Estudo demográfico do câncer de canal anal e ânus no estado de Sergipe

Neto, Juvenal da Rocha Torres; Prudente, Ana Carolina Lisboa; Santos, Ronmel Lisboa dos

doi:10.1590/s0101-98802007000200010

Cited by 4 publications

(6 citation statements)

References 8 publications

(4 reference statements)

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“…Anal canal neoplasm is not frequent in the gastrointestinal tract, corresponding to 1 to 2% of large intestine cancers, and 3 to 3.5% of anorectal tumors. In Sergipe, its incidence it 0.18 to 0.83 per 100,000 people/year 3,10 . In this study, this corresponded to 11 diagnosed patients who were followed-up at the coloproctology service of Hu/uFS, which reinforces the idea that this is the least frequent tumor in the digestive tract.…”

Section: Discussionmentioning

confidence: 99%

“…There are reports regarding the increased prevalence of anus neoplasm in homosexual male patients, maybe due to the association with HPV. This fact could be the cause for a higher prevalence of anus neoplasm among men than young women 3,5 .…”

Section: Discussionmentioning

confidence: 99%

“…It is more prevalent after the sixth decade of life, and some of the risk factors associated with the neoplasm are: infection by the human papillomavirus (HPV), subtypes 16 and 18, smoking and immunosuppression; it is also more prevalent among patients who have the human immunodeficiency virus (HIV) around the third and fourth decades of life, due to the immunologic depression [2][3][4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

“…In a study conducted in Sergipe, which involved almost all databases of pathology laboratories in the State, the incidence rate ranged from 0.18 to 0.83 per 100,000 people, with mean age of 63.8 years; also, there is the proportion of 3.3 women for each man who have the anal carcinoma 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Since 1974, with the work conducted by Nigro, the treatment of choice for cases of anus neoplams has been radiotherapy associated with chemotherapy as the initial treatment, with the use of mitomycin and 5-fluorouracil; cisplatin was the alternative when mitomycim was being tested 2,3,7,9,[11][12][13] . The surgical treatment with abdominoperineal resection can be used as rescue therapy 2,9,11 .…”

Section: Introductionmentioning

confidence: 99%

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Anus neoplasm: study of a case series

Fernandes¹,

Santana²,

Júnior³

et al. 2011

J. Coloproctol. (Rio J.)

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Anus neoplasm accounts for 2 to 4% of colorectal tumors, being more prevalent around the seventh and the eighth decades. Females are mostly affected, and the ratio is 3:1. Its increased prevalence amongst the population in the past years is probably related to the higher number of people that are affected by sexually transmitted diseases, mainly human papillomavirus (types 16 and 18, mostly) and/or the human immunodeficiency virus. Diagnosis is based on clinical findings and anatomopathological tests. The treatment of choice is radiochemotherapy, and the rescue surgery with abdominoperineal resection is used for recurrence and persistence cases. A retrospective and prospective longitudinal observational study was performed with 11 patients diagnosed with anal neoplasm from 2004 to 2010. Six (54.5%) were females and five (45.5%) were males. The incidence was higher in the sixth decade, at the mean age of 54.45 years. The most frequent histological type observed was the epidermoid carcinoma, and the most frequent cell differentiation type was the moderately differentiated. Chemotharapy associated with radiotherapy was used in 81.9% of the patients, and abdominoperineal resection was necessary as a rescue surgery in 18.2% of the patients.
Neoplasias do ânus correspondem de 2 a 4% dos tumores de intestino grosso, sendo predominante nas sétima e oitava décadas. A maior prevalência é em gênero feminino, com proporção de 3:1. O aumento da prevalência na população nos últimos anos provavelmente está relacionado ao número maior de pessoas com doenças sexualmente transmissíveis, principalmente o papilomavírus humano (tipos 16 e 18, mais comumente) e/ou o vírus da imunodeficiência humana. O diagnóstico é feito a partir de achados clínicos somados ao exame anatomopatológico. O tratamento de escolha baseia-se na radioquimioterapia, sendo a cirurgia de resgate com amputação abdominoperineal utilizada para casos de recidiva ou persistência. Foi feito um estudo observacional longitudinal retrospectivo e prospectivo, com 11 pacientes diagnosticados com neoplasia anal no período de 2004 a 2010. Seis (54,5%) eram do gênero feminino e 5 (45,5%) do masculino. O pico de incidência foi em sexta década, com média de idade de 54,45 anos. O tipo histológico mais encontrado foi o carcinoma epidermoide (72,7%), sendo o moderadamente diferenciado o mais frequente grau de diferenciação. A quimioterapia associada à radioterapia foi instituída em 81,9% dos pacientes, sendo necessária a cirurgia de amputação abdominoperineal como terapia de resgate em 18,2% dos pacientes

