Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

Rudge, Marilza Vieira Cunha; Damasceno, Débora Cristina; Volpato, Gustavo Tadeu; Almeida, F. C. G.; Calderon, Iracema de Mattos Paranhos; Lemonica, I. P.

doi:10.1590/s0100-879x2006005000132

Cited by 52 publications

(26 citation statements)

References 15 publications

(13 reference statements)

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“…However, this increase in placental weight was not sufficient to reverse the clinical picture of RCIU. These results corroborate studies of other authors (40).…”

Section: Discussionsupporting

confidence: 94%

Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

Spadotto

Damasceno

Godinho

et al. 2012

Arq Bras Endocrinol Metab

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Objectives: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. Materials and methods: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. Results: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. Conclusions: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively. Arq Bras Endocrinol Metab. 2012;56(2):96-103 Keywords Sexual behavior; physical development; diabetes; female reproductive physiology; female rat; streptozotocin RESUMO Objetivos: O objetivo deste estudo foi avaliar o desenvolvimento físico e sexual e a fisiologia reprodutiva de ratas que se desenvolveram em condições hiperglicêmicas in utero e lactação. Materiais e métodos: Para induzir o diabetes nas ratas, foi utilizada estreptozotocina em dose única via intravenosa antes do acasalamento. A prole feminina foi avaliada por meio dos seguintes parâmetros: o desenvolvimento físico; a idade de abertura vaginal e do primeiro estro, peso e avaliação histológica do útero e ovários; a duração do ciclo estral, o comportamento sexual e a fertilidade após acasalamentos naturais. Resultados: O diabetes materno provocou, na prole feminina, retardo no desenvolvimento físico; diminuição do peso dos ovários e do número de folículos; a performance reprodutiva foi inferior à do grupo controle. Conclusões: Concluiu-se que a exposição aos meios intrauterino e lactacional hiperglicêmicos provocou retardo no desenvolvimento físico e sexual e prejudicou a fisiologia reprodutiva de ratas. Arq Bras Endocrinol Metab. 2012;56(2):96-103

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“…However, this increase in placental weight was not sufficient to reverse the clinical picture of RCIU. These results corroborate studies of other authors (40).…”

Section: Discussionsupporting

confidence: 94%

Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

Spadotto

Damasceno

Godinho

et al. 2012

Arq Bras Endocrinol Metab

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“…Calderon, et al, 2007;. The observed reduced body weights may be due to the metabolic alterations caused by hyperglycemia (Damasceno, Volpato, Calderon, Aguilar, & Rudge, 2004).…”

Section: Discussionmentioning

confidence: 97%

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Mohammed

Okail

Ibrahim

et al. 2018

JoBAZ

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Background: Phytotherapeutic treatment is used in the treatment of diabetes and its complications. The current study aims to evaluate the significant effect of supplementation of aqueous olive leaf extract (OLE) (Olea europaea) in the kidney of diabetic pregnant mice and their fetuses. Forty pregnant mice were divided into four groups contained 10 mice each after mating. The first group was the control (G1). The second group (GII) was intraperitoneally injected by a single dose of (240 mg/kg body weight) of streptozotocin (STZ). The third group (GIII) was administrated with a daily oral dose of extract of olive leaf extract (100 mg/kg) from days 1 to 18 of gestation. The fourth group (GIV) was injected intraperitoneally by a single dose of (240 mg/kg body weight) of STZ and post-treatment with oral dose of extract of olive leaves from days 1 to day 18 of gestation. Results: Both mothers and their fetuses of STZ-induced diabetic group showed a decrease in weight compared to control and diabetic group supplemented OLE extract. According to the biochemical and histopathological observations, the STZ-induced diabetic group showed a significant (P < 0.05) increase in serum urea and creatinine levels parallel with detectable histopathological changes in kidney tissues of pregnant mice and their fetuses. Moreover, there was a significant decrease in serum urea and creatinine (P < 0.05) of diabetic mother group under treatment with OLE as compared to diabetic mice. Also, histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosis in pregnant mice and their fetuses when compared with control group. Also, there was an increase in the anti-angiotensin II (Ang II) immunoreactivity in renal tubules, intraglomerular, and interstitial cells in the kidney tissue of STZ-induced diabetic group which was markedly improved by treatment with OLE.

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“…However, several plants had already been studied during pregnancy, and showed no deleterious effects (Monteiro et al 2001, Rudge et al 2007, Volpato et al 2011.…”

Section: Introductionmentioning

confidence: 99%

Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

Volpato

Francia-Farje

Damasceno

et al. 2015

An. Acad. Bras. Ciênc.

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Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid uterus was weighed with its contents and the fetuses were analyzed. Results showed that the treated group with 500 mg/kg presented decreased placental weights and placental index, although the treatment with bitter orange essential oil did not show any alteration in maternal reproductive performance, toxicological effect, changes in ossification sites, and malformation index. In conclusion, the treatment of Citrus aurantium essential oil was not teratogenic and did not alter the maternal reproductive outcome.

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Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats

Cited by 52 publications

References 15 publications

Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats

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