Lesões do sistema urinário em 1.063 cães

Abstract

Pesq. Vet. Bras. 32(8) The aim of this study was to determine the prevalence, epidemiology, clinical signiϐi-cance, and possible associated causes of the urinary system lesions in dogs necropsied between January 1999 and December 2010 at the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM). To accomplish this, the necropsy reports were analyzed retrospectively. In this time frame, 3,189 dogs were necropsied and about 30% had lesions in the urinary system. In most of the dogs (79.1%), lesions were single and in about 21% they were multiple, totalizing 1,373 lesions. Out of them, 1,014 (73.8%) were observed in the kidney and 359 (26.2%) were in the lower urinary tract (LUT). One third of the lesions in the urinary system were causes of spontaneous death or reason for euthanasia (SD/EUTH) of the affected dogs. The other two third of the lesions were considered incidental ϐindings. The main renal lesions diagnosed, in descending order of prevalence, were: tubulointerstitial nephritis, infarct, granulomatous nephritis (parasitary), glomerulonephritis, metastatic/multicentric neoplasms, pyelonephritis/pyelitis, and hydronephrosis. The main LUT lesions, in descending order of prevalence, were: cystitis, presence of viral inclusions bodies (morbillivirus), urolithiasis, urinary bladder dilatation, urinary bladder rupture (with uroperitoneum), and metastatic/multicentric neoplasms. Epidemiological aspects such as gender, breed, and age of affected dogs had expressive variations according to the type of lesion diagnosed. Uremia was observed in a signiϐicant number of cases of SD/EUTH and was mostly due to renal lesions.INDEX TERMS: Lesions of the urinary tract, diseases of dogs, pathology.

Epidemiologia e distribuição de lesões extrarrenais de uremia em 161 cães

“…Entretanto, quando analisados os cães com lesão no sistema urinário, essa prevalência é bem mais expressiva na rotina do laboratório (Inkelmann et al 2012). As lesões extrarrenais de uremia ocorrem especialmente em cães com insuficiência renal crônica (IRC) (Maxie & Newman, 2007), afetando principalmente cães de meia idade ou idosos (Polzin et al 1992), o que pode ser confirmado neste estudo.…”

“…A maioria das lesões que culminam em uremia são lesões renais e, dentre elas, a fibrose difusa, a glomerulonefrite e a nefrite túbulo-intersticial são as principais (Inkelmann et al 2012). Neste estudo, essas lesões estão entre as lesões mais prevalentes que resultaram em uremia, assim como a associação de duas ou mais lesões renais.…”

“…Considerando-se que, no período de 1999 a 2010, aproximadamente 33% dos cães necropsiados no LPV-UFSM apresentaram lesões no sistema urinário e que a uremia foi observada em um número expressivo de casos (Inkelmann et al 2012), os principais objetivos deste estudo retrospectivo foram determinar a epidemiologia e as características morfológicas, incluindo a localização das lesões extrarrenais de uremia, bem como determinar as principais lesões do sistema urinário associadas à ocorrência de uremia.…”

Anatomo-pathological and epidemiological analysis of urinary tract lesions in dogs

“…In dogs, diseases of the urinary tract are common (MAXIE & NEWMAN, 2007) and may be caused by disorders of varied etiology that induce structural and functional changes of the organs and which are diagnosed through its clinical aspects and histopathology (INKELMANN et al, 2012a). However, pathological studies of the urinary tract of small animals are rare and are mostly related to conditions of familial kidney disease or specific diseases (RHA et al, 2000).…”

Dystrophic mineralization in uremic dogs: an update

“…Although there are several studies addressing necroscopic and histopathologic lesions in dogs with chronic kidney disease (CKD) (Cheville 1979, Dantas & Kommers 1997, Peters et al 2005, Inkelmann et al 2012, Silveira et al 2015 in the literature, they do not correlate these lesions with serum calcium, phosphorus and PTH levels, which could better support discussion on the pathogenesis of pathological mineralization in the soft tissue of dogs with uremic syndrome. Thus, the objective of this study was to elucidate or provide subsidies to establish the type of pathological mineralization that occurs in uremic dogs.…”