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Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Hohšteter¹,

Šoštarić-Zuckermann²,

Reljić³

et al. 2018

Vet. arhiv

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This article presents the first case of intestinal adenocarcinoma in a free living, culled 12 year old, European female brown bear (Ursus arctos), with its characteristic macropathological and histopathological manifestations. Necropsy revealed thoracic gunshot injuries (compassionate shot) and the poor physical condition of the animal, with body fat loss and musculature atrophy. An infiltrative mass protruded the jejunal wall with infiltration of the mesentery, visceral and parietal peritoneum, and distal parts of the colon and rectum. The histopathological examination presented an infiltrative, unencapsulated, moderately cellular neoplastic mass, composed of an epithelial cell population, forming irregular nests, papillary and ribbon like structures and small number of tubules, surrounded by an extensive desmoplastic reaction. Within the tumor a small number of cysts filled with mucin were noted. The epithelial neoplastic cells exhibited mild anisocytosis and anisokaryosis, and a low mitotic index. Histochemical Van Gieson staining showed strong positivity in the desmoplastic proliferation. The epithelial tumor cells were positively imunostained with cytokerain, and stromal cells with vimentin. The histological features presented are characteristic of intestinal adenocarcinomas, of the mixed tubular and mucinous type, with a prominent scirrous reaction.

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Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 79%

Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 99%

Section: Hohšteter Et Al: Intestinal Carcinoma In a European Browmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Hohšteter¹,

Šoštarić-Zuckermann²,

Reljić³

et al. 2018

Vet. arhiv

View full text Add to dashboard Cite

show abstract

“…Despite cancer (both transmissible and non-transmissible) being an emerging important factor influencing life history traits, even at early stages (15)(16)(17)(18), little is known regarding the reciprocal links between the social environment and the development and progression of this illness. Increasing evidence demonstrates that oncogenic phenomena are extremely prevalent in host populations, and not just in post-reproductive individuals as previously believed (19). It is still largely unclear for both animals and humans how specific social group composition can directly affect tumor progression, and vice versa.…”

Section: Introductionmentioning

confidence: 96%

An interaction between cancer progression and social environment in Drosophila

et al. 2017

Preprint

Self Cite

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The influence of oncogenic phenomena on the ecology and evolution of animal species is fast becoming an important research topic. Similar to host-pathogen interactions, cancer negatively affects host fitness, which should lead to the selection of host control mechanisms, including behavioral traits that best minimize the proliferation of malignant cells. Social behavior is one such trait, which is suggested to influence cancer progression. While the ecological benefits of sociality in gregarious species are widely acknowledged, only limited data are available on the role of the social environment on cancer progression. Here, we exposed adult Drosophila, with colorectal-like tumors, to different social environments. First, we show that cancerous flies kept in complete isolation exhibit increased tumor progression. Yet, more surprisingly, we find that cancerous flies, kept in groups with other noncancerous individuals, also develop tumors at a faster rate compared to those kept with other cancerous conspecifics, suggesting a strong impact of social group composition on cancer growth. Finally, we show that flies can discriminate between individuals at different stages of tumor growth and selectively choose their social environment accordingly. Control flies actively avoid flies with cancer but only at the later stages of tumor development, whereas cancerous flies display strong social interactions with cancerous flies in the early stages of tumor growth. Our study demonstrates the reciprocal links between cancer and social interactions, as well as highlighting how sociality impacts health and fitness in animals and its potential implications for disease ecology and ecosystem dynamics.

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“…According to the literature, neoplasia is a growing concern in captive wild animals (Madsen et al, 2017;McAloose & Newton, 2009;Pesavento, Agnew, Keel, & Woolard, 2018). As captive animals are living longer compared to their wild counterparts (Tidière et al, 2016) and are under continuous veterinary care, neoplasias are more frequently diagnosed and encountered in captivity (Effron, Griner, & Benirschke, 1977;Hubbard, Schmidt, & Fletcher, 1983;Lombard & Witte, 1959;Madsen et al, 2017;Owston, Ramsay, & Rotstein, 2008). Finding a potential biomarker to help aid in diagnosis and monitoring of cancer could be an added minimally invasive method to determine the development of cancer, and is therefore a crucial step in zoo medicine.…”

Section: Introductionmentioning

confidence: 99%

Copper isotopes as possible neoplasia biomarkers in captive wild felids

Gourlan

Douay²,

Télouk

2019

Zoo Biology

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The longevity of zoo animals is increasing due to continuous improvement in husbandry and veterinary medicine. However, increasing age is correlated to a higher prevalence of neoplasia. Despite tremendous improvement in diagnoses and monitoring capacities, cancers are still a challenge for veterinarians within the global zoo community. The recent use of copper isotopes as biomarkers for neoplasia in both human and veterinary medicine is a promising and cost‐effective diagnostic tool. Two hundred and twenty‐nine serum samples from 10 different species of wild felids under human care were processed through mass spectrometry to determine the ratio of heavy and light copper isotopes (65Cu/63Cu). The results of this preliminary study exhibit an important variability between felid species, with a ratio ranging between −1.71 and 0.63. Additionally, copper isotopes seem to be a promising diagnostic tool in monitoring cancer in wild animals, as in human medicine, where the isotopic ratio decreases significantly with time in the presence of a tumor.

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Cancer Prevalence and Etiology in Wild and Captive Animals

Cited by 84 publications

References 125 publications

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report

An interaction between cancer progression and social environment in Drosophila

Copper isotopes as possible neoplasia biomarkers in captive wild felids

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