Efeitos dos ácidos graxos sobre a regeneração hepática em ratos

Melo, José Ulisses de Souza; Santos, Jefferson Menezes Viana; Kimura, Osamu; Júnior, Manoel Messias Campos; Melo, Radamés Bezerra; Vasconcelos, Paulo Roberto Leitão de

doi:10.1590/s0100-69912010000500008

Cited by 17 publications

(7 citation statements)

References 42 publications

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“…Another study dealing with Ω3FAs supplementation, which did not use a regeneration model, reported that this compound did protect against oxidative stress induced DNA-damage in the liver [7]. However, there are contradicting studies reporting negative effects of long chain Ω3FAs on regenerating [26] and normal liver [27] with diverse results on oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

et al. 2017

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PurposeLipid peroxidation and consequent reactive oxygen species in the setting of oxidative stress have crucial roles in liver regeneration, which may adversely affect the regeneration itself and lead to liver failure. The aim of the current study is to investigate whether omega-3 fatty acid supplementation inhibits oxidative stress in an experimental model of liver regeneration.MethodsForty rats were allocated to four groups. Rats in group A received a sham operation. Rats in group B were subjected to right portal vein ligation (RPVL) and saline infusion. Rats in groups C and D were subjected to RPVL and total parenteral nutrition (TPN) with an all-in-one admixture containing a soybean oil based lipid emulsion. Rats in group D were additionally supplemented with omega-3 fatty acid infusion. Oxidative stresses in the blood and liver were measured by glutathione, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and nitric oxide.ResultsOmega-3 supplementation to the TPN solution significantly corrected alterations in the blood and tissue concentrations of oxidants and anti-oxidants during regeneration (P < 0.05).ConclusionOmega-3 fatty acid supplementation to the TPN solution revealed promising results in removal of oxidative stress that emerges during liver regeneration.

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Section: Discussionmentioning

confidence: 99%

Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

et al. 2017

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“…Concerning these previous reports and these results (which demonstrated the efficacy of DKT to the liver), we hypothesized that DKT may accelerate liver regeneration after hepatectomy. A 70% hepatectomy rat model was established according to the classical Higgins-Anderson procedure [13] , and the model was then gavaged with DKT every 12 h from 12 h before the laparotomy to 72 h after the laparotomy. The liver/body weight ratio and number of Ki67 positive cells were compared between the DKT group and control group.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models

Izumi

Takatsuki

Soyama

et al. 2015

Annals of Medicine &Amp; Surgery

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IntroductionTo clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound.MethodsNormal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system.ResultsThe PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC.DiscussionDKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract.ConclusionWe suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction.

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“…Furthermore, it is known that corn oil has significant levels of omega-6 and some studies suggest that diets rich in omega-6 provided improvement in liver regeneration 20 . Thus, we included this oil to evaluate if this substance shows improvement liver regeneration or if it is a standard of control substance to experiments with copaiba.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the measurement of alkaline phosphatase and ɤ GT (Table 2), no significant difference between groups was showed. Regarding total bilirubin and fractions (Table 3) injury attenuation by copaiba oil was not due to stimulation of liver regeneration 9,11,20 . This evidence suggest the hypothesis that Copaiba`s mechanism takes place reducing free radicals in tissue by herbal anti-inflammatory properties, previously described by Noguchi et al 15 , suggesting an actual hepato protective effect of this oil.…”

Section: Discussionmentioning

confidence: 99%

“…This is supported due to lipid diet induces a rising in free radicals synthesis, leading the organism to be prepared with antioxidant defenses, such as a preconditioning status 20 . However, lipids concentrations are similar in groups treated seven days before with both oils, although decreases in aminotransferases levels was not observed in groups treated prophylactically with corn oil.…”

Section: Discussionmentioning

confidence: 99%

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