Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico

Gardella-Garcia, Catalina E; Pérez-Ramírez, Gerardo; Navarrete-Espinosa, Joel; Cisneros, Alejandro; Jiménez-Rojas, F.; Ramírez-Palacios, Luis Román; Rosado-Leon, Rocio; Camacho-Nuez, Minerva; Muñoz, Marı́a de Lourdes

doi:10.1186/1471-2180-8-117

Cited by 15 publications

(21 citation statements)

References 46 publications

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“…It is well accepted that immunity to a particular infectious disease governs the development of the severe form of the disease and the rapidity of its development to some extent. Host factors, such as age, nutritional state and HLA type, and vectorial factors, such as viral genotype, can also play a role in deciding the severity of disease 7,15 . Immune modulations of pregnancy are likely to contribute.…”

Section: Discussionmentioning

confidence: 99%

“…Host factors, such as age, nutritional state and HLA type, and vectorial factors, such as viral genotype, can also play a role in deciding the severity of disease. 7,15 Immune modulations of pregnancy are likely to contribute. Although the particular patient described by Berrington et al was born in Puerto Rico, she lived in Washington and her level of immunity to the infection was uncertain.…”

Section: Discussionmentioning

confidence: 99%

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Acute acalculous cholecystitis due to dengue hemorrhagic fever during pregnancy

Marasinghe

Sriyasinghe

Wijewantha

et al. 2011

J of Obstet and Gynaecol

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A 29-year-old pregnant woman presented with fever, right hypochondrial pain and fatigability at 29 weeks of gestation. Dengue hemorrhagic fever was diagnosed based on clinical, hematological and serological features. However, ultrasound scanning was suggestive of acute acalculous cholecystitis. The patient was managed symptomatically and made a good recovery 8 days following onset of fever. This is the first case of acute acalculous cholecystitis coinciding with dengue hemorrhagic fever reported during pregnancy from an endemic country in Asia. The possible viral and host factors for the development of such a severe form of disease and preventive measures are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acute acalculous cholecystitis due to dengue hemorrhagic fever during pregnancy

Marasinghe

Sriyasinghe

Wijewantha

et al. 2011

J of Obstet and Gynaecol

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“…The circulation of different serotypes and genotypes of DENV in a particular geographical region and the coexistence of two different serotypes or genotypes in a given mosquito or patient have been broadly documented [138,139,142]. Another study performed in 2007 showed that regions of the E gene underwent recombination in a patient harboring a mixed infection of DENV-1 [139].…”

Section: Dengue Virusmentioning

confidence: 99%

Arboviruses: Variations on an Ancient Theme

et al. 2014

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Arboviruses utilize different strategies to complete their transmission cycle between vertebrate and invertebrate hosts. Most possess an RNA genome coupled with an RNA polymerase lacking proofreading activity and generate large populations of genetically distinct variants, permitting rapid adaptation to environmental changes. With mutation rates of between 10 -6 and 10 -4 substitutions per nucleotide, arboviral genomes rapidly acquire mutations that can lead to viral emergence. Arboviruses can be described in seven families, four of which have medical importance: Togaviridae, Flaviviridae, Bunyaviridae and Reoviridae. The Togaviridae and Flaviviridae both have ssRNA genomes, while the Bunyaviridae and Reoviridae possess segmented RNA genomes. Recent epidemics caused by these arboviruses have been associated with specific mutations leading to enhanced host ranges, vector shifts and virulence. KEYWORDS Arboviruses: the role of RNA genomes in viral adaptation & emergenceThe recent emergence of many arboviruses (i.e., West Nile virus [WNV] in North America [1] and Chikungunya virus [CHIKV] in the Indian Ocean islands [2]) serves as a reminder that these viruses are capable of rapidly adapting to changes in their environment. Such viral epidemics can often be associated with the accumulation of one or more specific mutations in the viral genome and highlight a hallmark feature of arboviruses [3][4][5][6]. Indeed, arboviruses, and many other RNA viruses, employ a unique feature of their RNA-dependent RNA polymerases in order to achieve this rapid adaptation: inaccuracy due to a lack of proofreading activity [7][8][9]. This inaccuracy is the result of evolutionary pressure related to the fidelity of the polymerase. Mutations that decrease the fidelity of viral polymerases, have been shown to cause the accumulation of attenuating and lethal mutations [10], while mutations that enhance the fidelity of the polymerase are also associated with attenuation due to a reduction in the number of viral quasispecies, leaving the virus unable to cope with sudden environmental changes within the host [11]. These studies and others have shown that RNA virus replication balances on a 'knife's edge', with slight changes in their fidelity leading to population collapse [12]. Arboviruses are further constrained by the need to replicate in both a vector and a host species. These two very dissimilar organisms each place unique selective pressures on the arboviral genome, such that mutations that adapt the virus to favor one host are often deleterious in the other host [13][14][15]. Despite this evolutionary pressure, many arboviruses have expanded both their geographical distribution and host range through the generation and accumulation of beneficial mutations [16,17].The major source of these mutations comes from errors that occur during genome replication. Mutation rates during viral RNA replication are in the range of 10 -6 -10 -4 substitutions per For reprint orders, please contact: reprints@futuremedicine.com

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“…These results, although valuable as a global distribution overview, do not inform the geographic fine-mapping of dengue serotypes and genotypes which are etiologically dependent on climate and distinct viral evolution trajectories. Such microevolutionary patterns are more readily apparent in phylogeographic analyses (Cisneros et al, 2006;Gardella-Garcia et al, 2008;Pinheiro and Corber, 1997;Rico-Hesse et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological implications of the genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico

Hernández-García

Muñoz

David

et al. 2020

Infection, Genetics and Evolution

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Variation and clade shifts in dengue virus (DENV) genotypes are responsible for numerous dengue fever outbreaks throughout Latin America in the past decade. Molecular analyses of dengue serotypes have revealed extensive genetic diversification and the emergence of new genotypes in Brazil (DENV-4 genotype I) and elsewhere in tropical and subtropical America. The goal of the present study is to assess the extent to which the adventitious introduction of DENV genotypes and their increasing genetic diversity affects dengue epidemiology in Mexico. A nuanced sequence inspection and phylogenetic analysis of the C-prM nucleotide region of DENV was performed for specimens collecting in 2009 from the Veracruz State, Mexico. Findings were contrasted with specimens collected in adjacent years and analysed based on the epidemiological patterns reported between 1990 and 2019. Additionally, the identification process of various DENV genotypes was assessed, including: (1) DENV-1, genotype V, (2) the DENV-2 Asian/American and Asian II genotypes (3) DENV-3, genotype III, and (4) DENV-4, genotype I. This resulted in the discovery of a distinct genetic cladistic pattern for serotype DENV-2. Lastly, study findings suggest that a correlation exists between the emergence of novel genotypes and genetic diversification, with the increasing incidence of DENV infections in Mexico in 2009.

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Specific genetic markers for detecting subtypes of dengue virus serotype-2 in isolates from the states of Oaxaca and Veracruz, Mexico

Cited by 15 publications

References 46 publications

Acute acalculous cholecystitis due to dengue hemorrhagic fever during pregnancy

Acute acalculous cholecystitis due to dengue hemorrhagic fever during pregnancy

Arboviruses: Variations on an Ancient Theme

Epidemiological implications of the genetic diversification of dengue virus (DENV) serotypes and genotypes in Mexico

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