Aspectos clínico-patológicos e imuno-histoquímicos de equídeos infectados pelo vírus da raiva

Pedroso, Pedro Miguel Ocampos; Colodel, Edson M.; Gomes, Danilo Carloto; Varaschin, Mary Suzan; Júnior, Pedro Soares Bezerra; Barbosa, José Diomedes; Tokarnia, Carlos Hubinger; Driemeier, David

doi:10.1590/s0100-736x2010001100002

Cited by 7 publications

(15 citation statements)

References 12 publications

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“…46 IHC, in the present study, revealed the presence of viral antigen in all 33 rabies cases; this is in agreement with another work 40 in which the viral antigen was detected in all (39) of the cases analyzed. Additionally, 22 of the cases analyzed in our study (66.6%) were positive for rabies as detected by DFAT; this frequency is similar to that found in another study 31 in which 55% of the samples from horses diagnosed with rabies were positive as detected by DFAT. These data show that complete agreement between tests may not happen for all samples.…”

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Characterization of spinal cord lesions in cattle and horses with rabies

et al. 2016

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Twenty-six cattle and 7 horses were diagnosed with rabies. Samples of brain and spinal cord were processed for hematoxylin and eosin staining and immunohistochemistry (IHC). In addition, refrigerated fragments of brain and spinal cord were tested by direct fluorescent antibody test and intracerebral inoculation in mice. Statistical analyses and Fisher exact test were performed by commercial software. Histologic lesions were observed in the spinal cord in all of the cattle and horses. Inflammatory lesions in horses were moderate at the thoracic, lumbar, and sacral levels, and marked at the lumbar enlargement level. Gitter cells were present in large numbers in the lumbar enlargement region. IHC staining intensity ranged from moderate to strong. Inflammatory lesions in cattle were moderate in all spinal cord sections, and gitter cells were present in small numbers. IHC staining intensity was strong in all spinal cord sections. Only 2 horses exhibited lesions in the brain, which were located mainly in the obex and cerebellum; different from that observed in cattle, which had lesions in 25 cases. Fisher exact test showed that the odds of detecting lesions caused by rabies in horses are 3.5 times higher when spinal cord sections are analyzed, as compared to analysis of brain samples alone.

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“…9,16,42 Additionally, multifocal hemorrhagic areas were observed in the spinal cords of all horses, sometimes macroscopically, which corroborates findings of other authors. 13,31 The exact mechanism by which RABV causes neuronal lesions and ultimately death is unknown. One hypothesis is marked viral-induced downregulation of genes in the brain.…”

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Characterization of spinal cord lesions in cattle and horses with rabies

et al. 2016

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“…This is because in horses, in addition to the CNS samples required for collection in ruminants, sampling of cervical, thoracic and lumbar spinal cord segments is essential for the diagnosis of most neurological diseases, since lesions are often located in this region (Rech & Barros, 2015). If samples are not collected and stored correctly, laboratory diagnosis will not be successful, leading to inconclusive results (Pedroso et al 2010;Peixoto et al, 2000;Rech & Barros, 2015).…”

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confidence: 99%

Epidemiological surveillance of West Nile virus in the world and Brazil

Costa¹,

Bayeux²,

Silva

et al. 2020

Braz. J. Vet. Res. Anim. Sci.

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West Nile virus (WNV) is a neurovirulent mosquito-borne Flavivirus that is maintained in nature by a zoonotic transmissioncycle between avian hosts and ornithophilic mosquito vectors, mostly from the Culex genus. Until the 1990s, WNV wasconsidered to be an old-world arbovirus, but in 1999, WNV emerged in the United States (US) and spread rapidly, becoming amajor threat to public health. WNV adapted to the transmission cycle involving American mosquitoes and birds and reachedCentral and South America in subsequent years. In 2003, the National West Nile Fever Surveillance System was created in Brazilbased on serological screening of animals and sentinel vectors, as recommended by the Pan American Health Organization(PAHO) and the World Health Organization (WHO). Since 2008, serological evidence of WNV infection in Brazilian horseshas been reported, and the circulation of WNV has been monitored through the regular serological screening of sentinel horsesand reporting of encephalomyelitis cases. Horses are highly susceptible to WNV infection, and outbreaks of neurologicaldisease among horses often precede human cases. In this regard, equine surveillance has been essential in providing earlywarning to public and animal health authorities in several countries, including Brazil. This demonstrates the need for animaland public health intervention programs to allocate resources to make veterinarians aware of the role they can play in thehuman surveillance processes by monitoring horses. This review discusses the importance of equine surveillance and the gapthat veterinarians can fill on the front line in human surveillance, in Brazil and worldwide, in the context of “One Health”

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“…According to Pedroso et al (2010), the number of positive cases is great because samples are not sent to laboratory diagnosis and research about such a disease in this species is scarce (Lima et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

Barrosa¹,

Langoni

Victória³

et al. 2018

Braz. J. Vet. Med.

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Rabies is a zoonosis of extreme importance to public health. Specifically in herbivores it causes economic losses, considering its lethality. The diagnosis provides information to describe the epidemiology of the disease in the regional study. For this purpose, a survey of Central Nervous System (CNS) materials, received for diagnosis in the Center-West region of the State of São Paulo, by the Zoonosis Diagnostic Service (SDZ), Faculdade de Medicina Veterinária e Zootecnia (FMVZ)-UNESP-Botucatu-SP. In the period from 2001 to 2015, a total of 643 samples were analyzed, being 489 (76.05%) of the bovine species, with 68 (13.9%) positive samples and 154 (23.95%) of the equine species with 17 (11.3%) positive. For the analyzed bovine samples, sensitivity and specificity values of the fluorescent antibody test (FAT) were 88.24 and 99.52% respectively and for equines, 47.06 and 100.0%. The frequency of samples received by species, month, and year and the results of the diagnostic tests recommended by the World Health Organization (WHO), fluorescent antibody test (FAT) and the mouse inoculation test (MIT), were analysed.

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Aspectos clínico-patológicos e imuno-histoquímicos de equídeos infectados pelo vírus da raiva

Cited by 7 publications

References 12 publications

Characterization of spinal cord lesions in cattle and horses with rabies

Characterization of spinal cord lesions in cattle and horses with rabies

Epidemiological surveillance of West Nile virus in the world and Brazil

Results of laboratory diagnosis of rabies in herbivores (cattle and horses): a retrospective study

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