Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Garbacki, Nancy; Valentin, Emmanuel Di; Piette, Jacques; Cataldo, Didier; Crahay, Céline; Colige, Alain

doi:10.1016/j.pupt.2009.03.001

Cited by 38 publications

(26 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alveolar macrophages are the principal source of MMP-12 in the lung, and MMP-12 protein levels and enzymatic activity are increased in patients with chronic pulmonary pathologies and are inversely correlated with measures of lung function 31 32. Indeed, MMP-12 silencing has been proposed as a potential therapeutic approach to treat pathological lung tissue remodelling 31. Interestingly, we observed increased MMP-12 expression in alveolar macrophages and pulmonary fibroblasts from patients with SSc.…”

Section: Discussionmentioning

confidence: 65%

“…MMP-12 has recently emerged as a critical player in chronic pulmonary pathologies characterised by intense tissue remodelling such as asthma, chronic obstructive pulmonary disease and pulmonary fibrosis 31. Alveolar macrophages are the principal source of MMP-12 in the lung, and MMP-12 protein levels and enzymatic activity are increased in patients with chronic pulmonary pathologies and are inversely correlated with measures of lung function 31 32. Indeed, MMP-12 silencing has been proposed as a potential therapeutic approach to treat pathological lung tissue remodelling 31.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

et al. 2012

View full text Add to dashboard Cite

show abstract

“…MMP-12, which is also called macrophage elastase, is thought to play important roles in airway inflammatory diseases such as COPD and asthma (13). Besides macrophages, it has also been reported that airway smooth muscle and bronchial epithelial cells are important sources of MMP-12, which is thought to be deeply associated with the remodeling of these airway structural cells in chronic airway inflammatory diseases (7,8).…”

Section: Discussionmentioning

confidence: 99%

Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line

Yu¹,

Chiba²,

Sakai³

et al. 2010

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. Matrix metalloproteinase-12 (MMP-12) has been suggested to play an important role in airway inflammatory diseases. Tumor necrosis factor-α (TNF-α ) is known to cause an upregulation of MMP-12 via an activation of activator protein-1 (AP-1) in monocytes. In the present study, we investigated the effect of TNF-α on the expressions of MMP-12 in airway epithelial cells, one of the sources of MMP-12 in the airway, and its underlying mechanism. MMP-12 mRNA and protein expressions induced by TNF-α in the absence or presence of BMS-345541 (a selective I κ B kinase inhibitor) or SP600125 [a selective c-Jun N-terminal kinase (JNK) inhibitor] were measured by quantitative real-time PCR and Western blotting, respectively. Furthermore, siRNAs for p65 and JNK2 were used to confirm the involvements of nuclear factor-κ B (NF-κ B) and AP-1 in the MMP-12 mRNA expression induced by TNF-α in A549 cells. Both MMP-12 mRNA and protein were upregulated by the treatment with TNF-α in time-and concentration-dependent manners. Both BMS-345541 and SP600125 inhibited the upregulation of MMP-12 induced by TNF-α . Furthermore, both the depletion of p65 and JNK2 by siRNAs significantly attenuated the upregulation of MMP-12 induced by TNF-α . These findings suggest that both NF-κ B and JNK / AP-1 pathways are important for the MMP-12 upregulation induced by TNF-α in A549 cells.Keywords: matrix metalloproteinase-12 (MMP-12), tumor necrosis factor-α (TNF-α ), nuclear factor-κ B (NF-κ B), activator protein-1 (AP-1)Full Paper

show abstract

“…This protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodeling of the extracellular matrix. It is also related to disorganization of lung parenchyma [43].…”

Section: Protein Diagnostic Biomarkers Detected In Nsclc Patients' Flmentioning

confidence: 99%

Proteomics biomarkers for non-small cell lung cancer

Kiśluk

Ciborowski

Niemira

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Cited by 38 publications

References 153 publications

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

Possible Involvements of Nuclear Factor-κB and Activator Protein-1 in the Tumor Necrosis Factor-α–Induced Upregulation of Matrix Metalloproteinase-12 in Human Alveolar Epithelial A549 Cell Line

Proteomics biomarkers for non-small cell lung cancer

Contact Info

Product

Resources

About