Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming

Cleto, Lorena Sabino; Oleto, A.F.; Sousa, Lirlândia P.; Barreto, T.O.; Cruz, Jáder Santos; Penaforte, C.L.; Magalhães, José Carlos de; Sousa-Franco, J.; Pinto, Kelerson M. C.; Campi-Azevedo, Ana Carolina; Rocha‐Vieira, Etel

doi:10.1590/s0100-879x2011007500050

Cited by 15 publications

(16 citation statements)

References 37 publications

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“…If we exclude the possibility of cytokine release from skeletal muscles [2] intensively contracting during fi xation, the high blood levels of IL-6 and IL-1α in mice with normal heart rhythm can be regarded as an indicator of a latent infl ammatory focus that had no electrocardiographic and clinical manifestations. In that case, mice with bradyarrhythmia are at another/next stage of the pathological process in the heart characterized by aggravation of heart failure due to either hemodynamic shifts caused by reduced HR and heart rhythm irregularities or due to impaired morphogenetic (reparative) function of the immune system.…”

Section: Resultsmentioning

confidence: 99%

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

et al. 2012

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Differences in the pools of 10 cytokine were found in blood samples from the caudal vein of mice with normal and abnormal heart rhythm. Both groups were albino mice bred by us and differing from mdx albino mice by the absence of mutation in muscular dystrophin gene. Mice with normal heart rhythm had low IL-17 content and elevated concentrations of proinflammatory cytokines IL-6 and IL-1α in comparison with the normal (according to published data). In mice with bradyarrhythmias, increased blood levels of IL-10, IL-6, IL-5, IL-2, IL-1α, IL-17, IL-4, TNF-α, and granulocyte-macrophage colony-stimulating factor were detected. The relative content of IL-4 and IL-17 in the total cytokine pool increased. The lifespan of mice with bradyarrhythmias and cytokine hyperexpression was shorter by 2-3 months in comparison with mice without heart rhythm disturbances and moderate changes in the cytokine pool.

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Section: Resultsmentioning

confidence: 99%

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

et al. 2012

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“…Cleto et al 37 studied the activation of lipid peroxidation and nuclear factor-κB (NF-κB) in skeletal muscle, and the plasma cytokine profile following maximum progressive swimming in 15 adult male Swiss mice divided into three groups: immediately after exercise (EX1), 3 h after exercise (EX2) and control. Exercising mice swam until exhaustion.…”

Section: Resultsmentioning

confidence: 99%

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Gomes¹,

Rocha-e-Silva²

2012

Acta ortop. bras.

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To review recently published papers in the Brazilian Scientific press on the general subject of physical exercise. All articles published in 2010/2011 found through the keyword exercise were collected from 11 Brazilian Journals. They were hand filtered to exclude all but original research papers. They were grouped according to subject categories and subcategories. A brief summary of all included articles was produced, comparing similar articles between them. The most commonly found interactions refer to exercise vs. the cardiovascular system, metabolism and the locomotor system, in this order. The volume of scientific research in the field is high and of sufficient quality to justify highlighting.

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“…Exercise induces transitory alterations in the serum/plasma cytokine profile that involve mainly an increase in serum levels of interleukin-6 (IL-6) (Oleto et al ., 2011). Although we did not quantify circulating IL-6 levels, the significant reductions in CK and AST seen in individuals heterozygous for IL-6 and the non-significant reduction in these parameters observed for the other genotypes in the before-after comparison of pequi-oil suggested a better response to this antioxidant supplementation against exercise-induced damage in the GC genotype.…”

Section: Discussionmentioning

confidence: 99%

“…Strenuous exercise not only induces lipid peroxidation, but also promotes inflammation, changes in the immune cell count and the release of acute phase proteins such as C-reactive protein (CRP) (Oleto et al ., 2011; Miranda-Vilela et al ., 2009a, 2012; Miranda-Vilela, 2012). The synthesis of CRP is, in turn, regulated by cytokines, mostly IL-6 (Moleres et al ., 2009); chronically elevated levels of IL-6 are associated with vascular smooth muscle growth, increased production of acute phase protein and effects on lipid and lipoprotein metabolism, all of which can contribute to an increased risk of CVD (Shen et al ., 2008; Gan et al ., 2013).…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

2016

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Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations.

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Plasma cytokine response, lipid peroxidation and NF-κB activation in skeletal muscle following maximum progressive swimming

Cited by 15 publications

References 37 publications

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

Cytokine profile of the blood in mice with normal and abnormal heart rhythm

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

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