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anus neoplasm: study of a case series

Fernandes¹,

Santana²,

Júnior³

et al. 2011

J. Coloproctol. (Rio J.)

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Prevalence of anal cytological abnormalities in women with positive cervical cytology

Calore

Giaccio

Nadal

2011

Diagnostic Cytopathology

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The objective of this study was to estimate the prevalence of cytological abnormalities of the anal mucosa in women with positive cervical cytology, but without macroscopic anal lesion. Ultimately we postulated if the anal mucosa may be a reservoir of HPV, which would allow the reinfection of cervix. Forty-nine patients with abnormal cervical cytology were selected for this work. In a period not exceeding one week of collecting cervix cytology, two swab specimens of the anal canal were also collected. Women diagnosed with cervical HSIL by Pap smear were referred for colposcopy with biopsy of the lesions, to confirm the cytologic diagnosis and ablation of the lesion. We demonstrated a high prevalence of anal squamous intraepithelial lesions in patients with cervical squamous intraepithelial lesions (29 of the total of 49 patients = 59.2%). Of the 20 cases of cervical LSIL, 11 (55%) had abnormal anal cytology. Of the 26 cases with cervical HSIL, 16 (61.5%) had abnormal anal cytology. So, there was a discrete higher prevalence of abnormal anal cytology in cases of high-grade cervical squamous lesions (cervical HSIL). These results help to support the hypothesis that the anal mucosa is a reservoir of HPV, which can be a source of re-infection for the cervix. However, there was no significant association between the practice of anal sex and the prevalence of anal cytological abnormalities. These facts are epidemiologically important for future programs for population eradication of cervical lesions related to HPV. Diagn. Cytopathol. 2011;39:323-327. © 2010 Wiley-Liss, Inc.

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Clinicopathological aspects and prevalence of human papillomavirus in anal cancer

Aguiar

Bosso

Leal

et al. 2014

Journal of Coloproctology

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Anal cancer is relatively rare; however, its incidence has increased in recent years. Several risk factors are associated with the development of anal cancer, including age older than 50 years, low-fiber diet, chronic anal fistulas, smoking, multiple partners, anal intercourse practice, Human Immunodeficiency Virus infection and immunosuppression. However, the presence of human papillomavirus represents the main risk factor for the development of anal cancer. The aim of this study was to evaluate the clinicopathological aspects of a series of patients with anal carcinomas diagnosed in Hospital Araújo Jorge, Goiânia-Goiás, as well as the prevalence of human papillomavirus genome in these tumors. Clinical, pathological and socio-demographic data were collected from the respective medical files and paraffin blocks containing anal carcinomas specimens were used for DNA extraction and detection of human papillomavirus, by means of polymerase chain reaction, using short PCR fragment primers. Forty-three cases were selected and had the data analyzed, while 38 cases were tested for human papillomavirus genome detection. Among the evaluated patients, 62.8% were women; 53.4% of tumors were squamous cell carcinoma and 46.5% of the patients were aged between 60 and 75 years. Risk factors, such as smoking (39.5%) and alcoholism (20.9%) were recorded in the studied group. Lymph node metastases were detected in 30.2% of cases and 7.0% had distant metastasis. The detection of human papillomavirus DNA was positive in 76% of cases assessed and this was significantly associated with squamous cell carcinomas. Aggressive behavior and advanced stage of anal cancer described in this study highlight the need for preventive measures that contemplate these tumors, including vaccination against human papillomavirus.

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Estudo demográfico do câncer de canal anal e ânus no estado de Sergipe

Cited by 4 publications

References 8 publications

Anus neoplasm: study of a case series

Anus neoplasm: study of a case series

Prevalence of anal cytological abnormalities in women with positive cervical cytology

Clinicopathological aspects and prevalence of human papillomavirus in anal cancer

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