Aspectos epidemiológicos dos pólipos e lesões plano-elevadas colorretais

Neto, Juvenal da Rocha Torres; Arcieri, Jofrancis Santos; Teixeira, Fábio Ramos

doi:10.1590/s0101-98802010000400006

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Non-neoplastic polyps could be a result of abnormal maturation of mucosa, infl ammation, or alteration of cellular architecture. Adenomatous polyps are premalignant lesions that may precede colorectal cancer (Torres et al, 2011), thus their detection is very important for clinical diagnosis. Colorectal adenocarcinoma originates from epithelial cells that are able to infi ltrate into the Volume 31, Number 1, p. [10][11][12][13][14][15][16][17][18]2015 underlying layers, submucosa, and muscle of colon and rectum (Petibois and Déléris, 2006).…”

Section: Introductionmentioning

confidence: 99%

Biochemical imaging of normal, adenoma, and colorectal adenocarcinoma tissues by Fourier transform infrared spectroscopy (FTIR) and morphological correlation by histopathological analysis: preliminary results

et al. 2015

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Introduction:The colorectal cancer is a major health problem worldwide. Histology is considered the gold standard for differential diagnosis. However, it depends on the observer's experience, which can lead to discrepancies and poor results. Spectroscopic imaging by Fourier transform infrared (FTIR) is a technique that may be able to improve the diagnosis, because it is based on biochemical differences of the structural constituents of tissue. Therefore, the main goal of this study was to explore the use of FTIR imaging technique in normal colon tissue, colorectal adenoma, and adenocarcinoma in order to correlate their morphological structures with their biochemical imaging. Methods: Samples were collected from normal (n = 4), adenoma (n = 4), and adenocarcinoma human colorectal tissue (n = 4) from patients undergoing colonoscopy or surgical resection of colon lesions. The samples were sectioned with a cryostat in sequential sections; the fi rst slice was placed on CaF 2 slide and the second slice was placed on glass slide for histological analysis (HE staining). The cluster analyses were performed by the software Cytospec (1.4.02) . Results: In normal samples, biochemical analysis classifi ed six different structures, namely the lamina propria of mucous glands (epithelial cells and goblet cells), central lumen of the gland, mucin, and conjunctive tissue. In samples with adenoma and adenocarcinoma, altered regions could also be identifi ed with high sensitivity and specifi city. Conclusion: The results of this study demonstrate the potential and viability of using infrared spectroscopy to identify and classify colorectal tissues.

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Section: Introductionmentioning

confidence: 99%

Biochemical imaging of normal, adenoma, and colorectal adenocarcinoma tissues by Fourier transform infrared spectroscopy (FTIR) and morphological correlation by histopathological analysis: preliminary results

et al. 2015

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Tissues analysis

Bunaciu¹,

Aboul‐Enein²,

Hoang³

2020

Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences

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Pathological findings of colorectal polyps analyzed in Curitiba – Brazil

Nisihara

Fudalli

Turra

et al. 2017

Journal of Coloproctology

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Context Colorectal cancer is the third leading cause of death from malignancy in the world and the fourth leading cause in Brazil's ranks. Adenomatous polyps are considered premalignant lesions, and its resection reduces both morbidity and mortality rates. Objectives Investigate the prevalence of premalignant lesions and correlate it with age and gender, as well as with the lesion found profile: location, morphology, histology and grade dysplasia. Methods This was a retrospective, observational and descriptive study. We analyzed and tabulated results of polyps reports sent to Pathology Laboratory in the period ranging from January 1 to December 31, 2013, in Curitiba, Paraná, Brazil. Results We analyzed 4640 reports of colorectal polypectomy, coming from 3089 patients, of whom 97.6% were examined by colonoscopy. Concerning gender, 56.5% were female and 43.5% were male. The mean age was 57.6 years (ranging from 15 to 92 years). The predominant removal areas of polyps were rectum in 26.2% and sigmoid in 24.2% cases. About histological aspects, the most common type – adenoma – was present in 75.1% polyps, of which 74.2% were tubular and 21.7% were serrated. Among the non-adenomatous polyps, hyperplastic prevailed with 88.7% cases. Malignancy was observed in 100 cases (2.15%). Conclusion This study showed higher incidence of colorectal polyps in women, although adenocarcinomas are equally distributed in both sexes. In addition, the average age of patients undergoing colonoscopy is decreasing. Furthermore, 2.15% polyps sent for pathology analysis were found to be malignant.

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Aspectos epidemiológicos dos pólipos e lesões plano-elevadas colorretais

Cited by 4 publications

References 29 publications

Biochemical imaging of normal, adenoma, and colorectal adenocarcinoma tissues by Fourier transform infrared spectroscopy (FTIR) and morphological correlation by histopathological analysis: preliminary results

Biochemical imaging of normal, adenoma, and colorectal adenocarcinoma tissues by Fourier transform infrared spectroscopy (FTIR) and morphological correlation by histopathological analysis: preliminary results

Tissues analysis

Pathological findings of colorectal polyps analyzed in Curitiba – Brazil

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