Sirolimus influence on hepatectomy-induced liver regeneration in rats

Toderke, Edimar Leandro; Baretta, Giórgio Alfredo Pedroso; Filho, Ozimo Pereira Gama; Matias, Jorge Eduardo Fouto

doi:10.1590/s0100-69912014000300012

Cited by 6 publications

(5 citation statements)

References 27 publications

(26 reference statements)

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“…Research on liver regeneration and factors that can accelerate this process has a major relevance for the area of health 5 . Considering that when using adult rats, we can analyze the phenomenon of liver regeneration in the absence of growth stimuli of the organism, excluding the general and specific mechanisms that could be in effect inducing cell division activity in various tissues and organs 28 . This pioneering study, therefore deserves to be complemented with the intention of identifying the active principles present in Baccharis trimera, the mechanisms involved in the stimulation of hepatocyte proliferation, incorporate a minimum of two independent markers from hepatocyte proliferation.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Lima

Figueiredo²,

Santana³

et al. 2017

Acta Cir. Bras.

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Section: ■ Discussionmentioning

confidence: 99%

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Lima

Figueiredo²,

Santana³

et al. 2017

Acta Cir. Bras.

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“…In another study 20 , experts have used an immunosuppressant (sirolimus) as drug to induce regeneration. When immunohistochemistry slides with Ki-67 marker were rated, the authors obtained a significant value (p=0.04) comparing the control and experimental groups seven days after partial hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

Sobral

Daga

Rasera

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: Different lesions may affect the liver resulting in harmful stimuli. Some therapeutic procedures to treat those injuries depend on liver regeneration to increase functional capacity of this organ. Aim: Evaluate the effects of tranexamic acid on liver regeneration after partial hepatectomy in rats. Method: 40 rats (Rattus norvegicus albinus, Rodentia mammalia) of Wistar-UP lineage were randomly divided into two groups named control (CT) and tranexamic acid (ATX), with 20 rats in each. Both groups were subdivided, according to liver regeneration time of 32 h or seven days after the rats had been operated. The organ regeneration was evaluated through weight and histology, stained with HE and PCNA. Results: The average animal weight of ATX and CT 7 days groups before surgery were 411.2 g and 432.7 g, and 371.3 g and 392.9 g after the regeneration time, respectively. The average number of mitotic cells stained with HE for the ATX and CT 7 days groups were 33.7 and 32.6 mitosis, and 14.5 and 14.9 for the ATX and CT 32 h groups, respectively. When stained with proliferating cell nuclear antigen, the numbers of mitotic cells counted were 849.7 for the ATX 7 days, 301.8 for the CT 7 days groups, 814.2 for the ATX 32 hand 848.1 for the CT 32 h groups. Conclusion: Tranexamic acid was effective in liver regeneration, but in longer period after partial hepatectomy.

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“…However, after chemical, viral and traumatic injury, hepatocytes are able to undergo a proliferative response in order to restore the lost parenchyma 1 . Liver proliferation is a compensatory hyperplasia process, which is driven more by functional than anatomical need 2 .…”

Section: Introductionmentioning

confidence: 99%

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

Figueiredo

Santana²,

Nardelli

et al. 2016

Acta Cir. Bras.

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PURPOSE:To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS:Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS:The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION:Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.

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Sirolimus influence on hepatectomy-induced liver regeneration in rats

Abstract: there was no negative influence of sirolimus in liver regeneration and there was a positive partial effect at immunohistochemistry with Ki-67.

Cited by 6 publications

References 27 publications

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Tranexamic Acid Action on Liver Regeneration After Partial Hepatectomy: Experimental Model in Rats

The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy

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