Role of matrix metalloproteinases in the development of airway inflammation and remodeling

Lagente, Vincent; Manoury, Boris; Nénan, Soazig; Quément, Catherine Le; Martin-Chouly, Corinne; Boichot, Elisabeth

doi:10.1590/s0100-879x2005001000009

Cited by 143 publications

(97 citation statements)

References 52 publications

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“…However, this decrease must not be attributed to a direct effect of siMMP12 on MMP-2 mRNA. MMP-12 has the capacity to activate pro-MMP-2, as described before, and MMP-2 is also involved in fibrosis [149] and particularly in pulmonary fibrosis even if its role remains unclear [31] but nothing is currently known about the influence of MMP-12 on MMP-2 transcription.…”

Section: Mmp-12 Silencingmentioning

confidence: 84%

See 1 more Smart Citation

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Garbacki¹,

Valentin²,

Piette³

et al. 2009

Pulmonary Pharmacology & Therapeutics

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Section: Mmp-12 Silencingmentioning

confidence: 84%

“…Human MMP-12 is translated as a 1.8 kb transcript encoding a 470 amino acid proenzyme that is 64% identical to the mouse protein [31]. Its molecular mass is 54 kDa and comprises three domains (Fig.…”

Section: Brief Overview Of Mmp-1structure and Functionmentioning

confidence: 99%

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Garbacki¹,

Valentin²,

Piette³

et al. 2009

Pulmonary Pharmacology & Therapeutics

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“…Through degeneration of extracellular matrix proteins, MMPs are implicated in the development of tissue fibrosis, damage, and inflammation (Chakrabarti & Patel, 2005;Corbel et al, 2002;Lagente et al, 2005). MMP9 appears to serve as a key target for SM.…”

Section: Discussionmentioning

confidence: 99%

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

Panahi¹,

Ghanei²,

Vahedi³

et al. 2013

Journal of Immunotoxicology

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Pulmonary problems are among the most common chronic complications of sulfur mustard (SM) intoxication and adversely affect patients' quality-of-life. The present trial investigated the impact of immunotherapy with interferon (IFN)-g on quality-of-life, respiratory symptoms, and circulating immunologic and oxidative parameters in patients suffering from chronic SMinduced complications. Patients (n ¼ 15) were administered IFNg (100 mg) every other day for a period of 6 months. Assessment of quality-of-life [using St. George respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT) indices], the severity and frequency of respiratory symptoms, and serum levels of immunologic [including interleukin (IL)-2, IL-4, IL-6, IL-10, IFNg, calcitonin gene related peptide (CGRP), matrix metallopeptidase (MMP)-9, and tumor necrosis factor (TNF)-a], oxidative stress [malondialdehyde (MDA) as well as total and reduced glutathione, and catalase and superoxide dismutase (SOD) activity], and fibrogenic [transforming growth factor (TGF)-b] parameters were performed at baseline and at trial end. The results indicated that IFNg therapy is associated with improvements in SGRQ (p50.001) and CAT (p50.001) scores, decreased severity of cough (p ¼ 0.001), dyspnea (p50.001), and morning dyspnea (p50.001), reduced frequency of sputum production (p50.001) and hemoptysis (p50.001), and elevated FEV 1 (p ¼ 0.065). Serum levels of IL-4 (p50.001), IL-6 (p50.001), IL-10 (p50.001), CGRP (p50.001), MMP-9 (p ¼ 0.001), TNFa (p50.001), TGFb (p50.001) and MDA (p ¼ 0.001) were decreased while those of IL-2 (p50.001), IFNg (p50.001), and both total (p ¼ 0.005) and reduced glutathione (p ¼ 0.061) increased by the end of the trial. It was concluded that IFNg has favorable effects on the quality-of-life and alleviates respiratory symptoms in patients suffering from chronic SM-induced pulmonary complications. A modulation of cytokines and oxidative stress appears responsible for the clinical efficacy of IFNg.

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“…To understand the biology of MMPs in a variety of relevant human pathological conditions such as allergic inflammation, tissue injury and repair, remodeling, and host defense against pathogens. 3,4,5 At least eight of the known human MMP genes (MMP-1, -3, -7, -8, -10, -12, -13 and -20) are clustered on chromosome 11 at 11q21-23. Other MMP genes are scattered among chromosomes 1, 8, 12, 14, 16, 20, and 22.…”

Section: Introductionmentioning

confidence: 99%

A study on the correlation of matrix metalloproteinase MMP1 in COPD and smoking in the North Indian population

et al. 2017

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Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway obstruction and destruction of lung tissue, the disease for which at present there is no cure, although the treatment can slow worsening. Nearly 90% of COPD is caused by long term cigarette smoking; however, only 25% of chronic tobacco smokers develop COPD, the exact cause of this predisposition of some smokers to acquire COPD is still poorly understood at the molecular level. Lot of studies are available showing the correlation of MMP1 and asthma but not much work has been done on its correlation with COPD especially in North India. The outcome of our study was also expected to discover MMP1 as a new target for treating COPD and its progression in smokers. Aims and Objectives: The association of COPD and smoking with MMP1 gene product and SNP in the North Indian population was intended to be studied. Material and Methods:The proposed study was a case control study. In this study adults aged 30 years and above fulfilling the inclusion criteria (the criteria mentioned under the materials and methods) were considered and a total of 180 subjects were taken after determining the sample size. Pulmonary function test (PFT) was performed by Spirometry. Three main groups each consisting of 60 subjects were formed on the basis of smoking history and Spirometry: Ist group: Smokers without co-morbidity with normal PFT, IInd group: Smokers with Spirometry proved COPD and without any other co-morbidity, IIIrd group: Healthy Non-smoker controls. Quantification of metalloproteinase MMP1 in all the groups were performed in the serum with ELISA kits and Single Nucleotide Polymorphism (SNP 1G-1607 2G, ID rs1799750) studiesin the gene encoding MMP1 linked to COPD susceptibility in smokers was performed by DNA Sequencing Analysis. The correlation between the SNPs, gene product, smokingand COPD was studied. Results: MMP1 concentration was seen increased in serum of COPD and smokers when compared to healthy controls. And there is high negative correlation between *FEV1/FVC % (post-bronchodilator)and MMP1 in COPD compared to Smokers and Healthy Controls. However, from the results of present analysis, we could show negative correlation between MMP1 and *FEV1/FVC % in all the 3 groups but the correlation proves to be much more negative in Group II i.e. Smokers with COPD. Statistically Significant Positive Correlation of Pack Years with MMP1 conc., and Statistically Significant Negative Correlation between Pack Years and *FEV1/FVC % was seen. Conclusion: In conclusion, our present analyses did show significant association between MMP1 and COPD risk in North Indian population. MMP1 levels of COPD patients were significantly increased in smokers and may contribute to or be a marker of the pathophysiology of COPD.

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Role of matrix metalloproteinases in the development of airway inflammation and remodeling

Abstract: Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate extracellular matrix (ECM) turnover and

Cited by 143 publications

References 52 publications

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

A study on the correlation of matrix metalloproteinase MMP1 in COPD and smoking in the North Indian population

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