Enfermidades associadas à intoxicação por selênio em animais

Oliveira, Krishna Düro de; França, Ticiana N.; Nogueira, Vivian A.; Peixoto, Paulo Vargas

doi:10.1590/s0100-736x2007000400001

Cited by 10 publications

(8 citation statements)

References 34 publications

(96 reference statements)

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“…Pode ser encontrado em rochas, arenitos, carvão, solo, água de superfície e vegetação (Fan & Kizer 1990). Após a descoberta dos efeitos benéficos capazes de reduzir a peroxidação das membranas celulares, o Se passou a ser incluído em suplementos minerais, aumentando os riscos de intoxicação para os animais e o homem, uma vez que há uma pequena diferença entre as doses, terapêutica e tóxica (Oliveira et al 2007).…”

Section: Introductionunclassified

Intoxicação por selênio em suínos no Sul do Brasil

et al. 2014

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RESUMO.-São descritos dois surtos de intoxicação por selênio em suínos na região Sul do Brasil. Foram acometidos leitões em fase de creche, entre 27 e 22 dias, com mortalidade variando de 16% a 15,3% (Surto 1 e 2 respectivamente). Os suínos apresentaram poliomielomalacia simétrica focal e lesões de casco, que inicialmente eram caracterizadas por uma linha avermelhada na borda coronária que evoluía nos suínos sobreviventes para desprendimento do casco. Os sinais clínicos iniciaram após seis dias (Surto 1) e 30 horas (Surto 2) da introdução da ração com alto teor de selênio. O surgimento dos sinais foi abrupto, caracterizado por andar cambaleante, com evolução para paralisia dos membros pélvicos e posteriormente tetraparesia. Macroscopicamente observaram-se focos circulares amarelados com áre-as deprimidas mais escuras, restritas ao corno ventral da substância cinzenta em intumescências cervical e lombar. Microscopicamente essas áreas corresponderam à malacia da substância cinzenta, caracterizada por microcavitações, perda neuronal, cromatólise, neuronofagia, infiltrado de células Gitter, microgliose, astrócitos de Alzheimer tipo II e proliferação de células endoteliais evidenciadas na imunohistoquímica (IHQ) para fator de von Willebrand. Ainda, Two outbreaks of poisoning by selenium in swine in southern Brazil are described. Piglets were affected in the post-weaning period, between 27 and 22 days, with mortality rates ranging from 16% to 15.3% (Outbreak 1 and 2 respectively). The pigs had focal symmetrical poliomielomalacia and hoof lesions, which were initially characterized by a reddish line at the coronary band that evolved in surviving pigs to release of the hooves. Clinical signs were observed after six days (Outbreak 1) and 30h (Outbreak 2) after the introduction of feed with high selenium content. The appearance of the signs was abrupt, characterized by gait and progressing to paralysis of the hind limbs and later to tetraparesis. Macroscopically, in some animals there were yellow circular foci with darker areas restricted to the ventral horn of the gray matter in the cervical and lumbar intumescence. Microscopically, these areas correspond to gray matter malacia, characterized by microcavitation, neuronal loss, chromatolysis, neuronophagia, infiltrating Gitter cells, microgliosis, Alzheimer's type II astrocytes and proliferation of endothelial cells which were labeled by immunohistochemistry (IHC) as von Willebrand factor. Also in the second outbreak, two pigs showed diffuse vacuolation of the cytoplasm of neurons and in one pig gemistocytic astrocytes were observed. In IHC for GFAP astrocytosis and astrogliosis was observed. Besides those spinal changes in two pigs symmetrical polioencephalomalacia in the brainstem was found. In feed samples, 3.38ppm (Outbreak 1) and 154ppm (Outbreak 2) of Se/kg were detected, and in liver samples higher dosages than 3.34ppm (range from 3.34 to 10ppm) were found. In Outbreak 2, 44 days after the withdrawal of the diet, the euthanasia of six pigs was performed to monitor ...

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Section: Introductionunclassified

Intoxicação por selênio em suínos no Sul do Brasil

et al. 2014

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“…Forage plants are classified as passive accumulators due its ability to contain 10-30 mg kg −1 of Se in dry matter; however, high-quantity animal intake of Se through dry matter intake could induce intoxication [19]. Although the research with Urochloa brizantha grown in a weathered tropical soil containing 1.8-4.6 mg dm −3 Se resulted in high levels of Se uptake affecting biomass production, regardless of the soil type, plants showed high levels of Se in leaves [20].…”

Section: Selenium Fertilization In Tropical Weathered Soilsmentioning

confidence: 99%

Selenium Fertilization in Tropical Pastures

Faria¹,

Luz²,

Abdalla³

2020

Importance of Selenium in the Environment and Human Health

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Brazil is one of the largest meat producers. Meat along with other animal products have been responsible for its larger contribution as source of selenium (Se) for human. However, Se deficiency remains a concern because researches have indicated that this nutrient is found in low levels in Brazilian diet. Cattle in Brazil are fed basically from pasture, but there are strong evidences that soils contain low availability of Se; consequently plants and animals incorporate low Se levels. Pastures, Se fertilized, bring benefits to nutrition and health of animal consequently to humans already known in some countries. In contrast, Se fertilization on tropical weathered soils and tropical forages is little known. However, Se management as fertilizer in tropical environments requires researches involving field experiments, especially with animals, for establishing of safe and effective Se recommendations as fertilizer due to the Se toxicity potential and complexity in system of soil-plant-animal-human.

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“…Selenium fertilization in these areas could improve concentration of Se in the soil and consequently improving the metabolism and quality of plants (RIOS et al, 2010).There are complex paths associated with enrichment of Se by fertilization, which include the existence of different Se forms, difficulties to reach desirable levels in leaves or edible parts of plants (LI et al, 2008) and at the same time take care to avoid yield damages and/or toxicity (MARTINEZ et al, 2009). However, there are cereals and forages that are able to uptake high levels of Se and do not develop phytotoxicity (OLIVEIRA et al, 2007) that could result in animal intoxication, since requirement of Se by cattle in a dry matter base is between 0.1 to 0.3mg kg -1 (NRC, 2001).…”

Section: Introductionmentioning

confidence: 99%

Brachiaria enrichment with selenium-coated urea

et al. 2018

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Selenium (Se) fertilization in grazing to biofortification of animal products have been carried out in low Se soils. The objective of this study was to increase the Se content in the biomass of Brachiaria spp.with urea coated with Se. The experiment was performed in a typical Hapludox soil under greenhouse conditions. A completely randomized block design with four replicates in a factorial structure with two cuts and six Se doses (0, 10, 20, 40, 80, and 160gha-1) was used. The Brachiaria brizantha demonstrated the absence of changes in higher harmful doses without modifying the activity of glutathione peroxidase enzyme. We concluded that enrichment of Brachiaria brizantha with coated urea is obtained with 34.5gha-1of Se.

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Enfermidades associadas à intoxicação por selênio em animais

Cited by 10 publications

References 34 publications

Intoxicação por selênio em suínos no Sul do Brasil

Intoxicação por selênio em suínos no Sul do Brasil

Selenium Fertilization in Tropical Pastures

Brachiaria enrichment with selenium-coated urea

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