Anatomo-pathological and epidemiological analysis of urinary tract lesions in dogs

Sapin, Carolina da Fonseca; Silva-Mariano, Luísa Cerqueira; Bassi, Jordana Nunes; Grecco, Fabiane Borelli

doi:10.1590/0103-8478cr20151235

Cited by 7 publications

(8 citation statements)

References 9 publications

(14 reference statements)

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“…According to many animal/ human cases, the infection can be explained by indiscriminate eating habits of these animals (Kommers et al, 1999) that occurred by eating infected worms or paratenic hosts as fish, crayfish or frogs in which the larvae become encapsulated in the tissue. As well as it can result from direct contact with contaminated water (Sapin et al, 2016). This agreement with Carolina et al (2016) who discussed that probability of infection through drinking water infested with infected annelid intermediate host.…”

Section: Discussionsupporting

confidence: 83%

“…Secondly, this structure was associated with severe histopathological lesions in the kidney (Acquired polycystic kidney and chronic sclerosing glomerular nephritis) which often lead to uremia and death of the affected host. As well as presence of a fibrous thick wall cyst which is filled with ring-like structure that is the characteristic pathological criteria of the D. renale eggs which harmonized with Sapin et al (2016). Finally, there are not record or documented larva migrate nematodes associated with polycystic kidney appearance except Ascaris which totally showed different in pathological criteria.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Case Study: Dioctophyma renale Infection in Mice, Incidental Finding During Experimental Studies

Abdel-Hakeem

Abdel-Samiee

2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Case Study: Dioctophyma renale Infection in Mice, Incidental Finding During Experimental Studies

Abdel-Hakeem

Abdel-Samiee

2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“…A metaplasia óssea observada no presente estudo é descrita na parede dos rins de furões e visions ) e raramente em cães (Sapin et al 2016(Sapin et al , 2017, sendo que esta ocorre pela constante agressão da parede renal pelas enzimas proteolíticas e lipolíticas produzidas pelas glândulas esofágicas de D. renale.…”

Section: Discussionunclassified

Dioctofimatose renal bilateral e disseminada em cão

et al. 2017

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RESUMO.-Este trabalho descreve dioctofimatose renal bilateral e disseminada em canino no município de Pelotas, na região sul do Rio Grande do Sul. Uma cadela sem raça definida, de dois anos de idade e semi-domiciliada foi submetida a exame ultrassonográfico observando-se alterações sugestivas de parasitismo por Dioctophyme renale. O animal veio à morte antes de ser conduzido para nefrectomia e remoção dos parasitas. Foi encaminhado para necropsia no Laboratório Regional de Diagnóstico da Faculdade de Veterinária da UFPel. Macroscopicamente, ao corte do rim direito observou-se atrofia do parênquima com formações císticas e exsudato serosanguinolento com quatro exemplares fême-as de D. renale. A cápsula renal media 0,4cm de espessura, e apresentava placas multifocais esbranquiçadas, irregulares e de consistência dura, medindo até 2cm de diâmetro. Na pelve do rim esquerdo, havia um parasita macho de 22cm. A bexiga possuía conteúdo escurecido e pastoso. Ainda, livre na cavidade abdominal, próximo ao rim direito havia outro parasita macho de 30cm. No fígado havia região cicatricial no lobo em contato com o parasita. No tórax identificou-se livre na cavidade e formando impressão sob a gordura pericárdica, um parasita macho de D. renale, medindo 20cm. Histologicamente, além de lesões características da enfermidade, observou-se metaplasia óssea na capsula renal direita. TERMOS DE INDEXAÇÃO:Dioctophyme renale, dioctofimatose, rim, metaplasia óssea, renal bilateral, canino.

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“…As lesões macroscópicas esbranquiçadas, irregulares e firmes observadas na cápsula renal, foram classificadas histologicamente por vezes como calcificação distrófica ou metaplasia óssea. A metaplasia óssea tem sido descrita em furões e visions [6] e raramente em cães [13,14], a qual se desenvolve provavelmente pela ação constante das enzimas liberadas pelas glândulas esofágicas do parasito, caracterizando a cronicidade do processo e a consequente tentativa do tecido conjuntivo em adaptar-se. Tal condição parece também estar relacionada à hiperplasia do epitélio de transição da pelve do rim parasitado [5,11].…”

Section: Discussionunclassified

Anatomopathologic Study of Kidneys parasitized by Dioctophyme renale in Dogs

Sapin

Silva-Mariano

Piovesan

et al. 2017

Acta Scientiae. Vet.

