Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001

Neto, Roberto da Justa Pires; Lima, Danielle Malta; Paula, Sérgio Oliveira de; Lima, C.M.; Rocco, Iray Maria; Fonseca, Benedito Antônio Lopes da

doi:10.1590/s0100-879x2005000600005

Cited by 19 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[51][52][53] It seems that the same genotypes have been circulating all over the country during the last two decades, with little genetic variation in the virus population. 54,55 Thus, the variance related to differences in the virulence of circulating viral strains are likely to be minimal, and we can infer that the clinical differences seen in this cohort are likely related to host and epidemiologic factors.…”

Section: Discussionmentioning

confidence: 89%

Characterization of a Dengue Patient Cohort in Recife, Brazil

Cordeiro¹,

Silva²,

Brito³

et al. 2007

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

From 2004 to 2006, 658 patients with suspected dengue virus infections were enrolled in a clinical dengue cohort established in Recife, Pernambuco, located at the northeastern region of Brazil. A total of 2,364 blood samples were collected, and serum, plasma, and cells were cryopreserved. Among the suspected cases, 354 (54%) were confirmed as acute DENV-3 infection based on reverse transcription-polymerase chain reaction, virus isolation, and ELISA-IgM. According to WHO criteria, 29.4% of the positive acute cases were classified as dengue fever (DF) and 8.2% of the cases as dengue hemorrhagic fever (DHF), grade 1 or 2. The DHF cases represent 100% of those confirmed in Recife during the period of the study. The dengue cases that did not fulfill the definition of either DHF or DF were classified as DF complicated and accounted for 44.0% of the cases. All the acute cases were classified as either primary or secondary acute dengue virus infections. Secondary infection was predominant in patients with DF; however, there was no predominance of either primary or secondary infections in patients with DHF.

show abstract

Section: Discussionmentioning

confidence: 89%

Characterization of a Dengue Patient Cohort in Recife, Brazil

Cordeiro¹,

Silva²,

Brito³

et al. 2007

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Interestingly, we observed no DHF cases associated with DENV-3, as has been shown in epidemiological studies in Mexico [ 39 ]. Recently, DENV-3 has been isolated in Brazil but its association with DHF has not been clearly established [ 40 ]. In contrast, DENV-3 was associated with DHF in an outbreak in Cuba [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico

et al. 2008

View full text Add to dashboard Cite

Background: Dengue (DEN) is an infectious disease caused by the DEN virus (DENV), which belongs to the Flavivirus genus in the family Flaviviridae. It has a (+) sense RNA genome and is mainly transmitted to humans by the vector mosquito Aedes aegypti. Dengue fever (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4). Epidemiological and evolutionary studies have indicated that host and viral factors are involved in determining disease outcome and have proved the importance of viral genotype in causing severe epidemics. Host immune status and mosquito vectorial capacity are also important influences on the severity of infection. Therefore, an understanding of the relationship between virus variants with altered amino acids and high pathogenicity will provide more information on the molecular epidemiology of DEN. Accordingly, knowledge of the DENV serotypes and genotypes circulating in the latest DEN outbreaks around the world, including Mexico, will contribute to understanding DEN infections.

show abstract

“…All four serotypes are currently hyperendemic in Brazil. DENV serotypes 1, 2 and 3 have been circulating in Brazil for at least two decades [12] ; DENV serotype 4 has been circulating since at least 2010 [13] .…”

Section: Introductionmentioning

confidence: 99%

Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1–3 in Brazil

et al. 2014

View full text Add to dashboard Cite

Dengue virus and its four serotypes (DENV-1 to DENV-4) infect 390 million people and are implicated in at least 25,000 deaths annually, with the largest disease burden in tropical and subtropical regions. We investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. For all three serotypes, we estimated that the introduction of new lineages occurred within 7 to 10-year intervals. New lineages were most likely to be imported from the Caribbean region to the North and Northeast regions of Brazil, and then to disperse at a rate of approximately 0.5 km/day. Joint statistical analysis of evolutionary, epidemiological and ecological data indicates that aerial transportation of humans and/or vector mosquitoes, rather than Aedes aegypti infestation rates or geographical distances, determine dengue virus spread in Brazil.

show abstract

Molecular epidemiology of type 1 and 2 dengue viruses in Brazil from 1988 to 2001

Abstract: Dengue is a mosquito-borne viral infection that in recent decades has become a major international public health concern. Epidemic dengue fever reemerged in Brazil in 1981. Since 1990 more than one dengue virus serotype has been circulating in this tropical country and increas-

Cited by 19 publications

References 37 publications

Characterization of a Dengue Patient Cohort in Recife, Brazil

Characterization of a Dengue Patient Cohort in Recife, Brazil

Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico

Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1–3 in Brazil

Contact Info

Product

Resources

About