Anal cancer is relatively rare; however, its incidence has increased in recent years. Several risk factors are associated with the development of anal cancer, including age older than 50 years, low-fiber diet, chronic anal fistulas, smoking, multiple partners, anal intercourse practice, Human Immunodeficiency Virus infection and immunosuppression. However, the presence of human papillomavirus represents the main risk factor for the development of anal cancer. The aim of this study was to evaluate the clinicopathological aspects of a series of patients with anal carcinomas diagnosed in Hospital Araújo Jorge, Goiânia-Goiás, as well as the prevalence of human papillomavirus genome in these tumors. Clinical, pathological and socio-demographic data were collected from the respective medical files and paraffin blocks containing anal carcinomas specimens were used for DNA extraction and detection of human papillomavirus, by means of polymerase chain reaction, using short PCR fragment primers. Forty-three cases were selected and had the data analyzed, while 38 cases were tested for human papillomavirus genome detection. Among the evaluated patients, 62.8% were women; 53.4% of tumors were squamous cell carcinoma and 46.5% of the patients were aged between 60 and 75 years. Risk factors, such as smoking (39.5%) and alcoholism (20.9%) were recorded in the studied group. Lymph node metastases were detected in 30.2% of cases and 7.0% had distant metastasis. The detection of human papillomavirus DNA was positive in 76% of cases assessed and this was significantly associated with squamous cell carcinomas. Aggressive behavior and advanced stage of anal cancer described in this study highlight the need for preventive measures that contemplate these tumors, including vaccination against human papillomavirus.

Estudos recentes abordaram a importância do exame de tomografia computadorizada (TC) de tórax em pacientes com COVID-19 com resultados de RT-PCR falso negativos e relataram a sensibilidade da TC de tórax em torno de 98% dos casos. Assim, de acordo com o protocolo oficial de diagnóstico e tratamento (6ª edição) declarado pela Comissão Nacional de Saúde da China, o exame de tomografia computadorizada é de grande importância não apenas no diagnóstico de COVID-19, mas também no monitoramento da progressão da doença e avaliação da eficácia terapêutica. Assim, o objetivo deste trabalho é reforçar a importância do acompanhamento e realização de exames de imagem, como a TC de tórax, em pacientes com clínica sugestiva ou confirmatória de COVID-19, como o caso em questão, com o intuito de diagnosticar corretamente estes pacientes e, a partir disso, oferecer o suporte médico necessário.Descritores: COVID-19, Testes Moleculares, Tomografia Computadorizada de Tórax. COVID-19 with negative molecular testes: a case reportAbstract: Recent studies have addressed the importance of chest computed tomography (CT) examination in patients with COVID-19 with false negative RT-PCR results and reported chest CT sensitivity in around 98% of cases. Thus, according to the official diagnosis and treatment protocol (6th edition) declared by the National Health Commission of China, the CT scan is of great importance not only in the diagnosis of COVID-19, but also in monitoring the progression of the disease and evaluation of therapeutic efficacy. Thus, the objective of this study is to reinforce the importance of monitoring and performing imaging tests, such as chest CT, in patients with suggestive or confirmatory clinical features of COVID-19, as in the case in question, in order to correctly diagnose these patients and, based on that, offer the necessary medical support.Descriptors: COVID-19, Molecular Tests, Chest Computed Tomography. COVID-19 com pruebas moleculares negativas: reporte de um casoResumen: Estudios recientes han abordado la importancia del examen de tomografía computarizada (TC) de tórax en pacientes con COVID-19 con resultados de RT-PCR falsos negativos y la sensibilidad de la TC de tórax informada en alrededor del 98% de los casos. Así, según el protocolo oficial de diagnóstico y tratamiento (6a edición) declarado por la Comisión Nacional de Salud de China, la tomografía computarizada es de gran importancia no solo en el diagnóstico de COVID-19, sino también en el seguimiento de la progresión de la enfermedad y evaluación de la eficacia terapéutica. Así, el objetivo de este estudio es reforzar la importancia del seguimiento y realización de pruebas de imagen, como la TC de tórax, en pacientes con clínica sugestiva o confirmatoria de COVID-19, como en el caso en cuestión, para diagnosticar correctamente estos. pacientes y, en base a ello, ofrecer el apoyo médico necesario.Descriptores: COVID-19, Pruebas Moleculares, Tomografía Computarizada de Tórax.