Repercussões maternas, reprodutivas e perinatais do tratamento com extrato aquoso de folhas de Bauhinia forficata (pata-de-vaca) na prenhez de ratas não-diabéticas e diabéticas

Volpato, Gustavo Tadeu

doi:10.1590/s0100-72032001000600012

Cited by 3 publications

(2 citation statements)

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“…The literature evidences that 10 to 20% of the newly born of control female rats (non-diabetic) present that type of smaller visceral malformation. This result seems not to be exclusive of the diabetes [ 52 - 54 ] and does not exist definition about the critical period of the pregnancy of female rats for the development of these structures. Therefore, the mild diabetes induced in the neonatal period and during pregnancy showed no teratogenic effect on fetuses.…”

Section: Discussionmentioning

confidence: 96%

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

Saito

Damasceno

Kempinas

et al. 2010

Diabetol Metab Syndr

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BackgroundExperimental models are necessary to elucidate diabetes pathophysiological mechanisms not yet understood in humans. Objective: To evaluate the repercussions of the mild diabetes, considering two methodologies, on the pregnancy of Wistar rats and on the development of their offspring.MethodsIn the 1st induction, female offspring were distributed into two experimental groups: Group streptozotocin (STZ, n = 67): received the β-cytotoxic agent (100 mg STZ/kg body weight - sc) on the 1st day of the life; and Non-diabetic Group (ND, n = 14): received the vehicle in a similar time period. In the adult life, the animals were mated. After a positive diagnosis of pregnancy (0), female rats from group STZ presenting with lower glycemia than 120 mg/dL received more 20 mg STZ/kg (ip) at day 7 of pregnancy (2nd induction). The female rats with glycemia higher than 120 mg/dL were discarded because they reproduced results already found in the literature. In the mornings of days 0, 7, 14 and 21 of the pregnancy glycemia was determined. At day 21 of pregnancy (at term), the female rats were anesthetized and killed for maternal reproductive performance and fetal development analysis. The data were analyzed using Student-Newman-Keuls, Chi-square and Zero-inflated Poisson (ZIP) Tests (p < 0.05).ResultsSTZ rats presented increased rates of pre (STZ = 22.0%; ND = 5.1%) and post-implantation losses (STZ = 26.1%; ND = 5.7%), reduced rates of fetuses with appropriate weight for gestational age (STZ = 66%; ND = 93%) and reduced degree of development (ossification sites).ConclusionMild diabetes led a negative impact on maternal reproductive performance and caused intrauterine growth restriction and impaired fetal development.

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Section: Discussionmentioning

confidence: 96%

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

Saito

Damasceno

Kempinas

et al. 2010

Diabetol Metab Syndr

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“…Essa solução teve efeito hipoglicemiante nos ratos machos e fêmeas do estudo (OLiveiRa et al, 2002). Volpato et al (2007) também avaliou o efeito do extrato aquoso de yacon em ratas diabéticas e não diabéticas, porém não obtiveram diferenças significativas relacionadas a glicemia, sugerindo utilizar doses maiores que 32,4mg/kg do extrato.…”

Section: A Batata Yaconunclassified

Aplicabilidade dos frutooligossacarídeos como alimento funcional

Rosa

Cruz

2022

NUTRIVISA

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O setor alimentício busca desenvolver alimentos que, além de características nutricionais adequadas, apresentem componentes que exercem funções biológicas capazes de prevenir doenças e promover a saúde, como os alimentos funcionais. Dentre esses alimentos, destacam-se os frutooligossacarídeos. Assim, este trabalho teve o objetivo de caracterizar os frutooligossacarídeos quanto às suas propriedades físico-quimicas, aplicação na indústria de alimentos, fontes naturais e função como prebiótico na saúde humana. Trata-se de um estudo descritivo, do tipo revisão bibliográfica, de abordagem qualitativa. Os resultados mostram a importância dos estudos que buscam assegurar as propriedades dos frutooligossacarídeos, evidenciando a sua importância como um componente promissor para a indústria alimentícia e para os indivíduos que buscam uma alimentação mais saudável, com diversas características funcionais.

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Riachin, a new cyanoglucoside from Bauhinia pentandra and its antioxidant activity

et al. 2013

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Repercussões maternas, reprodutivas e perinatais do tratamento com extrato aquoso de folhas de Bauhinia forficata (pata-de-vaca) na prenhez de ratas não-diabéticas e diabéticas

Cited by 3 publications

References 0 publications

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

Aplicabilidade dos frutooligossacarídeos como alimento funcional

Riachin, a new cyanoglucoside from Bauhinia pentandra and its antioxidant activity

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