Enriquecimento ambiental como estratégia para promover a neurogênese na doença de Alzheimer: possível participação da fosfolipase A2

Schaeffer, Evelin L.

doi:10.1590/s0101-60832010000200008

Cited by 3 publications

(6 citation statements)

References 102 publications

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“…Brain plasticity is dependent on sensory experiences lived throughout life and can be enhanced by several factors. Studies such as that of Schaeffer (2010) indicate that non-pharmacological intervention, such as environmental enrichment, may be an appropriate strategy for the promotion of endogenous neurogenesis, thus improving cognitive and behavioral function.…”

Section: Resultsmentioning

confidence: 99%

“…Studies not only show that our brain increases the population of neurons after certain stimuli (Schaeffer, 2010) but also indicate that, if the stimuli do not become habits, therefore repeated over time, around 99% of these new neurons tend to die for lack of stimuli, returning to previous brain performance.…”

Section: Neurogenesis and Neuroplasticitymentioning

confidence: 97%

“…The stimuli of an enriched environment are undoubtedly the external factors that can induce important adaptive behavioral changes, as they induce structural and functional changes at the brain level, quickly and effectively. These stimuli, which improve the environment, are potent agents of induction of biological factors relevant for cognitive and emotional gain, which neurogenesis-formation of new nerve cells-and brain neuroplasticity (Schaeffer, 2010) are part of.…”

Section: Environmental Enrichment What Is It?mentioning

confidence: 99%

“…The erroneous idea that new nerve cells are not created after the embryonic development phase came to an end with the discovery of two important areas in the brain of adult mammals where neurogenesis occurs constitutively (Yamashima et al, 2007;Schaeffer, 2010). These areas, the sub-granular zone of the hippocampus and the subventricular zone of the lateral ventricles, are important neurogenic sites with good development potential even at more advanced ages of development.…”

Section: Neurogenesis and Neuroplasticitymentioning

confidence: 99%

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Environmental Enrichment as a Strategy to Confront Social Isolation Under the COVID-19 Pandemic

Davim

silva

Vieira

2021

Front. Behav. Neurosci.

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The moment of social isolation experienced by the world population due to the COVID-19 pandemic tends to trigger behavioral changes of different orders and on an exponential scale, regardless of social class, age, gender, or ethnicity. Environmental enrichment presents itself as an important strategy to face the social isolation imposed by the pandemic, in order to act as an important agent of induction of biological factors for cognitive and emotional development, favoring a better possibility of adaptation to isolation.

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Section: Resultsmentioning

confidence: 99%

Section: Neurogenesis and Neuroplasticitymentioning

confidence: 97%

Section: Environmental Enrichment What Is It?mentioning

confidence: 99%

Section: Neurogenesis and Neuroplasticitymentioning

confidence: 99%

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Environmental Enrichment as a Strategy to Confront Social Isolation Under the COVID-19 Pandemic

Davim

silva

Vieira

2021

Front. Behav. Neurosci.

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“…Recent studies reveal that a space enriched with toys, tunnels and physical activities 5 significantly stimulates the neurogenesis 6 of rodents. This improves the ability to perform cognitive tasks 5 , due to increased exploration activity and new sensory experiences, thus increasing AW.…”

mentioning

confidence: 99%

Enriquecimento ambiental como princípio ético nas pesquisas com animais

et al. 2016

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Animals used in experiments have reduced levels of welfare and are thus vulnerable to pain and suffering. Considering that environmental enrichment increases the quality of life of captive animals, we aimed to assess its scientific application regarding the promotion of animal welfare by recognizing the vulnerability of biological models. Documentary analysis and experimental tests were conducted, stating that despite this technique having been applied mainly in neuroscience studies, endorsing their feasibility and the improvement in learning, the rationale for its use has been limited to the successful development of research, that is, not in recognition of animals' vulnerability, their need for welfare and quality of life. In contrast, we proposed the application of environmental enrichment for laboratory animals, within a framework of scientific contractualism and the researcher's responsibility, as a standard to be adopted for the mutual benefit of scientific development and the quality of animal life. Keywords: Bioethics. Bioethics-Enviromental. Animal Experimentation. Scientific misconduct. Psychology Experimental. Resumo Enriquecimento ambiental como princípio ético nas pesquisas com animaisAnimais utilizados em experimentos dispõem de reduzidos meios de bem-estar, estando vulneráveis a dor e sofrimento. Considerando que a técnica de enriquecimento ambiental aumenta a qualidade de vida de animais cativos, objetivou-se avaliar sua aplicação científica no âmbito da promoção de bem-estar por meio do reconhecimento da vulnerabilidade de modelos biológicos. Para tanto, conduziram-se análises documentais e ensaios experimentais, atestando que apesar de a técnica de enriquecimento ambiental ter sido aplicada principalmente em estudos de neurociência, endossando sua viabilidade, e da melhora no aprendizado, a justificativa para sua utilização tem se limitado ao bom desenvolvimento da pesquisa, e não em reconhecimento da vulnerabilidade e necessidade de bem-estar e qualidade de vida do animal. Em contraponto, foi proposta a aplicação do enriquecimento ambiental em animais de laboratório, num âmbito de contratualismo científico e responsabilidade do pesquisador, como norma a ser adotada para benefício mútuo do desenvolvimento científico e qualidade de vida animal. Palavras-chave: Bioética. Bioética-Meio ambiente. Experimentação animal. Má conduta científica. Psicologia experimental. ResumenEl enriquecimiento ambiental como un principio ético en la investigación con animales Los animales utilizados en experimentos disponen de bienestar reducido y están expuestos al dolor y al sufrimiento. Considerando que la técnica de enriquecimiento ambiental aumenta la calidad de vida de los animales en cautiverio, el objetivo de este estudio fue evaluar su aplicación científica en el ámbito de la promoción del bienestar mediante el reconocimiento de la vulnerabilidad de los modelos biológicos. Para ello, se realizaron análisis documentales y ensayos experimentales, señalando que a pesar de que la técnica de enriquecimien...

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Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

Schaeffer

Silva

Novaes

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Enriquecimento ambiental como estratégia para promover a neurogênese na doença de Alzheimer: possível participação da fosfolipase A2

Cited by 3 publications

References 102 publications

Environmental Enrichment as a Strategy to Confront Social Isolation Under the COVID-19 Pandemic

Environmental Enrichment as a Strategy to Confront Social Isolation Under the COVID-19 Pandemic

Enriquecimento ambiental como princípio ético nas pesquisas com animais

Differential roles of phospholipases A2 in neuronal death and neurogenesis: Implications for Alzheimer disease

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