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Background: Dioctophymiasis is a disease caused by the nematode Dioctophyme renale and is a relatively common condition in dogs. The parasite affects the kidney, especially the right, enters the kidney capsule and causes destruction and atrophy of the parenchyma. The lesion severity depends on the amount of parasites affecting the kidney, the duration of the infection, number of kidneys involved and concurrent occurrence of kidney disease. The disease’s clinical presentation may be asymptomatic or with nonspecific clinical signs. The diagnosis is based on ultrasound examination and the detection of eggs in urine, however, diagnosis is often reached only through necropsy or histopathology. This study aimed to analyze the dog kidney anatomical and pathological changes when parasitized by Dioctophyme renale.Materials, Methods & Results: The kidneys of 21 dogs diagnosed with dioctophymiasis were nephrectomized, analyzed by ultrasound and forwarded to macro and microscopic analysis. Macroscopically, the kidney size was measured as well as its renal capsule thicknes. The presences of dilatation of the renal pelvis and ureter, as well as changes of the capsule, were also observed. These fragments were collected and submitted for routine analysis and stained with hematoxylin and eosin. Histopathological examination was performed blindly by three evaluators. The intensity of fibrosis was evaluated by the presence or absence of infiltration, the absence or presence of parasite eggs and when present whether there was inflammatory tissue response, among other changes. All received organs were right kidneys and showed clear atrophy or absence of the parenchyma. The kidney size ranged from 3,8x2,5x1,3 cm to 8,4x8,2x4,0 cm and the capsule thickness between 0.1 and 3.6cm. In renal capsule were observed whitish, irregular and firm plates (10 out of 21 cases) and papilliform projections (4 out of 21). In two specimens were identified cases of hydroureter and hydronephrosis. Microscopically, all specimens had some degree of fibrosis which replaced the renal parenchyma, six classified as mild, ten were moderate and five intense. In 13 cases there was intense deposition of parasite eggs and 18 cases showed inflammatory infiltrate of which one was pyogranulomatous and one granulomatous. Papilliform projections were observed in six out of 21 cases (composed of connective tissue proliferation and neovascularization), there was also hyperplasia of the pelvis transition epithelial (6 out of 21) and osseous metaplasia of the renal capsule (4 out of 21). The vessels walls were hypertrophic in nine out of 21 cases.Discussion: The diagnosis of dioctophymiasis was performed by ultrasonography. All 21 kidneys analyzed were rights; this is related to the parasite penetration in the duodenal wall, which tends to migrate by anatomic proximity to the right kidneys. Dioctophyme renale feeds through digestion and ingestion of the renal parenchyma by the action of parasite’s oesophageal enzymes causing progressive destruction of the cortical and medullar layers and consequently the proliferation of fibrous tissue. In this study, different intensities of fibrosis were observed. Bone metaplasia characterizes the chronicity of the process and the connective tissue’s attempt to adapt. Animals affected by dioctophymiasis often develop chronic renal failure. Chronic renal failure is characterized by continuous and irreversible morphologic changes in the renal parenchyma with loss of nephron components and the formation of a vicious cycle of replacement by fibrous connective tissue. The hypertrophy of vascular epithelium observed in six cases of this study may be associated with fibrous connective tissue proliferation stimulus. The injuries described here may be related to the parasitosis late diagnosis.

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Anatomo-pathological and epidemiological analysis of urinary tract lesions in dogs

Abstract: In dogs, diseases of the urinary tract are common and can be caused by disorders of varied etiology. The objective of this study was to classify qualitatively and quantitatively

Cited by 7 publications

References 9 publications

Case Study: Dioctophyma renale Infection in Mice, Incidental Finding During Experimental Studies

Case Study: Dioctophyma renale Infection in Mice, Incidental Finding During Experimental Studies

Dioctofimatose renal bilateral e disseminada em cão

Anatomopathologic Study of Kidneys parasitized by Dioctophyme renale in Dogs

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